Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Co-delivery drug systems based on ionic graft polymers carrying pharmaceutical anions with antibacterial activities for combined therapy

2017/27/B/ST5/00960

Keywords:

drug delivery systems antibacterial polymeric carriers anion exchange

Descriptors:

  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_21:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Śląska, Wydział Chemiczny

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dorota Neugebauer 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 799 350 PLN

Project start date (Y-m-d): 2018-09-17

Project end date (Y-m-d): 2022-09-16

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. goniometr/tensjometr do pomiaru statycznego kąta zwilżania (70 500 PLN)
  2. aparat do chromatografii wykluczania w układzie polarnym (165 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (2)
  1. Ionic polymethacrylate based delivery systems: effect of carrier topology and drug loading
    Authors:
    D. Neugebauer, A. Mielańczyk, R. Bielas, J. Odrobińska, M. Kupczak, K. Niesyto
    Academic press:
    Pharmaceutics (rok: 2019, tom: 11, strony: 337), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics11070337 - link to the publication
  2. Synthesis and Characterization of Ionic Graft Copolymers: Introduction and In Vitro Release of Antibacterial Drug by Anion Exchange
    Authors:
    Katarzyna Niesyto, Dorota Neugebauer
    Academic press:
    Polymers (rok: 2020, tom: 12, strony: 2159), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12092159 - link to the publication
  3. Choline based polymethacrylate matrix with pharmaceutical cations as co-delivery system for antibacterial and anti-inflammatory combined therapy
    Authors:
    Rafał Bielas, Agnieszka Siewniak, Magdalena Skonieczna, Małgorzata Adamiec, Łukasz Mielańczyk, Dorota Neugebauer
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 285, strony: 114-122), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2019.04.082 - link to the publication
  4. Choline supported poly(ionic liquid) graft copolymers as novel delivery systems of anionic pharmaceuticals for anti-inflammatory and anti-coagulant therapy
    Authors:
    R. Bielas, A. Mielańczyk, M. Skonieczna, Ł. Mielańczyk, D. Neugebauer
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 14410), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-019-50896-5 - link to the publication
  5. Pharmaceutical functionalization of monomeric ionic liquid for the preparation of ionic graft polymer conjugates
    Authors:
    Mazur Aleksy, Niesyto Katarzyna, Neugebauer Dorota
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 14731), Wydawca: mpi
    Status:
    Published
    DOI:
    10.3390/ijms232314731 - link to the publication
  6. Toxicity evaluation of choline ionic liquid-based nanocarriers of pharmaceutical agents for lung treatment
    Authors:
    Katarzyna Niesyto, Magdalena Skonieczna, Małgorzata Adamiec-Organiściok, Dorota Neugebauer
    Academic press:
    Journal of Biomedical Materials Research Part B - Applied Biomaterials , Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. Biological In Vitro Evaluation of PIL Graft Conjugates: Cytotoxicity Characteristics
    Authors:
    Katarzyna Niesyto, Wiktoria Łyżniak, Magdalena Skonieczna and Dorota Neugebauer
    Academic press:
    International Journals of Molecular Sciences (rok: 2021, tom: 22, strony: 7741), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  8. Dual-Drug Delivery via the Self-Assembled Conjugates of Choline-Functionalized Graft Copolymers
    Authors:
    Katarzyna Niesyto , Aleksy Mazur and Dorota Neugebauer
    Academic press:
    Materials (rok: 2022, tom: 15, strony: 4457), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  9. Linear Copolymers Based on Choline Ionic Liquid Carrying Anti-Tuberculosis Drugs: Influence of Anion Type on Physicochemical Properties and Drug Release
    Authors:
    Katarzyna Niesyto, Dorota Neugebauer
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 284), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22010284 - link to the publication
  1. Inżynieria makromolekularna - projektowanie struktur szczepionych
    Authors:
    D. Neugebauer
    Conference:
    Modyfikacja polimerów MODPOL (rok: 2019, ), Wydawca: Tempo s.c.
    Data:
    konferencja 15-18.09.2019
    Status:
    Published
  2. Polimerowe ciecze jonowe jako nośniki leków przeciwgruźliczych
    Authors:
    D. Neugebauer i K. Niesyto
    Conference:
    Modyfikacja polimerów MODPOL (rok: 2021, ), Wydawca: Tempo s.c.
    Data:
    konferencja 06-09.09.2021
    Status:
    Published

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