Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Molecular analysis of the structural disorder of the Nucleobindin-2, a protein with multiple functions

2018/29/B/NZ1/02574

Keywords:

nucleobindin nesfatin intrinsically disordered proteins intrinsically disordered regions circular dichroism AUC SAXS HDX calcium ions binding

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_3: Biophysics
  • NZ1_4: Structural biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Ożyhar 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 258 000 PLN

Project start date (Y-m-d): 2019-05-06

Project end date (Y-m-d): 2023-05-05

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Licznik komórek TC20 Auto Cell Counter & Cell Count.
  2. Wytwornica lodu.
  3. Urządzenie do Real-time PCR (250 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Nucleobindin-2 consists of two structural components: The Zn2+-sensitive N-terminal half, consisting of nesfatin-1 and -2, and the Ca2+-sensitive C-terminal half, consisting of nesfatin-3
    Authors:
    Bystranowska D, Skorupska A, Sołtys K, Padjasek M, Krężel A, Żak A, Kaus-Drobek M, Taube M, Kozak M, Ożyhar A.
    Academic press:
    Comput Struct Biotechnol J. (rok: 2021, tom: 19, strony: 4300-4318), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2021.07.036 - link to the publication
  2. Nesfatin-3 possesses divalent metal ion binding properties, which remain hidden in the nucleobindin-2 precursor protein
    Authors:
    Anna Skorupska-Stasiak, Dominika Bystranowska, Józef Ba Tran, Artur Krężel, Andrzej Ożyhar
    Academic press:
    Cell Communications and Signaling , Wydawca: Springer Nature
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  3. The multifaceted nature of Nucleobindin-2 in carcinogenesis
    Authors:
    Anna Skorupska, Rafał Lenda, Andrzej Ożyhar, Dominika Bystranowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 225687, strony: 45306), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22115687 - link to the publication
  4. Calcium ions modulate the structure of the intrinsically disordered Nucleobindin-2 protein
    Authors:
    Anna Skorupska, Dominika Bystranowska, Katarzyna Dąbrowska, Andrzej Ożyhar
    Academic press:
    International Journal of Biological Macromolecules (rok: 2020, tom: 154, strony: 1091-1104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2020.03.110 - link to the publication
  5. Does one plus one always equal two? Structural differences between nesfatin-1, -2, and nesfatin-1/2
    Authors:
    Rafał Lenda, Michał Padjasek, Artur Krężel, Andrzej Ożyhar, Dominika Bystranowska
    Academic press:
    Cell Communication and Signaling (rok: 2022, tom: 20, strony: 45310), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-022-00980-7 - link to the publication
  1. Conformational changes of nesfatin-1 in the presence of Zn(II) ions
    Authors:
    R. Lenda, A. Ozyhar, D. Bystranowska
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: FEBS Open Bio © 2021 FEBS Wiley
    Data:
    konferencja 2021-07-03 - 2021-07-08
    Status:
    Published
    DOI:
    link to the publication
  2. The Zn2+ -dependent change of Nucleobindin-2 structure
    Authors:
    A. Skorupska, M. Kaus -Drobek, A. Ozyhar, D. Bystranowska
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: FEBS Open Bio © 2021 FEBS Wiley
    Data:
    konferencja 2021-07-03 - 2021-07-08
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy