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Investigation of involvement of particular TET protein family members in the generation of epigenetic DNA modyfications.

2018/29/N/NZ1/00497

Keywords:

active demethylation methylation TET

Descriptors:

  • NZ1_2:
  • NZ1_1:
  • NZ3_1:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Maciej Tomasz Gawroński 

Number of co-investigators in the project: 3

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 210 000 PLN

Project start date (Y-m-d): 2019-03-12

Project end date (Y-m-d): 2023-03-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (5)
  1. Loss of TET2 activity limits the ability of vitamin C to activate DNA demethylation in human HAP1 cells
    Authors:
    Maciej Gawronski, Marta Starczak, Aleksandra Wasilow, Tomasz Dziaman, Ryszard Olinski, Daniel Gackowski
    Status:
    Accepted for publication
  1. LIPOSOMAL VITAMIN C AS AN ATRACTIVE ALTERNATIVE FOR ASCORBIC ACID SUPPLEMENTATION IN CELL CULTURE
    Authors:
    Maciej Gawroński, Patrycja Bagińska, Marta Starczak, Aleksandra Wasilów, Daniel Gackowski
    Conference:
    Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022 (rok: 2022, ), Wydawca: Tissue Engineering and Regenerative Medicine International Society
    Data:
    konferencja 28.06-01.07.2022
    Status:
    Published
  2. Comparison of the of 5-methylcytosine derivates changes in the dna of chronic myeloid leukemia cell line after exposure to various forms of vitamin C
    Authors:
    Bagińska Patrycja, Gawroński Maciej, Starczak Marta, Szpotan Justyna, Wasilów Aleksandra, Mijewski Paweł
    Conference:
    National Scientific Conference Second Summer Scientific On-line School August 07, 2021 (rok: 2021, ), Wydawca: Promovendi Foundation Publishing
    Data:
    konferencja 07.08.2021
    Status:
    Published
  3. Vitamin C supplementation - A necessity for optimal TET protein activity in in vitro cell models?
    Authors:
    Maciej Gawroński, Patrycja Bagińska, Marta Starczak, Aleksandra Wasilów, Paweł Mijewski, Fabian Leśniewski, Aleksandra Skalska-Bugała, Daniel Gackowski
    Conference:
    1st Epigenetics Society International Meeting Epigenetics of Disease and Development (rok: 2023, ), Wydawca: Epigenetics Society (ES). (2023)
    Data:
    konferencja 12-14.10.2023
    Status:
    Published
  4. Vitamin C as a key regulatur of the active DNA demethylation process
    Authors:
    Maciej Gawroński
    Conference:
    XXVI Gliwice scientific meetings (rok: 2022, ), Wydawca: Maria Skłodowska-Curie National Research Institute of Oncology, Gliwice Branch i Silesian University of Technology
    Data:
    konferencja 18-19.11.2022
    Status:
    Published
  5. Effects of different forms of vitamin C on epigenetic DNA modification levels in the cellular model of chronic myeloid leukemia
    Authors:
    Patrycja Bagińska, Maciej Gawroński, Marta Starczak, Justyna Szpotan, Aleksandra Wasilów, Paweł Mijewski, Daniel Gackowski
    Conference:
    1 st International Scientific Conference Advances in biomedical research with use of in vitro methods (rok: 2021, ), Wydawca: Foundation for the promotion of science and development TYGIEL
    Data:
    konferencja 17.07.2021
    Status:
    Published

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