Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role of oxidative stress in the pathogenesis of Non-Alcoholic Fatty Liver Disease

2018/29/B/NZ1/00589

Keywords:

oxidative stress Non-Alcoholic Fatty Liver Disease mitochondria

Descriptors:

  • NZ1_2:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Roman Więckowski 

Number of co-investigators in the project: 8

Call: OPUS 15 - announced on 2018-03-15

Amount awarded: 1 896 580 PLN

Project start date (Y-m-d): 2019-01-21

Project end date (Y-m-d): 2024-01-20

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (18)
  • Book publications / chapters in book publications (3)
  1. The mitochondrial permeability transition pore: an evolving concept critical for cell life and death.
    Authors:
    Morciano G, Naumova N, Koprowski P, Valente S, Sardão VA, Potes Y, Rimessi A, Wieckowski MR#, Oliveira PJ.#
    Academic press:
    Biol Rev Camb Philos Soc. (rok: 2021, tom: 96(6), strony: 2489-2521), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/brv.12764. - link to the publication
  2. The Alterations of Mitochondrial Function during NAFLD Progression-An Independent Effect of Mitochondrial ROS Production.
    Authors:
    Simões ICM, Amorim R, Teixeira J, Karkucinska-Wieckowska A, Carvalho A, Pereira SP, Simões RF, Szymanska S, Dąbrowski M, Janikiewicz J, Dobrzyń A, Oliveira PJ, Potes Y, Wieckowski MR.
    Academic press:
    Int J Mol Sci. (rok: 2021, tom: 22(13), strony: 6848), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136848 - link to the publication
  3. Mitochondria-targeted anti-oxidant AntiOxCIN 4 improved liver steatosis in Western Diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and anti-oxidant defense systems
    Authors:
    Amorim R, Simões ICM, Teixeira J, Cagide F, Potes Y, Soares P, Carvalho A, Tavares LC, Benfeito S, Pereira SP, Simões RF, Karkucinska-Wieckowska A, Viegas I, Szymanska S, Dąbrowski M, Janikiewicz J, Cunha-Oliveira T, Dobrzyń A, Jones JG, Borges F, Wieckowski MR$, Oliveira PJ$
    Academic press:
    Redox Biology (rok: 2022, tom: 55 (102400), strony: 45705), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2022.102400 - link to the publication
  4. Exploratory Data Analysis of Cell and Mitochondrial High-Fat, High-Sugar Toxicity on Human HepG2 Cells.
    Authors:
    Amorim R, Simões ICM, Veloso C, Carvalho A, Simões RF, Pereira FB, Thiel T, Normann A, Morais C, Jurado AS, Wieckowski MR, Teixeira J, Oliveira PJ.
    Academic press:
    Nutrients (rok: 2021, tom: 13(5), strony: 1723), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu13051723 - link to the publication
  5. The mystery of mitochondria-ER contact sites in physiology and pathology: A cancer perspective.
    Authors:
    Simoes ICM, Morciano G, Lebiedzinska-Arciszewska M, Aguiari G, Pinton P, Potes Y, Wieckowski MR.
    Academic press:
    Biochim Biophys Acta Mol Basis Dis. (rok: 2020, tom: 1866 (10), strony: 45673), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2020.165834 - link to the publication
  6. Calcium Homeostasis in the Control of Mitophagy
    Authors:
    Perrone M, Patergnani S, Di Mambro T, Palumbo L, Wieckowski MR, Giorgi C, Pinton P.
    Academic press:
    Antioxid Redox Signaling (rok: 2023, tom: 38 (7-9), strony: 581-598), Wydawca: Mary Ann Liebert, Inc.,
    Status:
    Published
    DOI:
    10.1089/ars.2022.0122 - link to the publication
  7. A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease
    Authors:
    Afshan N Malik, Inês C.M. Simões, Hannah S. Rosa, Safa Khan, Agnieszka Karkucinska-Wieckowska and Mariusz R. Wieckowski
    Academic press:
    Cells (rok: 2019, tom: 8 (10), strony: 45671), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8101222 - link to the publication
  8. Antipsychotic drugs counteract autophagy and mitophagy in multiple sclerosis.
    Authors:
    Patergnani S, Bonora M, Ingusci S, Previati M, Marchi S, Zucchini S, Perrone M, Wieckowski MR, Castellazzi M, Pugliatti M, Giorgi C, Simonato M, Pinton P.
    Academic press:
    Proc Natl Acad Sci U S A. (rok: 2021, tom: 118(24), strony: e2020078118), Wydawca: National Academy of Sciences
    Status:
    Published
    DOI:
    10.1073/pnas.2020078118 - link to the publication
  9. Mitochondrial Function and Dysfunction in Dilated Cardiomyopathy.
    Authors:
    Ramaccini D, Montoya-Uribe V, Aan FJ, Modesti L, Potes Y, Wieckowski MR, Krga I, Glibetić M, Pinton P, Giorgi C, Matter ML.
    Academic press:
    Front Cell Dev Biol. (rok: 2021, tom: 8, strony: 624216), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2020.624216 - link to the publication
  10. Cell death as a result of calcium signaling modulation: A cancer-centric prospective.
    Authors:
    Danese A, Leo S, Rimessi A, Wieckowski MR, Fiorica F, Giorgi C, Pinton P.
    Academic press:
    Biochim Biophys Acta Mol Cell Res. (rok: 2021, tom: 1868(8), strony: 119061), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2021.119061 - link to the publication
  11. Physiopathology of the Permeability Transition Pore: Molecular Mechanisms in Human Pathology.
    Authors:
    Bonora M, Patergnani S, Ramaccini D, Morciano G, Pedriali G, Kahsay AE, Bouhamida E, Giorgi C, Wieckowski MR#, Pinton P.#
    Academic press:
    Biomolecules (rok: 2020, tom: 10 (7), strony: 45683), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10070998 - link to the publication
  12. Western Diet Causes Obesity-Induced Nonalcoholic Fatty Liver Disease Development by Differentially Compromising the Autophagic Response.
    Authors:
    Simoes ICM, Karkucinska-Wieckowska A, Janikiewicz J, Szymanska S, Pronicki M, Dobrzyn P, Dabrowski M, Dobrzyn A, Oliveira PJ, Zischka H, Potes Y, Wieckowski MR.
    Academic press:
    Antioxidants (rok: 2020, tom: 9 (10), strony: 45680), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/antiox9100995 - link to the publication
  13. Oxidative stress in metabolic dysfunction-associated steatotic liver disease (MASLD): How does the animal model resemble human disease?
    Authors:
    Patrycja Jakubek, Piotr Kalinowski, Agnieszka Karkucinska-Wieckowska, Aakruti Kaikini, Inês C M Simões, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Michał Grąt, Maciej Pronicki, Magdalena Lebiedzinska-Arciszewska, Marcin Krawczyk, Mariusz R Wieckowski
    Academic press:
    FASEB J. (rok: 2024, tom: 38(3), strony: e23466), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1096/fj.202302447R - link to the publication
  14. Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship.
    Authors:
    Karkucinska-Wieckowska A, Simoes ICM, Kalinowski P, Lebiedzinska-Arciszewska M, Zieniewicz K, Milkiewicz P, Górska-Ponikowska M, Pinton P, Malik AN, Krawczyk M, Oliveira PJ, Wieckowski MR.
    Academic press:
    European Journal of Clinical Investigation (rok: 2021, tom: 52(3), strony: e13622), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/eci.13622 - link to the publication
  15. Mitophagy in Cardiovascular Diseases.
    Authors:
    Morciano G, Patergnani S, Bonora M, Pedriali G, Tarocco A, Bouhamida E, Marchi S, Ancora G, Anania G, Wieckowski MR, Giorgi C, Pinton P.
    Academic press:
    J Clin Med. (rok: 2020, tom: 9 (3), strony: 45683), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm9030892 - link to the publication
  16. Fat and Sugar—A Dangerous Duet. A Comparative Review on Metabolic Remodeling in Rodent Models of Nonalcoholic Fatty Liver Disease
    Authors:
    Simoes ICM, Janikiewicz J, Bauer J, Karkucinska-Wieckowska A, Kalinowski P, Dobrzyń A, Wolski A, Pronicki M, Zieniewicz K, Dobrzyń P, Krawczyk M, Zischka H, Wieckowski MR*#, Potes Y*
    Academic press:
    Nutrients (rok: 2019, tom: 11 (12), strony: 12785), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nu11122871 - link to the publication
  17. MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitis
    Authors:
    Maciej K. Janik, Wiktor Smyk, Beata Kruk, Benedykt Szczepankiewicz, Barbara Górnicka, Magdalena Lebiedzińska-Arciszewska, Yaiza Potes, Inês C. M. Simões, Susanne N. Weber, Frank Lammert, Mariusz R. Więckowski, Piotr Milkiewicz, Marcin Krawczyk
    Academic press:
    Scientific Reports (rok: 2021, tom: 11(1), strony: 24407), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-03521-3 - link to the publication
  18. Aortic Valve Stenosis and Mitochondrial Dysfunctions: Clinical and Molecular Perspectives.
    Authors:
    Pedriali G, Morciano G, Patergnani S, Cimaglia P, Morelli C, Mikus E, Ferrari R, Gasbarro V, Giorgi C, Wieckowski MR, Pinton P.
    Academic press:
    Int J Mol Sci. (rok: 2020, tom: 21 (14), strony: 45681), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21144899. - link to the publication
  1. An Update on Isolation of Functional Mitochondria from Cells for Bioenergetics Studies
    Authors:
    Lebiedzinska-Arciszewska M, Wojtczak L, Wieckowski MR.
    Book:
    Methods Mol Biol. (rok: 2021, tom: 2310, strony: 79-89), Wydawca: SpringerLink
    Status:
    Published
  2. The role of mitochondriaassociated membranes in cellular homeostasis and diseases
    Authors:
    Mariasole Perrone, Natascia Caroccia, Ilaria Genovese, Sonia Missiroli, Lorenzo Modesti, Gaia Pedriali, Bianca Vezzani, Veronica Angela Maria Vitto, Michele Antenori, Magdalena Lebiedzinska-Arciszewska, Mariusz R. Wieckowski, Carlotta Giorgi, Paolo Pinton
    Book:
    International Review of Cell and Molecular Biology (IF=3.788) (rok: 2020, tom: 350, strony: 119 - 196), Wydawca: Elseviere
    Status:
    Published
  3. Update on the Histoenzymatic Methods for Visualization of the Activity of Individual Mitochondrial Respiratory Chain Complexes in the Human Frozen Sections.
    Authors:
    Wieckowski MR, Pronicki M, Karkucinska-Wieckowska A.
    Book:
    Methods Mol Biol. (rok: 2021, tom: 2310, strony: 69-77), Wydawca: SpringerLink
    Status:
    Published

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