Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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BCR-ABL-containing leukemic extracellular vesicles as a novel, immunosuppressive factor controlling function of regulatory T cells

2018/29/N/NZ3/01754

Keywords:

CML leukemia extracellular vesicles regulatory T cell BCR-ABL Foxp3 immunosuppression

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Julian Swatler 

Number of co-investigators in the project: 2

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2019-01-14

Project end date (Y-m-d): 2022-01-13

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop Apple 13 MacBook Pro.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (8)
  1. Chronic myeloid leukemia‐derived extracellular vesicles increase Foxp3 level and suppressive activity of thymic regulatory T cells
    Authors:
    Julian Swatler, Wioleta Dudka, Lukasz Bugajski, Marta Brewinska‐Olchowik, Ewa Kozlowska, Katarzyna Piwocka
    Academic press:
    European Journal of Immunology (rok: 2019, tom: [Epub ahead], strony: [Epub ahead of print]), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/eji.201848051 - link to the publication
  2. 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells
    Authors:
    Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara De Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza and Katarzyna Piwocka
    Academic press:
    Blood Advances (rok: 2022, tom: -, strony: -), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/bloodadvances.2021006195 - link to the publication
  3. Immunosuppressive cell subsets and factors in myeloid leukemias
    Authors:
    Julian Swatler, Laura Turos-Korgul, Ewa Kozlowska, Katarzyna Piwocka
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 1203), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13061203 - link to the publication
  4. Isolation and Characterization of Extracellular Vesicles from Cell Culture Conditioned Medium for Immunological Studies
    Authors:
    Julian Swatler, Wioleta Dudka, Katarzyna Piwocka
    Academic press:
    Current Protocols in Immunology (rok: 2020, tom: 129(1), strony: e96), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cpim.96 - link to the publication
  1. Functional and proteomic insight into modulation of Foxp3+ regulatory T cells by leukemic extracellular vesicles
    Authors:
    Julian Swatler, Laura Turos, Dominik Cysewski, Marta Brewinska-Olchowik, Ewa Kozlowska, Paulina Pilanc, Katarzyna Piwocka
    Conference:
    CYTO Virtual 2020 (rok: 2020, ), Wydawca: ISAC
    Data:
    konferencja 4-5.08.2020
    Status:
    Published
  2. Leukemic extracellular vesicles as drivers of Foxp3+ regulatory T cells differentiation and activity – functional and proteomic studies
    Authors:
    Julian Swatler, Laura Turos, Dominik Cysewski, Marta Brewinska-Olchowik, Ewa Kozlowska, Katarzyna Piwocka
    Conference:
    GENE EXPRESSION & SIGNALING IN THE IMMUNE SYSTEM (rok: 2020, ), Wydawca: Cold Spring Harbor Laboratory
    Data:
    konferencja 13-16.10.2020
    Status:
    Published
  3. Novel role of BCR-ABL-containing leukemic extracellular vesicles in controlling the function of regulatory T cells
    Authors:
    Julian Swatler, Wioleta Dudka-Ruszkowska, Lukasz Bugajski, Ewa Kozlowska & Katarzyna Piwocka
    Conference:
    ISEV 2019 Annual Meeting (rok: 2019, ), Wydawca: Taylor & Francis
    Data:
    konferencja 2019-04-25-28
    Status:
    Published
  4. High resolution spectral flow cytometry reveals effector subsets of human regulatory T cells driven by myeloid leukemia-derived extracellular vesicles
    Authors:
    Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Katarzyna Piwocka
    Conference:
    Cyto Virtual Interactive 2021 (rok: 2021, ), Wydawca: ISAC
    Data:
    konferencja 7-10.06.2021
    Status:
    Published
  5. Leukemic extracellular vesicles drive highly suppressive regulatory T cells by modulating mTOR and STAT5 signaling, leading to progression of myeloid leukemia
    Authors:
    Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara de Biasi, Wioleta Dudka, Agata Kominek, Salwador Cyranowski, Jakub Mieczkowski, Elyas Mohammadi, Ewa Kozlowska, Andrea Cossarizza, Katarzyna Piwocka
    Conference:
    6th European Congress of Immunology (rok: 2021, ), Wydawca: EFIS
    Data:
    konferencja 1-4.09.2021
    Status:
    Published
  6. Leukemic extracellular vesicles, containing 4-1BBL protein, promote immunosuppressive effector regulatory T cells
    Authors:
    Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara de Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc-Kudlek, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza, Katarzyna Piwocka
    Conference:
    Translational Immunology (rok: 2021, ), Wydawca: VIB Ghent
    Data:
    konferencja 22-23.11.2021
    Status:
    Published
  7. BCR-ABL-containing leukemic extracellular vesicles contribute to immunosuppression in chronic myeloid leukemia by controlling expression of Foxp3 and biology of regulatory T cells
    Authors:
    Swatler J., Bugajski L., Dudka W., Turos L., Kozłowska E., Piwocka K
    Conference:
    CYTO 2019 – 34th Congress of the International Society for Advancement of Cytometry (rok: 2019, ), Wydawca: ISAC
    Data:
    konferencja 2019-06-22-26
    Status:
    Published
  8. Leukemic extracellular vesicles upregulate highly suppressive regulatory T cells by modulating mTOR and STAT5 signaling, leading to progression of CML
    Authors:
    Swatler J., Turos-Korgul L., Brewinska-Olchowik M., de Biasi S., Dudka W., Kominek A., Le BV., Cyranowski S., Mieczkowski J., Mohammadi E., Kozlowska E., Cossarizza A., Piwocka K.
    Conference:
    23rd Annual John Goldman E-Conference on Chronic Myeloid Leukemia: Biology and Therapy (rok: 2021, ), Wydawca: European School of Hematology
    Data:
    konferencja 7-10.10.2021
    Status:
    Published