Zmiana języka

Projects search

Phosphorylation of ribosomal P proteins as source of specialized ribosomes - new level of gene expression regulation in Eukaryotes

2018/29/B/NZ1/01728

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ1_2: Biochemia
  • NZ1_5: Inżynieria genetyczna

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Voivodeship: lubelskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Marek Tchórzewski

Number of co-investigators in the project: 6

Call

OPUS 15 – announced on 2018-03-15

Amount awarded
1 493 600 PLN
Project start date
2019-02-06
Project end date
2023-02-05
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Gradient Mixer. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (9)

  1. An Improved Vector System for Homogeneous and Stable Gene Regulation

    Authors:
    Barbara Michalec-Wawiórka, Jakub Czapiński, Kamil Filipek, Patrycja Rulak, Arkadiusz Czerwonka, Marek Tchórzewski, Adolfo Rivero-Müller
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22(10), pages: 5206), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22105206 – link to the publication

  2. Phosphorylation of the conserved C-terminal domain of ribosomal P-proteins impairs the mode of interaction with plant toxins

    Authors:
    Patrycja Horbowicz-Drożdżal, Karol Kamel, Sebastian Kmiecik, Lidia Borkiewicz, Nilgun E. Tumer, Pang-Chui Shaw, Marek Tchórzewski, Przemysław Grela
    Academic press:
    FEBS Letters (year: 2021, volume: 595(17), pages: 2221-2236), Publisher: WILEY
    Status:
    Published
    DOI:
    10.1002/1873-3468.14170 – link to the publication

  3. Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle

    Authors:
    Mateusz Mołoń, Eliza Molestak, Monika Kula-Maximenko, Przemysław Grela and Marek Tchórzewski
    Academic press:
    Cells (year: 2020, volume: 9(7), pages: 1745), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071745 – link to the publication

  4. Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome

    Authors:
    Kamil Filipek, Barbara Michalec-Wawiórka, Aleksandra Boguszewska, Sebastian Kmiecik and Marek Tchórzewski
    Academic press:
    FEBS Letter (year: 2020, volume: 594(18), pages: 3002-3019), Publisher: WILEY
    Status:
    Published
    DOI:
    10.1002/1873-3468.13885 – link to the publication

  5. Identification of a novel alternatively spliced isoform of the ribosomal uL10 protein

    Authors:
    Kamil Filipek, Kamil Deryło, Barbara Michalec-Wawiórka, Monika Zaciura, Alan González-Ibarra, Dawid Krokowski, Przemysław Latoch, Agata L Starosta, Jakub Czapiński, Adolfo Rivero-Müller, Leszek Wawiórka, Marek Tchórzewski
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (year: 2023, volume: 1866, pages: 194890), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2022.194890 – link to the publication

  6. Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction

    Authors:
    Arkadiusz W Kulczyk, Carlos Oscar S Sorzano, Przemysław Grela, Marek Tchórzewski, Nilgun E Tumer, Xiao-Ping Li
    Academic press:
    The Journal of Biological Chemistry (year: 2023, volume: 299, pages: 102795), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.102795 – link to the publication

  7. Sordarin— An anti-fungal antibiotic with a unique modus operandi

    Authors:
    Yutian Shao, Eliza Molestak, Weike Su, Marek Stankevič, Marek Tchórzewski
    Academic press:
    The British Journal of Pharmacology (year: 2022, volume: 179, pages: 1125-1145), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/bph.15724 – link to the publication

  8. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR

    Authors:
    Dawid Krokowski, Raul Jobava, Krzysztof J Szkop, Chien-Wen Chen, Xu Fu, Sarah Venus, Bo-Jhih Guan, Jing Wu, Zhaofeng Gao, Wioleta Banaszuk, Marek Tchorzewski, Tingwei Mu, Phil Ropelewski, William C Merrick, Yuanhui Mao, Aksoylu Inci Sevval, Helen Miranda, Shu-Bing Qian, Maria Manifava, Nicholas T Ktistakis, Anastasios Vourekas, Eckhard Jankowsky, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou
    Academic press:
    Cell Reports (year: 2022, volume: 40, pages: 111092), Publisher: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.111092 – link to the publication

  9. Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing

    Authors:
    Mateusz Mołoń, Karolina Stępień, Patrycja Kielar, Bela Vasileva, Bonka Lozanska, Dessislava Staneva, Penyo Ivanov, Monika Kula-Maximenko, Eliza Molestak, Marek Tchórzewski, George Miloshev, Milena Georgieva
    Academic press:
    Cells (year: 2022, volume: 11, pages: 2754), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11172754 – link to the publication

« New search

Graphic design and implementation: Jakub Piotrowski