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Otrzymywanie i badania biokompozytów na bazie nanoapatytów przeznaczonych do teranostyki

2018/28/T/ST5/00326

Keywords:

Descriptors:

  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_12: Methods of nanomaterials/materials synthesis

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego Polskiej Akademii Nauk

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Sobierajska 

Number of co-investigators in the project: 2

Call: ETIUDA 6 - announced on 2017-12-15

Amount awarded: 110 704 PLN

Project start date (Y-m-d): 2018-10-01

Project end date (Y-m-d): 2019-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  1. Fe3O4 Magnetic Nanoparticles Under Static Magnetic Field Improve Osteogenesis via RUNX-2 and Inhibit Osteoclastogenesis by the Induction of Apoptosis
    Authors:
    Krzysztof Marycz, Paulina Sobierajska, Rafał J Wiglusz, Rafał Idczak, Jean-Marie Nedelec, Andrzej Fal, Katarzyna Kornicka- Garbowska
    Academic press:
    International Journal of Nanomedicine (rok: 2020, tom: 15, strony: 10127-10148), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S256542 - link to the publication
  2. Imatinib-functionalized galactose hydrogels loaded with nanohydroxyapatite as a drug delivery system for osteosarcoma: in vitro studies
    Authors:
    Paulina Sobierajska, Benita Wiatrak, Paulina Jawien, Maciej Janeczek, Katarzyna Wiglusz, Adam Szeląg and Rafal J. Wiglusz
    Academic press:
    ACS Omega (rok: 2023, tom: 8, strony: 17891−17900), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.3c00986 - link to the publication
  3. Influence of Li+ ions on the physicochemical properties of nanocrystalline calcium–strontium hydroxyapatite doped with Eu3+ ions
    Authors:
    Paulina Sobierajska and Rafal J. Wiglusz
    Academic press:
    New Journal of Chemistry (rok: 2019, tom: 43, strony: 14908-14916), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1039/C9NJ03003D - link to the publication
  4. Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration after Mechanical Damage—In Vitro Study
    Authors:
    Benita Wiatrak, Paulina Sobierajska, Marta Szandruk-Bender, Paulina Jawien, Maciej Janeczek, Maciej Dobrzynski, Patrycja Pistor, Adam Szelag and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4454), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094454 - link to the publication
  5. Synergistic Effect of Toceranib and Nanohydroxyapatite as a Drug Delivery Platform—Physicochemical Properties and In Vitro Studies on Mastocytoma Cells
    Authors:
    Paulina Sobierajska, Anna Serwotka-Suszczak, Sara Targonska, Damian Szymanski, Krzysztof Marycz and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1944), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23041944 - link to the publication
  6. Investigation of topography effect on antibacterial properties and biocompatibility of nanohydroxyapatites activated with zinc and copper ions: In vitro study of colloids, hydrogel scaffolds and pellets
    Authors:
    Paulina Sobierajska, Nicole Nowak, Justyna Rewak-Soroczynska, Sara Targonska, Agnieszka Lewińska, Lukasz Grosman, Rafal J. Wiglusz
    Academic press:
    Materials Science & Engineering C (zmiana nazwy na Biomaterials Advances) (rok: 2022, tom: 134, strony: 112547), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2021.112547 - link to the publication
  7. Multifunctionality of Nanosized Calcium Apatite Dual-Doped with Li+/Eu3+ Ions Related to Cell Culture Studies and Cytotoxicity Evaluation In Vitro
    Authors:
    Paulina Sobierajska, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Agata Piecuch, Justyna Rewak-Soroczynska, Agata Dorotkiewicz-Jach, Zuzanna Drulis-Kawa and Rafal J. Wiglusz
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 1388), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11091388 - link to the publication
  8. Nanocrystalline Hydroxyapatite Loaded with Resveratrol in Colloidal Suspension Improves Viability, Metabolic Activity and Mitochondrial Potential in Human Adipose-Derived Mesenchymal Stromal Stem Cells (hASCs)
    Authors:
    Krzysztof Marycz, Agnieszka Smieszek, Justyna Trynda, Paulina Sobierajska, Sara Targonska, Lukasz Grosman and Rafal J. Wiglusz
    Academic press:
    Polymers (rok: 2019, tom: 11, strony: 45314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym11010092 - link to the publication
  9. Preparation and preliminary evaluation of bio-nanocomposites based on hydroxyapatites with antibacterial properties against anaerobic bacteria
    Authors:
    Katarzyna Zawisza, Paulina Sobierajska, Nicole Nowak, Anna Kedziora, Kamila Korzekwa, Blazej Pozniak, Marta Tikhomirov, Julia Miller, Lucyna Mrowczynska, Rafal J. Wiglusz
    Academic press:
    Materials Science & Engineering C (rok: 2020, tom: 106, strony: 110295), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.110295 - link to the publication
  10. Influence of the grain sizes on Stokes and anti-Stokes fluorescence in the Yb3+ and Tb3+ ions co-doped nanocrystalline fluorapatite
    Authors:
    Paulina Sobierajska, Rafal J. Wiglusz
    Academic press:
    Journal of Alloys and Compounds (rok: 2019, tom: 785, strony: 808-818), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jallcom.2019.01.146 - link to the publication
  11. Nanohydroxyapatite-Mediated Imatinib Delivery for Specific Anticancer Applications
    Authors:
    Paulina Sobierajska, Anna Serwotka-Suszczak, Damian Szymanski, Krzysztof Marycz and Rafal J. Wiglusz
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 4602), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204602 - link to the publication
  12. Iron oxides nanoparticles (IOs) exposed to magnetic field promote expression of osteogenic markers in osteoblasts through integrin alpha-3 (INTa-3) activation, inhibits osteoclasts activity and exerts anti-inflammatory action
    Authors:
    K. Marycz, P. Sobierajska, M. Roecken, K. Kornicka‑Garbowska, M. Kępska, R. Idczak, J.‑M. Nedelec and R. J. Wiglusz
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 45315), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12951-020-00590-w - link to the publication
  13. Lithium ions (Li + ) and nanohydroxyapatite (nHAp) doped with Li + enhance expression of late osteogenic markers in adipose-derived stem cells. Potential theranostic application of nHAp doped with Li+ and co-doped with europium (III) and samarium (III) ions
    Authors:
    M. Alicka, P. Sobierajska, K. Kornicka, R.J. Wiglusz, K. Marycz
    Academic press:
    Materials Science & Engineering C (rok: 2019, tom: 99, strony: 1257-1273), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2019.02.073 - link to the publication
  14. New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-L-Galacto-β-D -Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation
    Authors:
    Justyna Rewak-Soroczynska, Paulina Sobierajska, Sara Targonska, Agata Piecuch, Lukasz Grosman, Jaroslaw Rachuna, Slawomir Wasik, Michal Arabski, Rafal Ogorek, and Rafal J. Wiglusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 3112), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063112 - link to the publication

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