Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Influence on inhibition of ribosome biogenesis on oligodendrocyte differentiation and myelination process.

2018/29/B/NZ4/01384

Keywords:

spinal cord injury multiple sclerosis ribosome biogenesis nucleolar stress oligodendrocytes differentiation myelination

Descriptors:

  • NZ4_4:
  • NZ4_12:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anna Filipek 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 068 480 PLN

Project start date (Y-m-d): 2019-01-24

Project end date (Y-m-d): 2024-01-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (17)
  1. CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
    Authors:
    Jurewicz E, Miazga K, Fabczak H, Sławińska U, Filipek A.
    Academic press:
    Neurochem Int. 2020 Sep;138:104757. (rok: 2020, tom: 138, strony: 104757), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2020.104757 - link to the publication
  2. Regulation of S100A10 Gene Expression.
    Authors:
    Głowacka A, Bieganowski P, Jurewicz E, Leśniak W, Wilanowski T, Filipek A.
    Academic press:
    Biomolecules. (rok: 2021, tom: 11(7), strony: 974), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11070974. - link to the publication
  3. Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.
    Authors:
    Bohush A, Góral A, Sierant M, Nawrot B, Leśniak W, Filipek A.
    Academic press:
    Biomolecules (rok: 2021, tom: 11(11), strony: 1675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11111675 - link to the publication
  4. Binding of S100A6 to actin and the actin-tropomyosin complex.
    Authors:
    Jurewicz E, Robaszkiewicz K, Moraczewska J, Filipek A.
    Academic press:
    Sci. Rep. (rok: 2020, tom: 10, strony: 12824), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-69752-y - link to the publication
  5. Ca2+- binding proteins of the S100 family in preeclampsia.
    Authors:
    Jurewicz E, Filipek A.
    Academic press:
    Placenta (rok: 2022, tom: 127, strony: 43-51.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.placenta.2022.07.018. - link to the publication
  6. CacyBP/SIP in the rat spinal cord in norm and after transection - Influence on the phosphorylation state of ERK1/2 and p38 kinases.
    Authors:
    Jurewicz E, Miazga K, Fabczak H, Sławińska U, Filipek A.
    Academic press:
    Neurochem Int. 2020 Sep;138:104757. (rok: 2020, tom: 138, strony: 104757), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2020.104757 - link to the publication
  7. S100A6 and Its Brain Ligands in Neurodegenerative Disorders
    Authors:
    Filipek A, Leśniak W
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21, strony: 3979), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21113979. - link to the publication
  8. RNA-Seq Transcriptome Analysis of Differentiated Human Oligodendrocytic MO3.13 Cells Shows Upregulation of Genes Involved in Myogenesis.
    Authors:
    Głowacka A, Kilańczyk E, Maksymowicz M, Zawadzka M, Leśniak W, Filipek A.
    Academic press:
    International Journal of Molecular Sciences 2022 May 25;23(11):5969. (rok: 2022, tom: 23, strony: 5969), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23115969 - link to the publication
  9. Ca2+- binding proteins of the S100 family in preeclampsia.
    Authors:
    Jurewicz E, Filipek A.
    Academic press:
    Placenta (rok: 2022, tom: 127, strony: 43-51.), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.placenta.2022.07.018. - link to the publication
  10. S100A6 Protein-Expression and Function in Norm and Pathology
    Authors:
    Leśniak W, Filipek A.
    Academic press:
    Int J Mol Sci. (rok: 2023, tom: 24, strony: 1341), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021341 - link to the publication
  11. Regulation of S100A10 Gene Expression.
    Authors:
    Głowacka A, Bieganowski P, Jurewicz E, Leśniak W, Wilanowski T, Filipek A.
    Academic press:
    Biomolecules. (rok: 2021, tom: 11(7), strony: 974), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11070974. - link to the publication
  12. Sgt1 Regulates α-Synuclein Subcellular Localization and Expression of Parkinson's Disease Related Genes, PINK1 and PARK9.
    Authors:
    Bohush A, Góral A, Sierant M, Nawrot B, Leśniak W, Filipek A.
    Academic press:
    Biomolecules (rok: 2021, tom: 11(11), strony: 1675), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11111675 - link to the publication
  13. S100A6 and Its Brain Ligands in Neurodegenerative Disorders
    Authors:
    Filipek A, Leśniak W
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21, strony: 3979), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21113979. - link to the publication
  14. Ca2+-dependent binding of S100A6 to cofilin-1 regulates actin filament polymerization-depolymerization dynamics.
    Authors:
    Robaszkiewicz K, Jurewicz E, Moraczewska J, Filipek A.
    Academic press:
    Cell Calcium (rok: 2021, tom: 99, strony: 102457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceca.2021.102457 - link to the publication
  15. RNA-Seq Transcriptome Analysis of Differentiated Human Oligodendrocytic MO3.13 Cells Shows Upregulation of Genes Involved in Myogenesis.
    Authors:
    Głowacka A, Kilańczyk E, Maksymowicz M, Zawadzka M, Leśniak W, Filipek A.
    Academic press:
    International Journal of Molecular Sciences 2022 May 25;23(11):5969. (rok: 2022, tom: 23, strony: 5969), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23115969 - link to the publication
  16. Ca2+-dependent binding of S100A6 to cofilin-1 regulates actin filament polymerization-depolymerization dynamics.
    Authors:
    Robaszkiewicz K, Jurewicz E, Moraczewska J, Filipek A.
    Academic press:
    Cell Calcium (rok: 2021, tom: 99, strony: 102457), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ceca.2021.102457 - link to the publication
  17. Binding of S100A6 to actin and the actin-tropomyosin complex.
    Authors:
    Jurewicz E, Robaszkiewicz K, Moraczewska J, Filipek A.
    Academic press:
    Sci. Rep. (rok: 2020, tom: 10, strony: 12824), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-69752-y - link to the publication

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