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Epigenetic mechanisms determining the defective innate immunity responses in malignant gliomas

2017/27/B/NZ3/01605

Keywords

Descriptors

  • NZ1_1: Biologia molekularna
  • NZ3_5: Neurobiologia molekularna
  • NZ3_7: Przekaźnictwo sygnału

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Bożena Kamińska-Kaczmarek

Number of co-investigators in the project: 5

Call

OPUS 14 – announced on 2017-09-15

Amount awarded
1 900 200 PLN
Project start date
2018-07-31
Project end date
2022-01-30
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. 8-stanowiskowy dysocjator komórek z podgrzewaniem. Cost: 135 000 PLN
  2. Autoklaw. Cost: 6 520 PLN
  3. Automatyzowane, oparte o fluorescencję urządzenie do sortowania komórek (minisorter). Cost: 500 000 PLN
  4. Jednostronny regał na klatki indywidualnie wentylowane.
  5. Komora laminarna.
  6. Mikroskop odwrócony z kontrastem fazowym. Cost: 150 000 PLN
  7. Transblot Turbo. Cost: 12 181 PLN
  8. Urządzenie do przygotowywania bibliotek do sekwencjonowania z pojedynczych komórek 10X Genomics.
  9. Wirówka z chłodzeniem. Cost: 22 750 PLN
  10. Wytrząsarka. Cost: 4 463 PLN
  11. komputer stacjonarny. Cost: 10 000 PLN
  12. kontroler temperatury. Cost: 4 973 PLN
  13. mikrowirówka. Cost: 1 794 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Single-Cell Omics in Dissecting Immune Microenvironment of Malignant Gliomas-Challenges and Perspectives

    Authors:
    Bozena Kaminska, Natalia Ochocka, Pawel Segit
    Academic press:
    CELLS (year: 2021, volume: 10(9), pages: 2264), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092264 – link to the publication

  2. Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

    Authors:
    Natalia Ochocka, Pawel Segit, Kacper Adam Walentynowicz, Kamil Wojnicki, Salwador Cyranowski, Julian Swatler, Jakub Mieczkowski & Bozena Kaminska
    Academic press:
    Nature Communications (year: 2021, volume: 12; 1151, pages: 46036), Publisher: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-021-21407-w – link to the publication

  3. Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics.

    Authors:
    Ochocka N, Kaminska B.
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22(6), pages: 3027), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063027 – link to the publication

  4. Dissecting the Immune Microenvironment of Malignant Gliomas with Single-Cell Omic Reveals New Treatment Opportunities

    Authors:
    Kaminska B, Lenkiewicz A,
    Academic press:
    Onco Therapeutics (year: 2021, volume: 8 (2), pages: 1028), Publisher: Begell House
    Status:
    Published
    DOI:
    10.1615/ForumImmunDisTher.2021041708 – link to the publication

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