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Synteza, badania spektroskopowe i ocena aktywności biologicznej pochodnych związków pochodzenia naturalnego - monenzyny A i kolchicyny

2018/28/T/ST5/00041

Descriptors

  • ST5_23: Chemia organiczna
  • ST5_16: Chemia biologiczna
  • ST5_11: Synteza biomateriałów

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

Greta Klejborowska

Number of co-investigators in the project: 2

Call

ETIUDA 6 – announced on 2017-12-15

Amount awarded
115 676 PLN
Project start date
2018-10-01
Project end date
2019-09-30
Project duration
12 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (7)

  1. Synthesis, anticancer activity and molecular docking studies of N-deacetylthiocolchicine and 4-iodo-N-deacetylthiocolchicine derivatives

    Authors:
    Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski, Timothy C. Chambers, Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry (year: 2021, volume: 32, pages: 116014), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2021.116014 – link to the publication

  2. In silico Investigations of the Mode of Action of Novel Colchicine Derivatives Targeting β-Tubulin Isotypes: A Search for a Selective and Specific β-III Tubulin Ligand

    Authors:
    Lorenzo Pallante, Antonio Rocca, Greta Klejborowska, Adam Huczynski, Gianvito Grasso, Jack A. Tuszynski, Marco A. Deriu
    Academic press:
    Frontiers in Chemistry (year: 2020, volume: 8, pages: 108), Publisher: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fchem.2020.00108 – link to the publication

  3. Synthesis, biological evaluation and molecular docking studies of new amides of 4-bromothiocolchicine as anticancer agents

    Authors:
    Greta Klejborowska, Alicja Urbaniak, Jordane Preto, Ewa Maj, Mahshad Moshari, Joanna Wietrzyk, Jack A. Tuszynski, Thimothy C. Chambers, Adam Huczyński
    Academic press:
    Bioorganic & Medicinal Chemistry (year: 2019, volume: 27, pages: 115144), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2019.115144 – link to the publication

  4. Synthesis, biological evaluation and molecular docking studies of new amides of 4-chlorothiocolchicine as anticancer agents

    Authors:
    Greta Klejborowska, Alicja Urbaniak, Ewa Maj, Jordane Preto, Mahshad Moshari, Joanna Wietrzyk, Jack A. Tuszynski, Timothy C. Chambers, Adam Huczyński
    Academic press:
    Bioorganic Chemistry (year: 2020, volume: 97, pages: 103664), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2020.103664 – link to the publication

  5. Antiproliferative activity of ester derivatives of monensin A at the C‐1 and C‐26 positions

    Authors:
    Greta Klejborowska, Marta Jędrzejczyk, Natalia Stępczyńska, Ewa Maj, Joanna Wietrzyk, Adam Huczyński
    Academic press:
    Chemical Biology & Drug Design (year: 2019, volume: 94, pages: 1859–1864), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.13581 – link to the publication

  6. Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents

    Authors:
    Urszula Majcher, Greta Klejborowska, Magdalena Kaik, Ewa Maj, Joanna Wietrzyk, Mahshad Moshari, Jordane Preto, Jack A. Tuszynski, Adam Huczyńskiczy ´nski
    Academic press:
    Cells (year: 2018, volume: 7, pages: 216), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells7110216 – link to the publication

  7. Synthesis, antiproliferative activity, and molecular docking studies of 4‐chlorothiocolchicine analogues

    Authors:
    Greta Klejborowska, Mahshad Moshari, Ewa Maj, Urszula Majcher, Jordane Preto, Joanna Wietrzyk, Adam Huczyński
    Academic press:
    Chemical Biology & Drug Design (year: 2020, volume: 95, pages: 182–191), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1111/cbdd.13618 – link to the publication

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