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Mechanisms of removal of neutrophil extracellular traps (NETs) from vasculature: an intravital microscopy approach

2018/29/B/NZ6/00713

Keywords

Descriptors

  • NZ6_1: Odporność swoista i nieswoista

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Jagielloński, Wydział Biologii

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Elżbieta Maria Kołaczkowska

Number of co-investigators in the project: 5

Call

OPUS 15 – announced on 2018-03-15

Amount awarded
1 869 600 PLN
Project start date
2019-01-31
Project end date
2023-01-30
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. "Mikroskop z nieruchomym stolikiem i obiektywami o dużej odległości roboczej do podłączenia do posiadanego modułu konfokalnego spinning-disk DSD2 Andor". Cost: 190 000 PLN
  2. "Poczwórna kostka filtrów fluorescencji oraz dodatkowe pojedyncze filtry fluorescencji kompatybilne z Andor spinning-disk DSD2". Cost: 85 000 PLN
  3. Inkubator CO2. Cost: 37 810 PLN
  4. Komora laminarna II klasy bezpieczeństwa.. Cost: 29 150 PLN
  5. Komora laminarna mikrobiologiczna. Cost: 15 913 PLN
  6. Zamrażarka niskotemperaturowa. Cost: 29 089 PLN
  7. Łaźnia wodna. Cost: 2 253 PLN

Information in the final report

Publication in academic press/journals (5)

  1. On Neutrophil Extracellular Trap (NET) Removal: What We Know Thus Far and Why So Little

    Authors:
    Santocki M, Kolaczkowska E
    Academic press:
    Cells (year: 2020, volume: 9, pages: 2079), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9092079 – link to the publication

  2. Patients with COVID-19: in the dark-NETs of neutrophils

    Authors:
    Maximilian Ackermann , Hans-Joachim Anders, Rostyslav Bilyy, Gary L Bowlin, Christoph Daniel, Rebecca De Lorenzo, Mikala Egeblad, Timo Henneck, Andrés Hidalgo, Markus Hoffmann, Bettina Hohberger, Yogendra Kanthi, Mariana J Kaplan, Jason S Knight, Jasmin Knopf, Elzbieta Kolaczkowska, Paul Kubes, Moritz Leppkes, Aparna Mahajan, Angelo A Manfredi, Christian Maueröder, Norma Maugeri, Ioannis Mitroulis, Luis E Muñoz, Teluguakula Narasaraju, Elisabeth Naschberger, Indira Neeli , Lai Guan Ng , Marko Z Radic, Konstantinos Ritis, Patrizia Rovere-Querini, Mirco Schapher, Christine Schauer, Hans-Uwe Simon, Jeeshan Singh, Panagiotis Skendros, Konstantin Stark, Michael Stürzl, Johan van der Vlag, Peter Vandenabeele, Ljubomir Vitkov, Maren von Köckritz-Blickwede, Cansu Yanginlar, Shida Yousefi, Alexander Zarbock, Georg Schett, Martin Herrmann
    Academic press:
    Cell Death & Differentiation (year: 2021, volume: 28, pages: 3125-3139), Publisher: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41418-021-00805-z – link to the publication

  3. Reduced Neutrophil Extracellular Trap (NET) Formation During Systemic Inflammation in Mice With Menkes Disease and Wilson Disease: Copper Requirement for NET Release

    Authors:
    Iwona Cichon, Weronika Ortmann, Aleksandra Bednarz, Malgorzata Lenartowicz and Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (year: 2020, volume: 10, pages: 46039), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2019.03021 – link to the publication

  4. Editorial: Intravital Microscopy Imaging of Leukocytes

    Authors:
    Wong CHY, Jenne CN, Kolaczkowska E.
    Academic press:
    Front Immunol. (year: 2020, volume: 11, pages: 2137), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.02137 – link to the publication

  5. Itaconate Suppresses Formation of Neutrophil Extracellular Traps (NETs): Involvement of Hypoxia-Inducible Factor 1α (Hif-1α) and Heme Oxygenase (HO-1)

    Authors:
    Gabriela Burczyk, Iwona Cichon , Elzbieta Kolaczkowska
    Academic press:
    Frontiers in Immunology (year: 2022, volume: 13, pages: 864638), Publisher: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.864638 – link to the publication

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