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Regulatory mechanism involved in riboflavin overproduction in the flavinogenic yeast Candida famata

2018/29/B/NZ1/01497

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_2: Biochemia
  • NZ1_9: Biotechnologia

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

Voivodeship: podkarpackie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Andriy Sybirnyy

Number of co-investigators in the project: 5

Call

OPUS 15 – announced on 2018-03-15

Amount awarded
975 600 PLN
Project start date
2019-02-13
Project end date
2022-02-12
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Autoklaw laboratoryjny o pojemności 80L. Cost: 120 000 PLN
  2. Spektrofluorymetr. Cost: 180 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. SEF1 and VMA1 Genes Regulate Riboflavin Biosynthesis in the Flavinogenic Yeast Candida Famata

    Authors:
    Andreieva Y, Lyzak O, Liu W, Kang Y, Dmytruk K, Sibirny A
    Academic press:
    Cytology and Genetics (year: 2020, volume: 54, pages: 379-385), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.3103/S0095452720050023 – link to the publication

  2. Effect of Gene SFU1 on Riboflavin Synthesis in Flavinogenic Yeast Candida famata

    Authors:
    Petrovska Y, Lyzak O, Dmytruk K, Sibirny A.
    Academic press:
    Cytology and Genetics (year: 2020, volume: 54, pages: 408–412), Publisher: Allerton Press, Inc.,
    Status:
    Published
    DOI:
    10.3103/S0095452720050060 – link to the publication

  3. Expression of yeast homolog of the mammal BCRP gene coding for riboflavin efflux protein activates vitamin B2 production in the flavinogenic yeast Candida famata

    Authors:
    Tsyrulnyk A, Ruchala J, Fayura L, Dmytruk K, Fedorovyvh D, Sybirny A
    Academic press:
    Yeast (year: 2020, volume: 37, pages: 467-473), Publisher: Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1002/yea.3470 – link to the publication

  4. Modulation of the Purine Pathway for Riboflavin Productionin Flavinogenic Recombinant Strain of the Yeast Candida famata

    Authors:
    Dmytruk KV, Ruchala J, Fedorovych DV, Ostapiv RD, Sibirny AA.
    Academic press:
    Biotechnology Journal (year: 2020, volume: 15, pages: 46029), Publisher: Wiley (John Wiley & Sons)
    Status:
    Published
    DOI:
    10.1002/biot.201900468 – link to the publication

  5. Cloning of Genes Sef1 and Tup1 Encoding Transcriptional Activator and Global Repressor in the Flavinogenic Yeast Meyerozyma (Candida, Pichia) guilliermondii

    Authors:
    Fedorovych D, Boretsky V, Pynyaha Y., Bohovych I, Boretskya Y, Sibirny A
    Academic press:
    Cytology and Genetics (year: 2020, volume: 54, pages: 413-419), Publisher: Allerton Press, Inc.,
    Status:
    Published
    DOI:
    10.3103/S0095452720050072 – link to the publication

  6. Development of new dominant selectable markers for the nonconventional yeasts Ogataea polymorpha and Candida famata

    Authors:
    Bratiichuk D, Kurylenko O, Vasylyshyn R, Zuo M, Kang Y, Dmytruk K, Sibirny A.
    Academic press:
    Yeast (year: 2020, volume: 37, pages: 505-513), Publisher: Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1002/yea.3467 – link to the publication

Book publications / chapters in book publications (2)

  1. Overexpression of Riboflavin Excretase Enhances Riboflavin Production in the Yeast Candida famata

    Authors:
    Tsyrulnyk AO, Fedorovych DV, Dmytruk KV, Sibirny AA
    Book:
    Methods in Molecular Biology (year: 2021, volume: 2280, pages: 31-42), Publisher: Springer, New York, NY
    Status:
    Published

  2. Recent Advances in Construction of the Efficient Producers of Riboflavin and Flavin Nucleotides (FMN, FAD) in the Yeast Candida famata

    Authors:
    Fedorovych DV, Dmytruk KV, Sibirny AA.
    Book:
    Methods in Molecular Biology (year: 2021, volume: 2280, pages: 15-30), Publisher: Springer, New York, NY
    Status:
    Published

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