Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Tandem mass spectrometry as a bioanalytical platform for characterization of medicinally promising superparamegnetic nanoparticles

2018/29/B/ST4/00178

Keywords:

tandem mass spectrometry hyphenated techniques superparamagnetic iron oxide nanoparticles

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • ST4_3: Molecular architecture and structure
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Warszawska, Wydział Chemiczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Jarosz 

Number of co-investigators in the project: 6

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 180 500 PLN

Project start date (Y-m-d): 2019-01-24

Project end date (Y-m-d): 2023-01-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Detektor spektrofotometryczny z matrycą diodową do wysokosprawnej chromatografii cieczowej (98 000 PLN)
  2. Sprężarka generatora azotu do tandemowego spektrometru mas z jonizacją poprzez elektrorozpraszanie.
  3. Oprogramowanie do identyfikacji białek po ich cięciu enzymatycznym z modułem sterującym (71 000 PLN)
  4. Systemu oczyszczania wody.
  5. Wirówka z możliwością grzania i chłodzenia komory obrotowej oraz z kompletem kompatybilnych rotorów o zmiennej prędkości wirowania (29 000 PLN)
  6. Automatyczny podajnik próbek do wysokosprawnej chromatografii cieczowej z termostatem (grzanie/chłodzenie), oprogramowaniem i niezbędnym wyposażeniem (97 000 PLN)
  7. Wytrząsarka z grzaniem i chłodzeniem.

Information in the final report

  • Publication in academic press/journals (8)
  • Book publications / chapters in book publications (2)
  1. Toward a deeper and simpler understanding of serum protein-mediated transformations of magnetic nanoparticles by ICP-MS
    Authors:
    O.V. Kuznetsova, M. Jarosz, B. Keppler, A.R. Timerbaev
    Academic press:
    Talanta (rok: 2021, tom: 229, strony: 122287), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.talanta.2021.122287 - link to the publication
  2. Simple Ultraviolet–Visible Spectroscopy-Based Assay for Fast Evaluation of Magnetic Nanoparticle Selectivity Changes After Doping
    Authors:
    Jacek Sikorski, Norbert Obarski, Maciej Trzaskowski, Magdalena Matczuk
    Academic press:
    Applied Spectroscopy (rok: 2021, tom: 75, strony: 1305–1311), Wydawca: SAGE
    Status:
    Published
    DOI:
    10.1177/00037028211028669 - link to the publication
  3. How to effectively prepare a sample for bottom-up proteomic analysis of nanoparticle protein corona? A critical review
    Authors:
    Joanna Kruszewska, Joanna Zajda, Magdalena Matczuk
    Academic press:
    Talanta (rok: 2021, tom: 226, strony: 122153), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.talanta.2021.122153 - link to the publication
  4. Protein‐Mediated Transformations of Superparamagnetic Nanoparticles Evidenced by Single‐Particle Inductively Coupled Plasma Tandem Mass Spectrometry: A Disaggregation Phenomenon
    Authors:
    Jacek Sikorski, Magdalena Matczuk, Agnieszka Kamińska, Joanna Kruszewska, Maciej Trzaskowski, Andrei R. Timerbaev, Maciej Jarosz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1088), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031088 - link to the publication
  5. Red Flags and Adversities on theWay to the Robust CE-ICP-MS/MS Quantitative Monitoring of Self-Synthesized Magnetic Iron Oxide(II, III)-Based Nanoparticle Interactions with Human Serum Proteins
    Authors:
    Jacek Sikorski, Marcin Drozd, Magdalena Matczuk
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 8442), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27238442 - link to the publication
  6. A CE-ICP-MS/MS method for the determination of superparamagnetic iron oxide nanoparticles under simulated physiological conditions
    Authors:
    Joanna Kruszewska, Jacek Sikorski, Jan Samsonowicz-Górski, Magdalena Matczuk
    Academic press:
    Analytical and Bioanalytical Chemistry (rok: 2020, tom: 412, strony: 8145–8153), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-020-02948-3 - link to the publication
  7. High-resolution ICP-MS approach for characterization of magneticnanoparticles for biomedical applications
    Authors:
    Olga V. Kuznetsova, Olga B. Mokhodoeva, Valeria V. Maksimova, Rustam Kh. Dzhenloda, Maciej Jarosz, Valery M. Shkinev, Andrei R. Timerbaev
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2020, tom: 189, strony: 113479), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2020.113479 - link to the publication
  8. How well can we characterize human serum transformations of magnetic nanoparticles?
    Authors:
    Andrei Timerbaev
    Academic press:
    Analyst (rok: 2019, tom: 145, strony: 1103-1109), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9an01920k - link to the publication
  1. Metal-Based Nanomaterials in Biological Matrices
    Authors:
    Joanna Kruszewska, Justyna Wojcieszek, Magdalena Matczuk, Lena Ruzik, Maciej Jarosz
    Book:
    Handbook of Bioanalytics (rok: 2022, tom: 2 (26), strony: 611-626), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
  2. Metalonanomateriały w matrycach biologicznych
    Authors:
    Joanna Kruszewska, Justyna Wojcieszek, Magdalena Matczuk, Lena Ruzik, Maciej Jarosz
    Book:
    Bioanalityka w nauce i życiu (rok: 2020, tom: 1, strony: 401-414), Wydawca: PWN
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy