Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Dysfunction of pancreatic isles in type 2 diabetes – role of fatty acids and epigenetic mechanisms in maintenance of pancreatic α- and β-cells identity

2017/27/N/NZ3/01987

Keywords:

DNA methylation pancreatic islets insulin glucagon type 2 diabetes epigenetics

Descriptors:

  • NZ3_2: Cell physiology
  • NZ3_1: Cell biology
  • NZ3_14: Other related subjects

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Aneta Dobosz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 139 200 PLN

Project start date (Y-m-d): 2018-07-26

Project end date (Y-m-d): 2021-07-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (7)
  • Book publications / chapters in book publications (1)
  1. Spotlight on epigenetics as a missing link between obesity and type 2 diabetes
    Authors:
    Aneta M. Dobosz, Anna Dziewulska, Agnieszka Dobrzyń
    Academic press:
    Postępy Biochemii (rok: 2018, tom: 64, strony: 157-165), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2018_126 - link to the publication
  2. Stearoyl-CoA Desaturase 1 Activity Determines the Maintenance of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Anna M. Borkowska, Anna Dziewulska, Ewelina Lipiec, Pawel Dobrzyn, Wojciech M. Kwiatek, Agnieszka Dobrzyn
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 6844), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186844 - link to the publication
  1. Islets therapeutic checkpoint: Inhibition of stearoyl‐CoA desaturase impairs lipid droplet morphology and metabolism during palmitotoxicity of pancreatic β‐cells
    Authors:
    Justyna Janikiewicz, Aneta Maria Dobosz, Katarzyna Majzner, Tytus Bernaś, Agnieszka Dobrzyń
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: WILEY
    Data:
    konferencja 4-7 kwiecień 2020
    Status:
    Published
    DOI:
    link to the publication
  2. Metformin does not prevent lipid-derived loss of pancreatic β-cell identity due to downregulation of stearoyl Co-A desaturase 1
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Agnieszka Dobrzyn
    Conference:
    International Conference on the Bioscience of Lipids 2021 (rok: 2021, ), Wydawca: Organizatorzy konferencji
    Data:
    konferencja 44540
    Status:
    Published
  3. Role of stearoyl-CoA desaturase 1 in epigenetic control of pancreatic β-cells functional identity
    Authors:
    Aneta M. Dobosz, Agnieszka Dobrzyn
    Conference:
    3rd PhD Student Conference (rok: 2018, ), Wydawca: Organizatorzy konferencji
    Data:
    konferencja 43384
    Status:
    Published
    DOI:
    link to the publication
  4. Stearoyl‐CoA desaturase 1 determines pancreatic β‐cell fate through regulation of DNA methylation pattern
    Authors:
    Aneta Maria Dobosz, Justyna Janikiewicz, Anna Maria Borkowska, Wojciech Maria Kwiatek, Agnieszka Dobrzyn
    Conference:
    Experimental Biology 2020 (rok: 2020, ), Wydawca: WILEY
    Data:
    konferencja 4-7 kwiecień 2020
    Status:
    Published
    DOI:
    link to the publication
  5. Lipid-derived loss of pancreatic b-cell identity – the role of stearoyl Co-A desaturase 1
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Anna Dziewulska, Agnieszka Dobrzyn
    Conference:
    The 44th FEBS Congress (rok: 2019, ), Wydawca: Wiley
    Data:
    konferencja 43652
    Status:
    Published
  6. Metformin exerts dual effect on pancreatic β-cells through downregulation of stearoyl Co-A desaturase 1
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Agnieszka Dobrzyń
    Conference:
    The 45th FEBS Congress "Molecules of Life: Towards New Horizons" (rok: 2021, ), Wydawca: WILEY
    Data:
    konferencja 3-8 lipiec
    Status:
    Published
  7. Stearoyl-CoA desaturase 1 - a novel player in regulation of pancreatic β-cell identity
    Authors:
    Aneta M. Dobosz, Justyna Janikiewicz, Anna Dziewulska, Katarzyna Kolczynska, Agnieszka Dobrzyn
    Conference:
    60th International Conference on the Bioscience of Lipids (rok: 2019, ), Wydawca: Organizatorzy konferencji
    Data:
    konferencja 43633
    Status:
    Published
  1. Sphingolipid mediators of cell signaling and metabolism
    Authors:
    Agnieszka Dobrzyn, Justyna Janikiewicz, Zuzanna Tracz-Gaszewska, Anna Filip, Aneta M. Dobosz, Ewelina Krogulec, Pawel Dobrzyn
    Book:
    Lipid Signaling and Metabolism (rok: 2020, tom: 1, strony: 385-411), Wydawca: Elsevier, Academic Press
    Status:
    Published

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