Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Epigenetic mechanisms determining the defective innate immunity responses in malignant gliomas

2017/27/B/NZ3/01605

Keywords:

epigenetics chromatin immunoprecipitation mapping open chromatin gene regulation antitumor responses immunosuppression

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_5: Molecular neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bożena Kamińska-Kaczmarek 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 900 200 PLN

Project start date (Y-m-d): 2018-07-31

Project end date (Y-m-d): 2022-01-30

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Autoklaw (6 520 PLN)
  2. Mikroskop odwrócony z kontrastem fazowym (150 000 PLN)
  3. Jednostronny regał na klatki indywidualnie wentylowane.
  4. Wirówka z chłodzeniem (22 750 PLN)
  5. mikrowirówka (1 794 PLN)
  6. Wytrząsarka (4 463 PLN)
  7. 8-stanowiskowy dysocjator komórek z podgrzewaniem (135 000 PLN)
  8. Automatyzowane, oparte o fluorescencję urządzenie do sortowania komórek (minisorter) (500 000 PLN)
  9. Transblot Turbo (12 181 PLN)
  10. Komora laminarna.
  11. Urządzenie do przygotowywania bibliotek do sekwencjonowania z pojedynczych komórek 10X Genomics.
  12. komputer stacjonarny (10 000 PLN)
  13. kontroler temperatury (4 973 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Dissecting the Immune Microenvironment of Malignant Gliomas with Single-Cell Omic Reveals New Treatment Opportunities
    Authors:
    Kaminska B, Lenkiewicz A,
    Academic press:
    Onco Therapeutics (rok: 2021, tom: 8 (2), strony: 1028), Wydawca: Begell House
    Status:
    Published
    DOI:
    10.1615/ForumImmunDisTher.2021041708 - link to the publication
  2. Microglia Diversity in Healthy and Diseased Brain: Insights from Single-Cell Omics.
    Authors:
    Ochocka N, Kaminska B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(6), strony: 3027), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22063027 - link to the publication
  3. Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
    Authors:
    Natalia Ochocka, Pawel Segit, Kacper Adam Walentynowicz, Kamil Wojnicki, Salwador Cyranowski, Julian Swatler, Jakub Mieczkowski & Bozena Kaminska
    Academic press:
    Nature Communications (rok: 2021, tom: 12; 1151, strony: 45305), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-021-21407-w - link to the publication
  4. Single-Cell Omics in Dissecting Immune Microenvironment of Malignant Gliomas-Challenges and Perspectives
    Authors:
    Bozena Kaminska, Natalia Ochocka, Pawel Segit
    Academic press:
    CELLS (rok: 2021, tom: 10(9), strony: 2264), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092264 - link to the publication

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