Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Can stabilization of sulfur-centered radical cations affect protein functionality? From model compounds to real biological systems.

2017/27/B/ST4/00375

Keywords:

benzophenone methionine proteins sulfur radials photooxidation

Descriptors:

  • ST4_17: Chemical reactions: mechanisms, thermodynamics, kinetics
  • ST4_14: Catalysis
  • ST4_16: Ionic liquids

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bronisław Marciniak 

Number of co-investigators in the project: 7

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 179 400 PLN

Project start date (Y-m-d): 2018-06-12

Project end date (Y-m-d): 2023-01-11

Project duration:: 55 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Akcesoria uzupełniające do spektrofluorymetru.
  2. Detektor fluorescencyjny do UHPLC (90 000 PLN)
  3. Temperature-Controlled Cuvette Holder for laser spectroscopy (Uchwyt do lasera) (41 998 PLN)
  4. Waga analityczna (7 167 PLN)
  5. Wirówka laboratoryjna MPW.
  6. Disperser.
  7. PH Metr F20 Fiveeasy standard kit i Wytrząsarka PS-3D mini.
  8. Suszarka z konwekcją wymuszoną (Inkubator do próbek białkowych i układów modelowych z wymuszoną konwersją).
  9. System oczyszczania wody (28 000 PLN)
  10. Kriostat do pomiarów spektroskopowych (110 000 PLN)
  11. Laptop HP Probook.
  12. Mieszadło magnetyczne (3 156 PLN)
  13. Waga analityczna AS.
  14. Licencja Lab View oraz elektroniczne moduły komunikacyjne (40 000 PLN)
  15. Zestaw do naświetlań.
  16. pH-metr (3 662 PLN)
  17. Demineralizator HLP SMART.
  18. Łaźnia ultradźwiękowa (5 781 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. Unexpected reaction pathway of the alpha-aminoalkyl radical derived from one-electron oxidation of S-alkyl-glutathiones
    Authors:
    T. Pedzinski, K. Bobrowski, B. Marciniak, P. Filipiak
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 877-890), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/moleules25040877 - link to the publication
  2. Evaluation of Hydroxyl Radical Reactivity by Thioether Group Proximity in Model Peptide Backbone: Methionine versus S-Methyl-Cysteine
    Authors:
    Ch. Chatgilaloglu, M. Grzelak, K. Skotnicki, P. Filipiak, F. Kazmierczak, G.L. Hug, K. Bobrowski, B. Marciniak
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 6550 - 6568), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23126550 - link to the publication
  3. Photo- and Radiation-Induced One-Electron Oxidation of Methionine in Various Structural Environments Studied by Time-Resolved Techniques
    Authors:
    Bronisław Marciniak, Krzysztof Bobrowski
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 1028 - 1062), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27031028 - link to the publication
  4. Radiation- and Photoinduced Oxidation Pathways of Methionine Located in Model of Protein Interior Under Anoxic Conditions
    Authors:
    Tomasz Pedzinski, Katarzyna. Grzyb, Konrad Skotnicki, Piotr Filipiak, Krzysztof Bobrowski, Chrystosomus Chatgilialoglu, Bronislaw Marciniak
    Academic press:
    Int. J. Mol. Sci. (rok: 2021, tom: 22, strony: 4773 - 4789), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094773 - link to the publication
  5. Does the presence of ground state complex between a PR-10 protein and a sensitizer affect the mechanism of sensitized photo-oxidation?
    Authors:
    Marta Ignasiak-Kciuk, Karolina Nowicka-Bauer, Marta Grzechowiak, Tina Ravensborg, Kamil Frąckowiak, Ole N. Jensen, Mariusz Jaskólski, Bronisław Marciniak
    Academic press:
    Free Radicals in Biology and Medicine (rok: 2023, tom: 198, strony: 27-43), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1039/FT9918701509 - link to the publication
  6. N-terminal Decarboxylation as a Probe for Interaction Between Terminal Amino Acid Residues. The case of γ-Glu-(Pro)n-Met Peptides
    Authors:
    P. Filipiak, K. Bobrowski, G. L. Hug, C. Schöneich, B. Marciniak
    Academic press:
    J. Phys. Chem. B (rok: 2020, tom: 124, strony: 8082-8098), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c04371 - link to the publication
  7. Sensitized photo-oxidation of plant cytokinin-specific binding protein - Do the surroundings of the thioether influence the oxidation reaction? From primary intermediates to stable products
    Authors:
    Marta Ignasiak, Karolina Nowicka-Bauer, Marta Grzechowiak, Michał Sikorski, Bachuki Shashikadze, Mariusz Jaskolski, Bronisław Marciniak
    Academic press:
    Free Radical Biol. Med. (rok: 2021, tom: xxx, strony: 45301), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2021.02.004 - link to the publication
  8. The early events of photosensitized oxidation of sulfur-containing amino acids studied by laser flash photolysis and mass spectrometry
    Authors:
    T. Pedzinski, K. Grzyb, F. Kazmierczak, R. Frański, P. Filipiak, B. Marciniak
    Academic press:
    J. Phys. Chem. B (rok: 2020, tom: 124, strony: 7564-7573), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.0c06008 - link to the publication
  9. Unexpected light emission from tyrosyl radical as probe for the tyrosine oxidation
    Authors:
    M. Ignasiak, K. Frackowiak , T. Pedzinski , M. J. Davies, B. Marciniak
    Academic press:
    Free Radical Biology and Medicine (rok: 2020, tom: 153, strony: 45642), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2020.03.022 - link to the publication

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