Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Synteza, badania spektroskopowe i ocena aktywności biologicznej pochodnych związków pochodzenia naturalnego - monenzyny A i kolchicyny

2018/28/T/ST5/00041

Keywords:

Descriptors:

  • ST5_23:
  • ST5_16:
  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Greta Klejborowska 

Number of co-investigators in the project: 2

Call: ETIUDA 6 - announced on 2017-12-15

Amount awarded: 115 676 PLN

Project start date (Y-m-d): 2018-10-01

Project end date (Y-m-d): 2019-09-30

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Antiproliferative activity of ester derivatives of monensin A at the C‐1 and C‐26 positions
    Authors:
    Greta Klejborowska, Marta Jędrzejczyk, Natalia Stępczyńska, Ewa Maj, Joanna Wietrzyk, Adam Huczyński
    Academic press:
    Chemical Biology & Drug Design (rok: 2019, tom: 94, strony: 1859–1864), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.13581 - link to the publication
  2. Synthesis, antiproliferative activity, and molecular docking studies of 4‐chlorothiocolchicine analogues
    Authors:
    Greta Klejborowska, Mahshad Moshari, Ewa Maj, Urszula Majcher, Jordane Preto, Joanna Wietrzyk, Adam Huczyński
    Academic press:
    Chemical Biology & Drug Design (rok: 2020, tom: 95, strony: 182–191), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.13618 - link to the publication
  3. Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives
    Authors:
    Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski, Timothy C. Chambers, Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2021, tom: 32, strony: 116014), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2021.116014 - link to the publication
  4. Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents
    Authors:
    Greta Klejborowska, Alicja Urbaniak, Jordane Preto, Ewa Maj, Mahshad Moshari, Joanna Wietrzyk, Jack A. Tuszynski, Thimothy C. Chambers, Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2019, tom: 27, strony: 115144), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2019.115144 - link to the publication
  5. In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand
    Authors:
    Lorenzo Pallante, Antonio Rocca, Greta Klejborowska, Adam Huczynski, Gianvito Grasso, Jack A. Tuszynski, Marco A. Deriu
    Academic press:
    Frontiers in Chemistry (rok: 2020, tom: 8, strony: 108), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fchem.2020.00108 - link to the publication
  6. Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
    Authors:
    Urszula Majcher, Greta Klejborowska, Magdalena Kaik, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski, Adam Huczyńskiczy ´nski
    Academic press:
    Cells (rok: 2018, tom: 7, strony: 216), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells7110216 - link to the publication
  7. Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents
    Authors:
    Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Jordane Preto, Mahshad Moshari, Joanna Wietrzyk, Jack A. Tuszynski, Timothy C. Chambers, Adam Huczyński
    Academic press:
    Bioorganic Chemistry (rok: 2020, tom: 97, strony: 103664), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103664 - link to the publication

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