Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Phosphorylation of ribosomal P proteins as source of specialized ribosomes - new level of gene expression regulation in Eukaryotes

2018/29/B/NZ1/01728

Keywords:

translation ribosome ribosomal proteins

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry
  • NZ1_5: Genetic engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Tchórzewski 

Number of co-investigators in the project: 6

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 493 600 PLN

Project start date (Y-m-d): 2019-02-06

Project end date (Y-m-d): 2023-02-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Gradient Mixer (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Cryo-EM structure of Shiga toxin 2 in complex with the native ribosomal P-stalk reveals residues involved in the binding interaction
    Authors:
    Arkadiusz W Kulczyk, Carlos Oscar S Sorzano, Przemysław Grela, Marek Tchórzewski, Nilgun E Tumer, Xiao-Ping Li
    Academic press:
    The Journal of Biological Chemistry (rok: 2023, tom: 299, strony: 102795), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.102795 - link to the publication
  2. Phosphorylation of the N-terminal domain of ribosomal P-stalk protein uL10 governs its association with the ribosome
    Authors:
    Kamil Filipek, Barbara Michalec-Wawiórka, Aleksandra Boguszewska, Sebastian Kmiecik and Marek Tchórzewski
    Academic press:
    FEBS Letter (rok: 2020, tom: 594(18), strony: 3002-3019), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/1873-3468.13885 - link to the publication
  3. Ribosomal Protein uL11 as a Regulator of Metabolic Circuits Related to Aging and Cell Cycle
    Authors:
    Mateusz Mołoń, Eliza Molestak, Monika Kula-Maximenko, Przemysław Grela and Marek Tchórzewski
    Academic press:
    Cells (rok: 2020, tom: 9(7), strony: 1745), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071745 - link to the publication
  4. Actin-Related Protein 4 and Linker Histone Sustain Yeast Replicative Ageing
    Authors:
    Mateusz Mołoń, Karolina Stępień, Patrycja Kielar, Bela Vasileva, Bonka Lozanska, Dessislava Staneva, Penyo Ivanov, Monika Kula-Maximenko, Eliza Molestak, Marek Tchórzewski, George Miloshev, Milena Georgieva
    Academic press:
    Cells (rok: 2022, tom: 11, strony: 2754), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11172754 - link to the publication
  5. Identification of a novel alternatively spliced isoform of the ribosomal uL10 protein
    Authors:
    Kamil Filipek, Kamil Deryło, Barbara Michalec-Wawiórka, Monika Zaciura, Alan González-Ibarra, Dawid Krokowski, Przemysław Latoch, Agata L Starosta, Jakub Czapiński, Adolfo Rivero-Müller, Leszek Wawiórka, Marek Tchórzewski
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (rok: 2023, tom: 1866, strony: 194890), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2022.194890 - link to the publication
  6. Phosphorylation of the conserved C-terminal domain of ribosomal P-proteins impairs the mode of interaction with plant toxins
    Authors:
    Patrycja Horbowicz-Drożdżal, Karol Kamel, Sebastian Kmiecik, Lidia Borkiewicz, Nilgun E. Tumer, Pang-Chui Shaw, Marek Tchórzewski, Przemysław Grela
    Academic press:
    FEBS Letters (rok: 2021, tom: 595(17), strony: 2221-2236), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/1873-3468.14170 - link to the publication
  7. An Improved Vector System for Homogeneous and Stable Gene Regulation
    Authors:
    Barbara Michalec-Wawiórka, Jakub Czapiński, Kamil Filipek, Patrycja Rulak, Arkadiusz Czerwonka, Marek Tchórzewski, Adolfo Rivero-Müller
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(10), strony: 5206), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22105206 - link to the publication
  8. Sordarin— An anti-fungal antibiotic with a unique modus operandi
    Authors:
    Yutian Shao, Eliza Molestak, Weike Su, Marek Stankevič, Marek Tchórzewski
    Academic press:
    The British Journal of Pharmacology (rok: 2022, tom: 179, strony: 1125-1145), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/bph.15724 - link to the publication
  9. Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR
    Authors:
    Dawid Krokowski, Raul Jobava, Krzysztof J Szkop, Chien-Wen Chen, Xu Fu, Sarah Venus, Bo-Jhih Guan, Jing Wu, Zhaofeng Gao, Wioleta Banaszuk, Marek Tchorzewski, Tingwei Mu, Phil Ropelewski, William C Merrick, Yuanhui Mao, Aksoylu Inci Sevval, Helen Miranda, Shu-Bing Qian, Maria Manifava, Nicholas T Ktistakis, Anastasios Vourekas, Eckhard Jankowsky, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou
    Academic press:
    Cell Reports (rok: 2022, tom: 40, strony: 111092), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.111092 - link to the publication

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