Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Cooridination of innate immune response in infected cell population: experiment and mathematical modeling

2018/29/B/NZ2/00668

Keywords:

cytokine signaling low multiplicity of infection single-cell experiments mathematical modeling stochastic processes RSV influenza A549 cell line

Descriptors:

  • NZ2_9: Systems biology
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tomasz Lipniacki 

Number of co-investigators in the project: 6

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 136 000 PLN

Project start date (Y-m-d): 2019-01-31

Project end date (Y-m-d): 2022-12-30

Project duration:: 47 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora lamininarna.
  2. Inkubator CO2.
  3. Mikroskop.
  4. Zbiornik niskociśnieniowy do przechowywania ciekłego azotu.
  5. Pipety.
  6. Ssak laboratoryjny.
  7. Wirówka uniwersalna z chłodzeniem.
  8. ChemiDoc (170 000 PLN)
  9. Lodówko-zamrażarka laboratoryjna.
  10. Vortex.
  11. Wirówka podręczna.

Information in the final report

  • Publication in academic press/journals (9)
  1. Antagonism between viral infection and innate immunity at the single-cell level
    Authors:
    Frederic Grabowski, Marek Kochańczyk, Zbigniew Korwek, Maciej Czerkies, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    PLOS Pathogens (rok: 2023, tom: 19, strony: e1011597), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1011597 - link to the publication
  2. Super-spreading events initiated the exponential growth phase of COVID-19 with ℛ 0 higher than initially estimated
    Authors:
    Marek Kochanczyk, Frederic Grabowski, Tomasz Lipniacki
    Academic press:
    Royal Society Open Science (rok: 2020, tom: 7, strony: 7(9):200786), Wydawca: Royal Society
    Status:
    Published
    DOI:
    10.1098/rsos.200786 - link to the publication
  3. Respiratory syncytial virus protects bystander cells against influenza A virus infection by triggering secretion of type I and type III interferons
    Authors:
    Maciej Czerkies, Marek Kochańczyk, Zbigniew Korwek, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    Journal of Virology (rok: 2022, tom: 96, strony: e01341-22), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/jvi.01341-22 - link to the publication
  4. The spread of SARS-CoV-2 variant Omicron with a doubling time of 2.0–3.3 days can be explained by immune evasion
    Authors:
    Frederic Grabowski, Marek Kochańczyk, Tomasz Lipniacki
    Academic press:
    Viruses (rok: 2022, tom: 14, strony: 294), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/v14020294 - link to the publication
  5. Non-self RNA rewires IFNβ signaling: A mathematical model of the innate immune response
    Authors:
    Zbigniew Korwek, Maciej Czerkies, Joanna Jaruszewicz-Błońska, Wiktor Prus, Ilona Kosiuk, Marek Kochańczyk, Tomasz Lipniacki
    Academic press:
    Science Signaling , Wydawca: American Association for the Advancement of Science
    Status:
    Accepted for publication
    DOI:
    10.1101/2022.01.30.478391 - link to the publication
  6. A plausible identifiable model of the canonical NF-κB signaling pathway
    Authors:
    Joanna Jaruszewicz-Błońska, Ilona Kosiuk, Wiktor Prus, Tomasz Lipniacki
    Academic press:
    PLOS One (rok: 2023, tom: 18, strony: e0286416), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0286416 - link to the publication
  7. Dynamics of COVID-19 pandemic at constant and time-dependent contact rates
    Authors:
    Marek Kochanczyk, Frederic Grabowski, Tomasz Lipniacki
    Academic press:
    Mathematical Models of Natural Phenomena (rok: 2020, tom: 15, strony: e1-e12), Wydawca: EDP Scienecs
    Status:
    Published
    DOI:
    10.1051/mmnp/2020011 - link to the publication
  8. Electrochemical immunosensors based on screen-printed gold and glassy carbon electrodes: Comparison of performance for respiratory syncytial virus detection
    Authors:
    Białobrzeska, W.; Firganek, D.; Czerkies, M.; Lipniacki, T.; Skwarecka, M.; Dziąbowska, K.; Cebula, Z.; Malinowska, N.; Bigus, D.; Bięga, E.; Pyrć, K.; Pala, K.; Żołędowska, S.; Nidzworski, D
    Academic press:
    Biosensors (rok: 2020, tom: 10, strony: 175), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/bios10110175 - link to the publication
  9. Pareto-based evaluation of national responses to COVID-19 pandemic shows that saving lives and protecting economy are non-trade-off objectives
    Authors:
    Marek Kochanczyk, Tomasz Lipniacki
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 11(1):2425), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-021-81869-2 - link to the publication

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