Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Purinergic signaling as important regulator of hematopoietic system

2018/29/B/NZ4/01470

Keywords:

extracellular nucleotides purinergic signaling hematopoietic stem cells mobilization/engraftment of hematopoietic stem cells

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_8: Stem cell biology
  • NZ4_2: Physiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Ratajczak 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 2 828 700 PLN

Project start date (Y-m-d): 2019-02-04

Project end date (Y-m-d): 2023-02-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażarka niskotemperaturowa (-80 stopni) (60 000 PLN)
  2. PCR emulsyjny (160 000 PLN)
  3. Zamrażarka (-20C) (4 000 PLN)
  4. Automatyczny Licznik Komórek (15 000 PLN)
  5. Lodówka (+4C) (2 500 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  1. NLRP3 inflammasome couples purinergic signaling with activation of the complement cascade for the optimal release of cells from bone marrow
    Authors:
    Mariusz Z. Ratajczak, Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Anna M. Lenkiewicz
    Academic press:
    Leukemia (rok: 2019, tom: 33, strony: 815-825), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41375-019-0436-6 - link to the publication
  2. The Nlrp3 Inflammasome Orchestrates Mobilization of Bone Marrow-Residing Stem Cells into Peripheral Blood
    Authors:
    Anna M. Lenkiewicz, Mateusz Adamiak, Arjun Thapa, Kamila Bujko, Daniel Pedziwiatr, Ahmed K. Abdel-Latif, Magda Kucia, Janina Ratajczak, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Reviews (rok: 2019, tom: 15, strony: 391-403), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-019-09890-7 - link to the publication
  3. The Nlrp3 inflammasome - the evolving story of its positive and negative effects on hematopoiesis.
    Authors:
    Ratajczak, Mariusz Z, Magdalena Kucia
    Academic press:
    Current opinion in hematology (rok: 2021, tom: 28, strony: 251-261), Wydawca: Wolters Kluwer Health
    Status:
    Published
    DOI:
    10.1097/MOH.0000000000000658 - link to the publication
  4. The P2X4 purinergic receptor has emerged as a potent regulator of hematopoietic stem/progenitor cell mobilization and homing-a novel view of P2X4 and P2X7 receptor interaction in orchestrating stem cell trafficking.
    Authors:
    Adamiak M, Bujko K, Thapa A, Pensato V, Brzezniakiewicz-Janus K, Ratajczak J, Davies DL, Ulrich H, Kucia M, Ratajczak MZ.
    Academic press:
    Leukamia (rok: 2022, tom: 36, strony: 248-256), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41375-021-01352-9 - link to the publication
  5. Hematopoiesis and innate immunity: an inseparable couple for good and bad times, bound together by an hormetic relationship.
    Authors:
    Ratajczak MZ, Kucia M.
    Academic press:
    Leukemia (rok: 2022, tom: 36, strony: 23-32), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41375-021-01482-0 - link to the publication
  6. Extracellular Adenosine Triphosphate (eATP) and Its Metabolite, Extracellular Adenosine (eAdo), as Opposing Yin–Yang" Regulators of Nlrp3 Inflammasome in the Trafficking of Hematopoietic Stem/Progenitor Cells
    Authors:
    Mariusz Z. Ratajczak, Magda Kucia
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 11, strony: 603942), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.603942 - link to the publication
  7. Novel evidence that an alternative complement cascade pathway is involved in optimal mobilization of hematopoietic stem/progenitor cells in Nlrp3 inflammasome-dependent manner
    Authors:
    Mateusz Adamiak, Anna M. Lenkiewicz, Monika Cymer, Magda Kucia, Janina Ratajczak, Mariusz Z. Ratajczak
    Academic press:
    Leukemia (rok: 2019, tom: 33, strony: 2967-2970), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41375-019-0530-9 - link to the publication
  8. Danger-associated molecular pattern molecules take unexpectedly a central stage in Nlrp3 inflammasome–caspase-1-mediated trafficking of hematopoietic stem/progenitor cells
    Authors:
    Arjun Thapa, Mateusz Adamiak, Kamila Bujko, Janina Ratajczak, Ahmed K. Abdel-Latif, Magda Kucia, Mariusz Z. Ratajczak
    Academic press:
    Leukemia (rok: 2021, tom: 35, strony: 2658-2671), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-021-01158-9 - link to the publication
  9. Extracellular Adenosine Triphosphate (eATP) and Its Metabolite, Extracellular Adenosine (eAdo), as Opposing "Yin-Yang" Regulators of Nlrp3 Inflammasome in the Trafficking of Hematopoietic Stem/Progenitor Cells.
    Authors:
    Ratajczak, Mariusz Z, Magda Kucia
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 11, strony: 603942), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.603942 - link to the publication
  10. Novel Evidence That Alternative Pathway of Complement Cascade Activation is Required for Optimal Homing and Engraftment of Hematopoietic Stem/progenitor Cells.
    Authors:
    Adamiak M, Ciechanowicz A, Chumak V, Bujko K, Ratajczak J, Brzezniakiewicz-Janus K, Kucia M, Ratajczak MZ.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2022, tom: 18, strony: 1355-1365), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-021-10318-4 - link to the publication
  11. The Nlrp3 inflammasome as a rising star" in studies of normal and malignant hematopoiesis
    Authors:
    Mariusz Z. Ratajczak, Kamila Bujko, Monika Cymer, Arjun Thapa, Mateusz Adamiak, Janina Ratajczak, Ahmed K. Abdel-Latif, Magda Kucia
    Academic press:
    Leukemia (rok: 2020, tom: 34, strony: 1512-1523), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41375-020-0827-8 - link to the publication

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