Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Mechanisms of removal of neutrophil extracellular traps (NETs) from vasculature: an intravital microscopy approach

2018/29/B/NZ6/00713

Keywords:

neutrophils neutrophil extracellular traps sepsis intravital microscopy

Descriptors:

  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Elżbieta Kołaczkowska 

Number of co-investigators in the project: 5

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 869 600 PLN

Project start date (Y-m-d): 2019-01-31

Project end date (Y-m-d): 2023-01-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. "Poczwórna kostka filtrów fluorescencji oraz dodatkowe pojedyncze filtry fluorescencji kompatybilne z Andor spinning-disk DSD2" (85 000 PLN)
  2. "Mikroskop z nieruchomym stolikiem i obiektywami o dużej odległości roboczej do podłączenia do posiadanego modułu konfokalnego spinning-disk DSD2 Andor" (190 000 PLN)
  3. Komora laminarna mikrobiologiczna (15 913 PLN)
  4. Łaźnia wodna (2 253 PLN)
  5. Inkubator CO2 (37 810 PLN)
  6. Komora laminarna II klasy bezpieczeństwa. (29 150 PLN)
  7. Zamrażarka niskotemperaturowa (29 089 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little
    Authors:
    Santocki M, Kolaczkowska E
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 2079), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9092079 - link to the publication
  2. Reduced Neutrophil Extracellular Trap (NET) Formation During Systemic Inflammation in Mice With Menkes Disease and Wilson Disease: Copper Requirement for NET Release
    Authors:
    Iwona Cichon, Weronika Ortmann, Aleksandra Bednarz, Malgorzata Lenartowicz and Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 10, strony: 45308), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.03021 - link to the publication
  3. Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1)
    Authors:
    Gabriela Burczyk, Iwona Cichon , Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 864638), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.864638 - link to the publication
  4. Editorial: Intravital Microscopy Imaging of Leukocytes
    Authors:
    Wong CHY, Jenne CN, Kolaczkowska E.
    Academic press:
    Front Immunol. (rok: 2020, tom: 11, strony: 2137), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.02137 - link to the publication
  5. Patients with COVID-19: in the dark-NETs of neutrophils
    Authors:
    Maximilian Ackermann , Hans-Joachim Anders, Rostyslav Bilyy, Gary L Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J Kaplan, Jason S Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitroulis, Luis E Muñoz, Teluguakula Narasaraju, Elisabeth Naschberger, Indira Neeli , Lai Guan Ng , Marko Z Radic, Konstantinos Ritis, Patrizia Rovere-Querini, Mirco Schapher, Christine Schauer, Hans-Uwe Simon, Jeeshan Singh, Panagiotis Skendros, Konstantin Stark, Michael Stürzl, Johan van der Vlag, Peter Vandenabeele, Ljubomir Vitkov, Maren von Köckritz-Blickwede, Cansu Yanginlar, Shida Yousefi, Alexander Zarbock, Georg Schett, Martin Herrmann
    Academic press:
    Cell Death & Differentiation (rok: 2021, tom: 28, strony: 3125-3139), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41418-021-00805-z - link to the publication

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