Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Novel molecular mechanisms in extracellular copper transport

2018/29/B/ST4/01634

Keywords:

copper kinetoics complex formation peptides proteins

Descriptors:

  • NZ1_3: Biophysics
  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST5_14: Other related subjects

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Bal 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 522 000 PLN

Project start date (Y-m-d): 2019-01-15

Project end date (Y-m-d): 2023-01-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Hierarchical binding of copper II to N-truncated Ab4–16 peptide
    Authors:
    X. Teng, E. Stefaniak, P. Girvan, R. Kotuniak, D. Ponka, W. Bal, L. Ying
    Academic press:
    Metallomics (rok: 2020, tom: 12, strony: 470-473), Wydawca: Royal Society of Chemistry (UK)
    Status:
    Published
    DOI:
    10.1039/c9mt00299e - link to the publication
  2. Kinetics of Cu(II) complexation by ATCUN/NTS and related peptides: a gold mine of novel ideas for copper biology
    Authors:
    Radosław Kotuniak, Wojciech Bal
    Academic press:
    Dalton Transactions (rok: 2022, tom: 51, strony: 14-26), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d1dt02878b - link to the publication
  3. Copper Transporters? Glutathione Reactivity of Products of Cu–Aβ Digestion by Neprilysin
    Authors:
    E. stefaniak, D. Płonka, P. Szczerba, N. E. Wezynfld, W. Bal
    Academic press:
    Inorg. Chem. (rok: 2020, tom: 59, strony: 4186-4190), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.0c00427 - link to the publication
  4. Interactions of neurokinin B with copper(II) ions and their potential biological consequences
    Authors:
    K. Stokowa-Sołtys, K. Szczerba, M. Pacewicz, R. Wieczorek, N.E. Wezynfeld, W. Bal
    Academic press:
    Dalton Transactions (rok: 2022, tom: 51, strony: 14267–14276), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/D2DT02033E - link to the publication
  5. Key intermediate species reveal the Cu(II) exchange pathway in biorelevant ATCUN/NTS complexes
    Authors:
    R. Kotuniak, M. J. F. Strampraad, K. Bossak-Ahmad, I. Ufnalska, U. Wawrzyniak, P.-L. Hagedoorn, W. Bal
    Academic press:
    Angew. Chem. Int. Ed. (rok: 2020, tom: 59, strony: 11234-11239), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.202004264 - link to the publication
  6. Reactive Cu2+-peptide intermediates revealed by kinetic studies gain relevance by matching time windows in copper metallomics
    Authors:
    R. Kotuniak, W. Bal
    Academic press:
    Metallomics (rok: 2023, tom: 15, strony: mfad007), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/mtomcs/mfad007 - link to the publication
  7. Intermediate Cu(II)-Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction
    Authors:
    Iwona Ufnalska, Simon C. Drew, Igor Zhukov, Kosma Szutkowski, Urszula E. Wawrzyniak, Wojciech Wróblewski, Tomasz Frączyk, Wojciech Bal
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 18048−18057), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c02669 - link to the publication

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