Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Atomization of liquids for targeted drug delivery to the respiratory system - mechanisms of droplets formation, transport and deposition

2018/29/B/ST8/00273

Keywords:

atomization inhalation aerosol therapy nasal aerosols

Descriptors:

  • ST8_1:
  • ST8_3:

Panel:

ST8 - Production and processes engineering: modelling, product design, process design and control, construction methods and engineering, power units and systems

Host institution :

Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Robert Sosnowski 

Number of co-investigators in the project: 8

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 189 880 PLN

Project start date (Y-m-d): 2019-05-30

Project end date (Y-m-d): 2023-11-29

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (22)
  • Articles in post-conference publications (21)
  • Book publications / chapters in book publications (14)
  1. Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model
    Authors:
    Sosnowski T.R., Rapiejko P., Sova J., Dobrowolska K.
    Academic press:
    International Journal of Pharmaceutics (rok: 2020, tom: 574, strony: 118911), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2019.118911 - link to the publication
  2. Wybrane zagadnienia fizykochemii koloidów w procesach inhalacyjnego dostarczania leków do płuc
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Academic press:
    Wiadomości Chemiczne (rok: 2021, tom: 75 (9-10), strony: 1375-1393), Wydawca: PTChem
    Status:
    Published
    DOI:
    10.12 - link to the publication
  3. Use of process intensification concepts for targeted delivery of inhaled aerosolized medicines
    Authors:
    Sosnowski Tomasz R., Florkiewicz Emil, Sosnowski Krzysztof
    Academic press:
    Chemical Engineering and Processing - Process Intensification (rok: 2024, tom: 203, strony: 109902), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cep.2024.109902 - link to the publication
  4. Influence of physicochemical properties of budesonide micro‐suspensions on their expected lung delivery using a vibrating mesh nebulizer
    Authors:
    Dobrowolska K., Emeryk A., Janeczek K., Krzosa R., Pirożyński M., Sosnowski, T.R.
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 752), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15030752 - link to the publication
  5. Evolution of droplet size distribution in selected nebulizers
    Authors:
    Dobrowolska K., Sosnowski T.R.
    Academic press:
    Physicochemical Problems of Mineral Processsing (rok: 2020, tom: 56, strony: 32-40), Wydawca: Wrocław University of Technology
    Status:
    Published
    DOI:
    10.37190/ppmp/126312 - link to the publication
  6. Mass and volume balances of nebulization processes for the determination of the expected dose of liquid medicines delivered by inhalation
    Authors:
    Sosnowski T.R., Janeczek K., Grzywna K., Emeryk A.
    Academic press:
    Chemical and Process Engineering (rok: 2021, tom: 47(3), strony: 253-261), Wydawca: PAN
    Status:
    Published
    DOI:
    10.24425/cpe.2021.138929 - link to the publication
  7. Wybrane zagadnienia fizykochemii koloidów w procesach inhalacyjnego dostarczania leków do płuc
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Academic press:
    Wiadomości Chemiczne (rok: 2021, tom: 75 (9-10), strony: 1375-1393), Wydawca: PTChem
    Status:
    Published
    DOI:
    10.12 - link to the publication
  8. Use of process intensification concepts for targeted delivery of inhaled aerosolized medicines
    Authors:
    Sosnowski Tomasz R., Florkiewicz Emil, Sosnowski Krzysztof
    Academic press:
    Chemical Engineering and Processing - Process Intensification (rok: 2024, tom: 203, strony: 109902), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cep.2024.109902 - link to the publication
  9. Aerosols and human health - a multiscale problem
    Authors:
    Sosnowski, T.R.
    Academic press:
    Chemical Engineering Science (rok: 2023, tom: 268, strony: 118407), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ces.2022.118407 - link to the publication
  10. Aerodynamically driven translocation of non-Newtonian fluids: the relevance for intranasal drug delivery
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Academic press:
    Chemical Engineering Transactions (rok: 2021, tom: 86, strony: 1207-1212), Wydawca: Italian Society of Chemical Engineering
    Status:
    Published
    DOI:
    10.3303/CET2186202 - link to the publication
  11. Evaluation and mitigation of carbon footprint of medical inhalers
    Authors:
    Sosnowski T.R., Wyleziński D., Emeryk A.
    Academic press:
    Chemical Engineering Transactions (rok: 2023, tom: 105, strony: 349-354), Wydawca: Italian Society of Chemical Engineering
    Status:
    Published
    DOI:
    10.3303/CET23105059 - link to the publication
  12. Dynamics of aerosol generation and flow during inhalation for improved in vitro-in vivo correlation (IVIVC) of pulmonary medicines
    Authors:
    Dorosz A., Moskal A., Sosnowski T.R.
    Academic press:
    Chemical and Process Engineering: New Frontiers (rok: 2023, tom: 44, strony: e39), Wydawca: PAN
    Status:
    Published
    DOI:
    10.24425/cpe.2023.147398 - link to the publication
  13. A particle technology approach toward designing dry-powder inhaler formulations for personalized medicine in respiratory diseases
    Authors:
    Kadota K.; Sosnowski T.R., Tobita S., Tachibana I., Tse J., Uchiyama K., Tozuka Y.
    Academic press:
    Advanced Powder Technology (rok: 2020, tom: 31, strony: 219–226), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.013 - link to the publication
  14. Mass and volume balances of nebulization processes for the determination of the expected dose of liquid medicines delivered by inhalation
    Authors:
    Sosnowski T.R., Janeczek K., Grzywna K., Emeryk A.
    Academic press:
    Chemical and Process Engineering (rok: 2021, tom: 47(3), strony: 253-261), Wydawca: PAN
    Status:
    Published
    DOI:
    10.24425/cpe.2021.138929 - link to the publication
  15. A particle technology approach toward designing dry-powder inhaler formulations for personalized medicine in respiratory diseases
    Authors:
    Kadota K.; Sosnowski T.R., Tobita S., Tachibana I., Tse J., Uchiyama K., Tozuka Y.
    Academic press:
    Advanced Powder Technology (rok: 2020, tom: 31, strony: 219–226), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.013 - link to the publication
  16. Aerodynamically driven translocation of non-Newtonian fluids: the relevance for intranasal drug delivery
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Academic press:
    Chemical Engineering Transactions (rok: 2021, tom: 86, strony: 1207-1212), Wydawca: Italian Society of Chemical Engineering
    Status:
    Published
    DOI:
    10.3303/CET2186202 - link to the publication
  17. Towards more precise targeting of inhaled aerosols to different areas of the respiratory system
    Authors:
    Sosnowski Tomasz R.
    Academic press:
    Pharmaceutics (rok: 2024, tom: 16(1), strony: 97), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics16010097 - link to the publication
  18. Critical Assessment of the Quantitative Criteria Used in the Comparison of Nebulizers
    Authors:
    Sosnowski Tomasz R.
    Academic press:
    EC PULMONOLOGY AND RESPIRATORY MEDICINE (rok: 2019, tom: 8,9, strony: 656-662), Wydawca: ECronicon
    Status:
    Published
  19. Evaluation and mitigation of carbon footprint of medical inhalers
    Authors:
    Sosnowski T.R., Wyleziński D., Emeryk A.
    Academic press:
    Chemical Engineering Transactions (rok: 2023, tom: 105, strony: 349-354), Wydawca: Italian Society of Chemical Engineering
    Status:
    Published
    DOI:
    10.3303/CET23105059 - link to the publication
  20. In silico evaluation of particle transport and deposition in the airways of individual patients with chronic obstructive pulmonary disease
    Authors:
    Kadota K., Matsumoto K., Uchiyama H., Tobita S., Maeda M., Maki M., Kinehara Y., Tachibana I., Sosnowski T.R., Tozuka Y.
    Academic press:
    Eur. J. Pharm. Biopharm. (rok: 2022, tom: 174, strony: 45949), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2022.03.010 - link to the publication
  21. Evolution of droplet size distribution in selected nebulizers
    Authors:
    Dobrowolska K., Sosnowski T.R.
    Academic press:
    Physicochemical Problems of Mineral Processsing (rok: 2020, tom: 56, strony: 32-40), Wydawca: Wrocław University of Technology
    Status:
    Published
    DOI:
    10.37190/ppmp/126312 - link to the publication
  22. Dynamics of aerosol generation and flow during inhalation for improved in vitro-in vivo correlation (IVIVC) of pulmonary medicines
    Authors:
    Dorosz A., Moskal A., Sosnowski T.R.
    Academic press:
    Chemical and Process Engineering: New Frontiers (rok: 2023, tom: 44, strony: e39), Wydawca: PAN
    Status:
    Published
    DOI:
    10.24425/cpe.2023.147398 - link to the publication
  1. Intensification of mass transfer of therapeutic aerosols and vaccines in the nasal cavity.
    Authors:
    Sosnowski T.R., Florkiewicz E.
    Conference:
    24th Polish Conference of Chemical and Process Engineering (rok: 2023, ), Wydawca: ZUT
    Data:
    konferencja 13-16.06.2023
    Status:
    Published
  2. Product design and engineering for pulmonary drug delivery
    Authors:
    Sosnowski T.R.
    Conference:
    European Congress of Chemical Engineering ECCE 13 and European Congress of Applied Biotechnology ECAB 6 (virtual event) (rok: 2021, ), Wydawca: Dechema
    Data:
    konferencja 20-23.09.2021
    Status:
    Published
  3. Physical factors determining the effectiveness of aerosol drug delivery to the nasal cavity
    Authors:
    Sosnowski T.R., Pawełkiewicz G.
    Conference:
    ECCE & ECAB: 14th European Congress of Chemical Engineering and 7th Congress of Applied Biotechnology (rok: 2023, ), Wydawca: Dechema
    Data:
    konferencja 17-21.09.2023
    Status:
    Published
  4. Zastosowanie inżynierii układów dyspersyjnych do analizy zagadnień inhalacyjnego podawania leków przy wykorzystaniu nebulizatorów
    Authors:
    Sosnowski T.R.
    Conference:
    X Kongres Technologii Chemicznej (rok: 2022, ), Wydawca: OWPWr
    Data:
    konferencja 11-14.05.2022
    Status:
    Published
  5. Chemical engineering as applied to medicine: the new challenges
    Authors:
    Sosnowski, T.R.
    Conference:
    4th International Scientific Conference Chemical Engineering and Technology" (rok: 2023, ), Wydawca: Lviv Polytechnic National University, Ukraine
    Data:
    konferencja 26-29.06.2023
    Status:
    Published
  6. Dynamics of aerosol generation and flow during inhalation for improved In Vitro-In Vivo Correlation (IVIVC) of pulmonary medicines.
    Authors:
    Dorosz A., Moskal A., Sosnowski T.R.
    Conference:
    24th Polish Conference of Chemical and Process Engineering (rok: 2023, ), Wydawca: ZUT
    Data:
    konferencja 13-16.06.2023
    Status:
    Published
  7. Understanding the dynamics of aerosols generated in medical nebulizers for better drug targeting in inhalation therapies
    Authors:
    Sosnowski T.R., Dobrowolska K., Moskal A.
    Conference:
    ECCE & ECAB: 14th European Congress of Chemical Engineering and 7th Congress of Applied Biotechnology (rok: 2023, ), Wydawca: Dechema
    Data:
    konferencja 17-21.09.2023
    Status:
    Published
  8. Chemical engineering as applied to medicine: the new challenges
    Authors:
    Sosnowski, T.R.
    Conference:
    4th International Scientific Conference Chemical Engineering and Technology" (rok: 2023, ), Wydawca: Lviv Polytechnic National University, Ukraine
    Data:
    konferencja 26-29.06.2023
    Status:
    Published
  9. Process intensification in medical applications – use of vibroaerosols for enhanced drug delivery into the paranasal sinuses
    Authors:
    Florkiewicz E., Taff J., Taff M. Sosnowski T.R.
    Conference:
    8th European Conference of Process Intensification (rok: 2023, ), Wydawca: Politechnika Warszawska
    Data:
    konferencja 31.05-2.06.2023
    Status:
    Published
  10. Zastosowanie inżynierii układów dyspersyjnych do analizy zagadnień inhalacyjnego podawania leków przy wykorzystaniu nebulizatorów
    Authors:
    Sosnowski T.R.
    Conference:
    X Kongres Technologii Chemicznej (rok: 2022, ), Wydawca: OWPWr
    Data:
    konferencja 11-14.05.2022
    Status:
    Published
  11. Process engineering-driven concepts for increasing the therapeutic efficacy of drugs delivered by nebulizers.
    Authors:
    Odziomek M., Dobrowolska K., Sosnowski T.R.
    Conference:
    24th Polish Conference of Chemical and Process Engineering (rok: 2023, ), Wydawca: ZUT
    Data:
    konferencja 13-16.06.2023
    Status:
    Published
  12. Understanding the dynamics of aerosols generated in medical nebulizers for better drug targeting in inhalation therapies
    Authors:
    Sosnowski T.R., Dobrowolska K., Moskal A.
    Conference:
    ECCE & ECAB: 14th European Congress of Chemical Engineering and 7th Congress of Applied Biotechnology (rok: 2023, ), Wydawca: Dechema
    Data:
    konferencja 17-21.09.2023
    Status:
    Published
  13. Liquid atomization process in medical applications
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Conference:
    Chemical Technology and Engineering 2021, Lviv, Ukraine (rok: 2021, ), Wydawca: Lviv Polytechnic National University
    Data:
    konferencja 21-24.06.2021
    Status:
    Published
  14. Dynamics of aerosol generation and flow during inhalation for improved In Vitro-In Vivo Correlation (IVIVC) of pulmonary medicines.
    Authors:
    Dorosz A., Moskal A., Sosnowski T.R.
    Conference:
    24th Polish Conference of Chemical and Process Engineering (rok: 2023, ), Wydawca: ZUT
    Data:
    konferencja 13-16.06.2023
    Status:
    Published
  15. Effect of liquid properties and aerosol dilution conditions on the final droplet size of aerosol delivered from nebulizers
    Authors:
    Dobrowolska K., Matyśkiewicz M., Sosnowski T.R.
    Conference:
    9th European Conference of Young Engineers (EYEC 2021) (rok: 2021, ), Wydawca: Warsaw University of Technology
    Data:
    konferencja 19-21.04.2021
    Status:
    Published
  16. Liquid atomization process in medical applications
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Conference:
    Chemical Technology and Engineering 2021, Lviv, Ukraine (rok: 2021, ), Wydawca: Lviv Polytechnic National University
    Data:
    konferencja 21-24.06.2021
    Status:
    Published
  17. Surfactants in aerosol drug delivery
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Conference:
    23rd Symposium on Surfactants in Solution" - SIS 2022 (rok: 2022, ), Wydawca: UMCS
    Data:
    konferencja 11-15.09.2022
    Status:
    Published
  18. Process intensification in medical applications – use of vibroaerosols for enhanced drug delivery into the paranasal sinuses
    Authors:
    Florkiewicz E., Taff J., Taff M. Sosnowski T.R.
    Conference:
    8th European Conference of Process Intensification (rok: 2023, ), Wydawca: Politechnika Warszawska
    Data:
    konferencja 31.05-2.06.2023
    Status:
    Published
  19. Process engineering-driven concepts for increasing the therapeutic efficacy of drugs delivered by nebulizers.
    Authors:
    Odziomek M., Dobrowolska K., Sosnowski T.R.
    Conference:
    24th Polish Conference of Chemical and Process Engineering (rok: 2023, ), Wydawca: ZUT
    Data:
    konferencja 13-16.06.2023
    Status:
    Published
  20. Surfactants in aerosol drug delivery
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Conference:
    23rd Symposium on Surfactants in Solution" - SIS 2022 (rok: 2022, ), Wydawca: UMCS
    Data:
    konferencja 11-15.09.2022
    Status:
    Published
  21. Effect of liquid properties and aerosol dilution conditions on the final droplet size of aerosol delivered from nebulizers
    Authors:
    Dobrowolska K., Matyśkiewicz M., Sosnowski T.R.
    Conference:
    9th European Conference of Young Engineers (EYEC 2021) (rok: 2021, ), Wydawca: Warsaw University of Technology
    Data:
    konferencja 19-21.04.2021
    Status:
    Published
  1. Experimental Analysis of the Deposition of Aerosol Droplets in the Upper Airways of Human
    Authors:
    Sosnowski Tomasz R.
    Book:
    Practical Aspects of Chemical Engineering (M.Ochowiak et al., Eds.) (rok: 2020, tom: 1, strony: 423–429), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
  2. Wpływ wybranych parametrów procesu nebulizacji na skuteczność celowanego dostarczania leków inhalacyjnych do płuc
    Authors:
    Sosnowski T.R., Marczyk K., Dobrowolska L., Moskal A.
    Book:
    Przepływy wielofazowe i operacje mechaniczne inżynierii procesowej (rok: 2022, tom: 1, strony: 101-106), Wydawca: Wydawnictwo Politechniki Gdańskiej
    Status:
    Published
  3. Nebulization in the subterranean conditions: the influence of ambient conditions on the generation of aerosols for inhalation
    Authors:
    Sosnowski Tomasz R., Koprowski Marek
    Book:
    Chemical and Process Engineering for Environment and Health. Current status in 2024 (rok: 2024, tom: 1, strony: 136-143), Wydawca: Wydawnictwo Naukowe Łukasiewicz - Instytut Technologii Eksploatacji
    Status:
    Published
  4. Particles and lungs – where chemical engineering meets medicine
    Authors:
    Sosnowski T.R.
    Book:
    Proceedings of the 2nd International Scientific Conference "Chemical Technology and Engineering" (rok: 2019, tom: 1, strony: 30-35), Wydawca: Lviv Polytechnic National University
    Status:
    Published
  5. Inhalation as a means of systemic drug delivery
    Authors:
    Sosnowski T.R.
    Book:
    Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications (rok: 2020, tom: 1, strony: 327-344), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
  6. Particles and lungs – where chemical engineering meets medicine
    Authors:
    Sosnowski T.R.
    Book:
    Proceedings of the 2nd International Scientific Conference "Chemical Technology and Engineering" (rok: 2019, tom: 1, strony: 30-35), Wydawca: Lviv Polytechnic National University
    Status:
    Published
  7. Czy można mieszać leki do nebulizacji i zamieniać nebulizatory.
    Authors:
    Pirożyński M, Sosnowski T.R.
    Book:
    Czy można mieszać leki do nebulizacji i zamieniać nebulizatory. Wyd. II uzupełnione. (rok: 2023, tom: 1, strony: 45668), Wydawca: Wydawnictwo Medycyna Praktyczna,
    Status:
    Published
  8. Nebulization in the subterranean conditions: the influence of ambient conditions on the generation of aerosols for inhalation
    Authors:
    Sosnowski Tomasz R., Koprowski Marek
    Book:
    Chemical and Process Engineering for Environment and Health. Current status in 2024 (rok: 2024, tom: 1, strony: 136-143), Wydawca: Wydawnictwo Naukowe Łukasiewicz - Instytut Technologii Eksploatacji
    Status:
    Published
  9. Two-dimensional LDA analysis of droplet velocity in aerosol clouds emitted from medical nebulizers
    Authors:
    Dobrowolska K., Antonowicz A., Sosnowski T.R.
    Book:
    Chemical and Process Engineering for the Environment and Health (rok: 2020, tom: 1, strony: 158-165), Wydawca: Sieć Badawcza Łukasiewicz - Instytut Technologii Eksploatacji, Wydawnictwo Naukowe
    Status:
    Published
  10. In vitro interactions of nebulized budesonide inhalation suspension with lung surfactant: the importance of drug formulation
    Authors:
    Sosnowski T.R., Dobrowolska K.
    Book:
    Respiratory Drug Delivery 2020 (rok: 2020, tom: 1, strony: 737-742), Wydawca: Virginia Commonwealth University
    Status:
    Published
  11. Two-dimensional LDA analysis of droplet velocity in aerosol clouds emitted from medical nebulizers
    Authors:
    Dobrowolska K., Antonowicz A., Sosnowski T.R.
    Book:
    Chemical and Process Engineering for the Environment and Health (rok: 2020, tom: 1, strony: 158-165), Wydawca: Sieć Badawcza Łukasiewicz - Instytut Technologii Eksploatacji, Wydawnictwo Naukowe
    Status:
    Published
  12. Wpływ wybranych parametrów procesu nebulizacji na skuteczność celowanego dostarczania leków inhalacyjnych do płuc
    Authors:
    Sosnowski T.R., Marczyk K., Dobrowolska L., Moskal A.
    Book:
    Przepływy wielofazowe i operacje mechaniczne inżynierii procesowej (rok: 2022, tom: 1, strony: 101-106), Wydawca: Wydawnictwo Politechniki Gdańskiej
    Status:
    Published
  13. Vibrating mesh nebulizers with a valved inhalation chamber for increased drug delivery to the lower airways
    Authors:
    Sosnowski T.R., Vilkotsky A.I., Emeryk A.
    Book:
    Respiratory Drug Delivery 2022 (rok: 2022, tom: 1, strony: 551-554), Wydawca: RDD Online
    Status:
    Published
  14. Vibrating mesh nebulizers with a valved inhalation chamber for increased drug delivery to the lower airways
    Authors:
    Sosnowski T.R., Vilkotsky A.I., Emeryk A.
    Book:
    Respiratory Drug Delivery 2022 (rok: 2022, tom: 1, strony: 551-554), Wydawca: RDD Online
    Status:
    Published

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