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The impact of model biological membranes on the structure and oligomerization process of human cystatin C.

2018/30/M/ST4/00039

Keywords:

cystatin C biological membranes mimetics oligomerization transmmebrane transport bipohysical methods

Descriptors:

  • ST4_3:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Czaplewska 

Number of co-investigators in the project: 6

Call: HARMONIA 10 - announced on 2018-06-15

Amount awarded: 843 500 PLN

Project start date (Y-m-d): 2019-04-12

Project end date (Y-m-d): 2023-04-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. The Influence of the Mixed DPC:SDS Micelle on the Structure and Oligomerization Process of the Human Cystatin C
    Authors:
    Przemyslaw Jurczak, Emilia Sikorska, Paulina Czaplewska, Sylwia Rodziewicz-Motowidlo, Igor Zhukov and Aneta Szymanska
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 45679), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11010017 - link to the publication
  2. Phospholipid-functionalized gold electrode for cellular membrane interface studies - interactions between DMPC bilayer and human cystatin C
    Authors:
    Paweł Niedziałkowski, Przemysław Jurczak, Marta Orlikowska, Anna Wcisło, Jacek Ryl, Tadeusz Ossowski, Paulina Czaplewska
    Academic press:
    BBA - Biomembranes (rok: 2024, tom: 1866, strony: 184266), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2023.184266 - link to the publication
  3. Monomer-dimer equilibrium of human cystatin C during internalization into cancer cells
    Authors:
    Przemyslaw Jurczak, Nour Fayad, Magalie Benard, Paulina Czaplewska, Niko Hildebrandt
    Academic press:
    ChemBioChem (rok: 2024, tom: -, strony: -), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.202400226 - link to the publication
  4. DMPC Phospholipid Bilayer as a Potential Interface for Human Cystatin C Oligomerization: Analysis of Protein-Liposome Interactions Using NMR Spectroscopy
    Authors:
    Przemyslaw Jurczak, Kosma Szutkowski, Slawomir Lach, Stefan Jurga, Paulina Czaplewska,Aneta Szymanska and Igor Zhukov
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 45671), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11010013 - link to the publication
  5. Monitoring the interactions between POPG phospholipid bilayer and amyloid-forming protein human cystatin C. Does the bilayer influence the oligomeric state and structure of the protein?
    Authors:
    Przemyslaw Jurczak, Igor Zhukov, Marta Orlikowska, Paulina Czaplewska, Emilia Sikorska
    Academic press:
    BBA - Biomembranes (rok: 2024, tom: 1866, strony: 184285), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2024.184285 - link to the publication
  6. Monitoring the interactions between POPG phospholipid bilayer and amyloid-forming protein human cystatin C. Does the bilayer influence the oligomeric state and structure of the protein?
    Authors:
    Przemyslaw Jurczak, Igor Zhukov, Marta Orlikowska, Paulina Czaplewska, Emilia Sikorska
    Academic press:
    BBA - Biomembranes (rok: 2024, tom: 1866, strony: 184285), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2024.184285 - link to the publication

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