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Information of the project and the call

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The role of MCPIP-1 the negative regulator of inflammatory state in periodontitis development

2018/29/B/NZ6/01622

Keywords:

MCPIP-1 periodontitis inflammation

Descriptors:

  • NZ6_1:
  • NZ6_4:
  • NZ3_7:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Kozieł 

Number of co-investigators in the project: 3

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 803 000 PLN

Project start date (Y-m-d): 2019-02-04

Project end date (Y-m-d): 2023-12-03

Project duration:: 58 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (1)
  1. MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils.
    Authors:
    Dobosz E, Wadowska M, Kaminska M, Wilamowski M, Honarpisheh M, Bryzek D, Potempa J, Jura J, Lech M, Koziel J.
    Academic press:
    Front Immunol. (rok: 2021, tom: 12, strony: 627922), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.627922. - link to the publication
  2. Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis
    Authors:
    Golda A, Gasiorek A, Dobosz E, Oruba Z, Lamont R, Potempa J, Koziel J
    Academic press:
    Journal of Oral Microbiology (rok: 2024, tom: 16, strony: 45671), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/20002297.2023.2292382 - link to the publication
  3. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.
    Authors:
    Dobosz E, Lorenz G, Ribeiro A, Würf V, Wadowska M, Kotlinowski J, Schmaderer C, Potempa J, Fu M, Koziel J, Lech M.
    Academic press:
    Dis Model Mech. (rok: 2021, tom: 14(3), strony: dmm047589.), Wydawca: The company biologist
    Status:
    Published
    DOI:
    10.1242/dmm.047589 - link to the publication
  4. Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis.
    Authors:
    Ciaston I, Budziaszek J, Satala D, Potempa B, Fuchs A, Rapala-Kozik M, Mizgalska D, Dobosz E, Lamont RJ, Potempa J, Koziel J.
    Academic press:
    mBIO (rok: 2022, tom: 28;13(3), strony: e0378721), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/mbio.03787-21 - link to the publication
  5. Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts.
    Authors:
    Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J.
    Academic press:
    mBio (rok: 2021, tom: 12(3), strony: e0050221.), Wydawca: American Society of Microbiology
    Status:
    Published
    DOI:
    10.1128/mBio.00502-21 - link to the publication
  6. MCP-Induced Protein 1 Participates in Macrophage-Dependent Endotoxin Tolerance.
    Authors:
    Wadowska M, Dobosz E, Golda A, Bryzek D, Lech M, Fu M, Koziel J.
    Academic press:
    J Immunol (rok: 2022, tom: 1;209(7), strony: 1348-1358), Wydawca: The American Association of Immunologists
    Status:
    Published
    DOI:
    10.4049/jimmunol.2101184 - link to the publication
  7. Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis.
    Authors:
    Kotlinowski J, Hutsch T, Czyzynska-Cichon I, Wadowska M, Pydyn N, Jasztal A, Kij A, Dobosz E, Lech M, Miekus K, Pośpiech E, Fu M, Jura J, Koziel J, Chlopicki S.
    Academic press:
    Biochim Biophys Acta Mol Basis Dis. (rok: 2021, tom: 1867(5), strony: 166086), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2021.166086. - link to the publication
  8. The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases
    Authors:
    Ciastoń I, Dobosz E, Potempa J, Koziel J
    Academic press:
    Molecular Aspects of Medicine (rok: 2022, tom: 88, strony: 101143), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mam.2022.101143 - link to the publication
  1. The novel virulence strategies of Porphyromonas gingivalis, a pivotal periodontal pathogen
    Authors:
    Joanna Kozieł
    Conference:
    8th International Weigl Conference (rok: 2019, ), Wydawca: Grupa Medica s.c.
    Data:
    konferencja 2019-06-26 - 2019-06-28
    Status:
    Published

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