Development and study of photodynamic and Ga loaded high efficient and dual-functional antimicrobial agents
2018/30/Q/NZ7/00281
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
Voivodeship: pomorskie
Principal investigator (from the host institution)
dr hab. Mariusz Stanisław Grinholc
Number of co-investigators in the project: 7
Call
SHENG 1 – announced on 2018-06-15
- Amount awarded
- 1 752 800 PLN
- Project start date
- 2019-10-02
- Project end date
- 2023-10-01
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (5)
-
Iron-blocking antibacterial therapy with cationic heme-mimetic gallium porphyrin photosensitizer for combating antibiotic resistance and enhancing photodynamic antibacterial activity
- Authors:
- Hao Zhang, Qingsi Li, Xiaoyu Qi, Yi Li, Hongyan Ma, Mariusz Grinholc, Joanna Nakonieczna, Bingran Yu, Xing Wang, Lei Zhang
- Academic press:
- Chemical Engineering Journal (year: 2023, volume: 451, pages: 138261), Publisher: Elsevier Science SA
- Status:
- Published
- DOI:
- 10.1016/j.cej.2022.138261 – link to the publication
-
Photoactivated Gallium Porphyrin Reduces Staphylococcus aureus Colonization on the Skin and Suppresses Its Ability to Produce Enterotoxin C and TSST-1
- Authors:
- Klaudia Szymczak, Grzegorz Szewczyk, Michał Rychłowski, Tadeusz Sarna, Lei Zhang, Mariusz Grinholc, Joanna Nakonieczna
- Academic press:
- ACS Molecular Pharmaceutics (year: 2023, volume: 20, pages: 5108-5124), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.molpharmaceut.3c00399 – link to the publication
-
Gallium Mesoporphyrin IX-Mediated Photodestruction: A Pharmacological Trojan Horse Strategy To Eliminate Multidrug- Resistant Staphylococcus aureus
- Authors:
- Klaudia Michalska, Michał Rychłowski, Martyna Krupińska, Grzegorz Szewczyk, Tadeusz Sarna, Joanna Nakonieczna
- Academic press:
- ACS Molecular Pharmaceutics (year: 2022, volume: 19, pages: 1434-1448), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/acs.molpharmaceut.1c00993 – link to the publication
-
Development of Antimicrobial Phototreatment Tolerance: Why the Methodology Matters
- Authors:
- Aleksandra Rapacka-Zdończyk, Agata Woźniak, Joanna Nakonieczna, Mariusz Grinholc
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 2224), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22042224 – link to the publication
-
Decrease of ESKAPE virulence with a cationic heme-mimetic gallium porphyrin photosensitizer: The Trojan horse strategy that could help address antimicrobial resistance
- Authors:
- Klaudia Szymczak, Agata Woźniak-Pawlikowska, Natalia Burzyńska, Magdalena Król, Lei Zhang, Joanna Nakonieczna, Mariusz Grinholc
- Academic press:
- Journal of Photochemistry and Photobiology B-Biology (year: 2024, volume: 256, pages: 112928), Publisher: Elsevier Science SA
- Status:
- Published
- DOI:
- 10.1016/j.jphotobiol.2024.112928 – link to the publication