Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Polymorphisms in otolin-1 genes in human and zebrafish - influence on function of the C1q-like domain in biomineralization of carbonate receptors of gravity

2017/27/N/NZ1/01319

Keywords:

otolin-1 calcium binding proteins biomineralization fluorescence circular dichroism collagen differential scanning fluorimetry analytical ultracentrifugation calcium carbonate structural change

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Rafał Hołubowicz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 179 990 PLN

Project start date (Y-m-d): 2018-07-24

Project end date (Y-m-d): 2022-07-23

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Wirówka z chłodzeniem (29 000 PLN)
  2. Wytrząsarka Vortex BenchMixer z adapterem na jedną mikropłytkę.

Information in the final report

  • Publication in academic press/journals (2)
  1. Molecular mechanism of calcium induced trimerization of C1q-like domain of otolin-1 from human and zebrafish
    Authors:
    Rafał Hołubowicz, Andrzej Ożyhar, Piotr Dobryszycki
    Academic press:
    Scientific Reports (rok: 2021, tom: 11, strony: 12778), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-92129-8 - link to the publication
  2. Natural Mutations Affect Structure and Function of gC1q Domain of Otolin-1
    Authors:
    Rafał Hołubowicz, Andrzej Ożyhar, Piotr Dobryszycki
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(16), strony: 9085), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22169085 - link to the publication

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