Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Epigenetic mechanisms determining the defective innate immunity responses in malignant gliomas

2017/27/B/NZ3/01605

Keywords:

epigenetics chromatin immunoprecipitation mapping open chromatin gene regulation antitumor responses immunosuppression

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_5: Molecular neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bożena Kamińska-Kaczmarek 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 900 200 PLN

Project start date (Y-m-d): 2018-07-31

Project end date (Y-m-d): 2022-01-30

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Transblot Turbo (12 181 PLN)
  2. komputer stacjonarny (10 000 PLN)
  3. 8-stanowiskowy dysocjator komórek z podgrzewaniem (135 000 PLN)
  4. Wytrząsarka (4 463 PLN)
  5. mikrowirówka (1 794 PLN)
  6. Urządzenie do przygotowywania bibliotek do sekwencjonowania z pojedynczych komórek 10X Genomics.
  7. Wirówka z chłodzeniem (22 750 PLN)
  8. Automatyzowane, oparte o fluorescencję urządzenie do sortowania komórek (minisorter) (500 000 PLN)
  9. Mikroskop odwrócony z kontrastem fazowym (150 000 PLN)
  10. Autoklaw (6 520 PLN)
  11. Jednostronny regał na klatki indywidualnie wentylowane.
  12. Komora laminarna.
  13. kontroler temperatury (4 973 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Dissecting the Immune Microenvironment of Malignant Gliomas with Single-Cell Omic Reveals New Treatment Opportunities
    Authors:
    Kaminska B, Lenkiewicz A,
    Academic press:
    Onco Therapeutics (rok: 2021, tom: 8 (2), strony: 1028), Wydawca: Begell House
    Status:
    Published
    DOI:
    10.1615/ForumImmunDisTher.2021041708 - link to the publication
  2. Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
    Authors:
    Natalia Ochocka, Pawel Segit, Kacper Adam Walentynowicz, Kamil Wojnicki, Salwador Cyranowski, Julian Swatler, Jakub Mieczkowski & Bozena Kaminska
    Academic press:
    Nature Communications (rok: 2021, tom: 12; 1151, strony: 45305), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-021-21407-w - link to the publication
  3. Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics.
    Authors:
    Ochocka N, Kaminska B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(6), strony: 3027), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063027 - link to the publication
  4. Single-Cell Omics in Dissecting Immune Microenvironment of Malignant Gliomas-Challenges and Perspectives
    Authors:
    Bozena Kaminska, Natalia Ochocka, Pawel Segit
    Academic press:
    CELLS (rok: 2021, tom: 10(9), strony: 2264), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092264 - link to the publication

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