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Dissecting the mechanisms of proteolytic cross-talk underlying pyroptosis, a programmed inflammatory cell death.

2018/29/B/NZ1/02249

Keywords:

cell death pyroptosis inflammation gasdermin D proteolytic enzymes fluorogenic substrates

Descriptors:

  • NZ3_3:
  • ST5_16:
  • NZ1_2:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Łukasz Poręba 

Number of co-investigators in the project: 4

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 280 000 PLN

Project start date (Y-m-d): 2019-02-01

Project end date (Y-m-d): 2022-07-31

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Recent advances in the development of legumain-selective chemical probes and peptide prodrugs
    Authors:
    Poreba M
    Academic press:
    Biological Chemistry (rok: 2019, tom: 400, strony: 1529-1550), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/hsz-2019-0135 - link to the publication
  2. Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
    Authors:
    Bibo-Verdugo B, Jogleker I, Giridhar M, Ramirez, ML, Snipas SJ, Clark AC, Poreba M, Salvesen GS
    Academic press:
    Journal of Biological Chemistry (rok: 2022, tom: 298, strony: 101931), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbc.2022.101931 - link to the publication
  3. Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells
    Authors:
    Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drag M, Poreba M
    Academic press:
    Cell Death and Differentiation (rok: 2019, tom: 27, strony: 451-465), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41418-019-0364-z - link to the publication
  4. Diagnostic and therapeutic potential of protease inhibition
    Authors:
    Ćwilichowska N, Świderska KW, Dobrzyń A, Drąg M, PorębaM
    Academic press:
    Molecular Aspects of Medicine (rok: 2022, tom: 88, strony: 101144), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mam.2022.101144 - link to the publication
  5. Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells
    Authors:
    Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drag M, Poreba M
    Academic press:
    Cell Death and Differentiation (rok: 2019, tom: 27, strony: 451-465), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41418-019-0364-z - link to the publication
  6. Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11
    Authors:
    Bibo-Verdugo B, Snipas SJ, Kolt S, Poreba M, Salvesen GS
    Academic press:
    Journal of Biological Chemistry (rok: 2020, tom: 295, strony: 11292-11302), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.RA120.014259 - link to the publication

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