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The role of MCPIP-1 the negative regulator of inflammatory state in periodontitis development

2018/29/B/NZ6/01622

Keywords

Descriptors

  • NZ6_1: Odporność swoista i nieswoista
  • NZ6_4: Bakteriologia
  • NZ3_7: Przekaźnictwo sygnału

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Joanna Kozieł

Number of co-investigators in the project: 3

Call

OPUS 15 – announced on 2018-03-15

Amount awarded
1 803 000 PLN
Project start date
2019-02-04
Project end date
2023-12-03
Project duration
58 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (8)

  1. Murine myeloid cell MCPIP1 suppresses autoimmunity by regulating B-cell expansion and differentiation.

    Authors:
    Dobosz E, Lorenz G, Ribeiro A, Würf V, Wadowska M, Kotlinowski J, Schmaderer C, Potempa J, Fu M, Koziel J, Lech M.
    Academic press:
    Dis Model Mech. (year: 2021, volume: 14(3), pages: dmm047589.), Publisher: The company biologist
    Status:
    Published
    DOI:
    10.1242/dmm.047589 – link to the publication

  2. Organotypic model of the gingiva for studying bacterial and viral pathogens implicated in periodontitis

    Authors:
    Golda A, Gasiorek A, Dobosz E, Oruba Z, Lamont R, Potempa J, Koziel J
    Academic press:
    Journal of Oral Microbiology (year: 2024, volume: 16, pages: 46036), Publisher: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/20002297.2023.2292382 – link to the publication

  3. MCPIP-1 Restricts Inflammation via Promoting Apoptosis of Neutrophils.

    Authors:
    Dobosz E, Wadowska M, Kaminska M, Wilamowski M, Honarpisheh M, Bryzek D, Potempa J, Jura J, Lech M, Koziel J.
    Academic press:
    Front Immunol. (year: 2021, volume: 12, pages: 627922), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.627922. – link to the publication

  4. Subversion of Lipopolysaccharide Signaling in Gingival Keratinocytes via MCPIP-1 Degradation as a Novel Pathogenic Strategy of Inflammophilic Pathobionts.

    Authors:
    Gasiorek A, Dobosz E, Potempa B, Ciaston I, Wilamowski M, Oruba Z, Lamont RJ, Jura J, Potempa J, Koziel J.
    Academic press:
    mBio (year: 2021, volume: 12(3), pages: e0050221.), Publisher: American Society of Microbiology
    Status:
    Published
    DOI:
    10.1128/mBio.00502-21 – link to the publication

  5. Deletion of Mcpip1 in Mcpip1fl/flAlbCre mice recapitulates the phenotype of human primary biliary cholangitis.

    Authors:
    Kotlinowski J, Hutsch T, Czyzynska-Cichon I, Wadowska M, Pydyn N, Jasztal A, Kij A, Dobosz E, Lech M, Miekus K, Pośpiech E, Fu M, Jura J, Koziel J, Chlopicki S.
    Academic press:
    Biochim Biophys Acta Mol Basis Dis. (year: 2021, volume: 1867(5), pages: 166086), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2021.166086. – link to the publication

  6. Proteolytic Activity-Independent Activation of the Immune Response by Gingipains from Porphyromonas gingivalis.

    Authors:
    Ciaston I, Budziaszek J, Satala D, Potempa B, Fuchs A, Rapala-Kozik M, Mizgalska D, Dobosz E, Lamont RJ, Potempa J, Koziel J.
    Academic press:
    mBIO (year: 2022, volume: 28;13(3), pages: e0378721), Publisher: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/mbio.03787-21 – link to the publication

  7. MCP-Induced Protein 1 Participates in Macrophage-Dependent Endotoxin Tolerance.

    Authors:
    Wadowska M, Dobosz E, Golda A, Bryzek D, Lech M, Fu M, Koziel J.
    Academic press:
    J Immunol (year: 2022, volume: 1;209(7), pages: 1348-1358), Publisher: The American Association of Immunologists
    Status:
    Published
    DOI:
    10.4049/jimmunol.2101184 – link to the publication

  8. The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseases

    Authors:
    Ciastoń I, Dobosz E, Potempa J, Koziel J
    Academic press:
    Molecular Aspects of Medicine (year: 2022, volume: 88, pages: 101143), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mam.2022.101143 – link to the publication

Articles in post-conference publications (1)

  1. The novel virulence strategies of Porphyromonas gingivalis, a pivotal periodontal pathogen

    Authors:
    Joanna Kozieł
    Conference:
    8th International Weigl Conference (year: 2019, pages: 36), Publisher: Grupa Medica s.c.
    Date:
    conference 2019-06-26 - 2019-06-28
    Status:
    Published

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