Projects funded by the NCN
The role of T regulatory lymphocytes and indoleamine 2,3-dioxygenase in shaping immunosuppressive microenvironment and in progression of chronic lymphocytic leukemia
2018/29/B/NZ6/01962
Keywords:
T regulatory cells indoleamine 2,3-dioxygenase chronic lymphocytic leukemia
Descriptors:
- NZ6_1: Adaptive and innate immunity
- NZ4_12: Other related subjects
- NZ3_14: Other related subjects
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Warszawski Uniwersytet Medyczny, Wydział Lekarski
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 15 - announced on 2018-03-15
Amount awarded: 1 928 850 PLN
Project start date (Y-m-d): 2019-02-13
Project end date (Y-m-d): 2023-02-12
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- FlowJo v10 Dongle.
- DELL OPTIPLEX 7060 Mini Tower z monitorem 24".
Information in the final report
- Publication in academic press/journals (2)
- The Role of Neutrophils in the Pathogenesis of Chronic Lymphocytic LeukemiaAuthors:Malgorzata Wachowska Alicja Wojciechowska Angelika MuchowiczAcademic press:International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 365-376), Wydawca: MDPIStatus:PublishedDOI:10.3390/ijms23010365 - link to the publication
- A Specific CD44lo CD25lo Subpopulation of Regulatory T Cells Inhibits Anti-Leukemic Immune Response and Promotes the Progression in a Mouse Model of Chronic Lymphocytic LeukemiaAuthors:Goral Agnieszka, Firczuk Malgorzata, Fidyt Klaudyna, Sledz Marta, Simoncello Francesca, Siudakowska Karolina, Pagano Giulia, Moussay Etienne, Paggetti Jérôme, Nowakowska Patrycja, Gobessi Stefania, Barankiewicz Joanna, Salomon-Perzynski Aleksander, Benvenuti Federica, Efremov Dimitar G., Juszczynski Przemyslaw, Lech-Maranda Ewa, Muchowicz AngelikaAcademic press:Frontiers in Immunology (rok: 2022, tom: 13, strony: 45306), Wydawca: FrontiersStatus:PublishedDOI:10.3389/fimmu.2022.781364 - link to the publication