Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New derivatives of clopidogrel - enantioselective biosynthesis and antiplatelet activity in vitro

2017/27/N/NZ7/02424

Keywords:

clopidogrel blood plattelets enzyme farmacodynamic profile drug-receptor affinity aggregometry

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Adam Sikora 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 202 500 PLN

Project start date (Y-m-d): 2018-09-03

Project end date (Y-m-d): 2021-09-02

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Urządzenie chłodzące do skaningowego kalorymetru różnicowego wraz z oprzyrządowaniem.
  2. Generator azotu do spektrometru mas (45 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. The utilization of two-phase catalytic system in enantioselective biotransformation of racemic atenolol
    Authors:
    Joanna Chałupka, Adam Sikora, Michał Piotr Marszałł
    Academic press:
    Catalysts (rok: 2021, tom: 12, strony: 45303), Wydawca: 4,501
    Status:
    Published
    DOI:
    10.3390/catal12091068 - link to the publication
  2. The utilization of ionic liquids in enantioseletive biotransformation of racemic clopidogrel
    Authors:
    Joanna Chałupka, Adam Sikora, Michał Piotr Marszałł
    Academic press:
    International Journal of Molecular Sciences , Wydawca: MDPI
    Status:
    Submitted
  3. Overview : enzyme-catalyzed enantioselective biotransformations of chiral active compounds used in hypertension treatment
    Authors:
    Chałupka Joanna, Sikora Adam, Kozicka Aleksandra, Marszałł Michał Piotr.
    Academic press:
    Current Organic Chemistry (rok: 2020, tom: 24, strony: 2782-2791), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1385272824999201020204256 - link to the publication
  4. The Application of Two-Phase Catalytic System in Enantioselective Separation of Racemic (R,S)-1-Phenylethanol
    Authors:
    Joanna Chałupka, Jacek Dulęba, Adam Sikora, Tomasz Siódmiak, Michał Marszałł
    Academic press:
    Catalysts (rok: 2023, tom: 13, strony: 45305), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal13020292 - link to the publication
  5. The use of ion liquids as a trojan horse strategy in enzyme-catalyzed biotransformation of (R,S)-atenolol.
    Authors:
    Sikora Adam, Chałupka Joanna, Marszałł Michał Piotr.
    Academic press:
    Catalysts (rok: 2020, tom: 10, strony: 45302), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/catal10070787 - link to the publication
  1. Zastosowanie cieczy jonowych w enancjoselektywnej biotransformacji (R,s)-klopidogrelu
    Authors:
    Joanna Chałupka, Adam Sikora, Michał Piotr Marszałł
    Conference:
    Analiza Zagadnienia, Analiza Wyników (rok: 2022, ), Wydawca: Creativetime
    Data:
    konferencja 44684
    Status:
    Published
  2. Ciecze jonowe jako środowisko reakcji dla rozdziału kinetycznego (R,S)-klopidogrelu
    Authors:
    Joanna Chałupka, Adam Sikora, Michał Piotr Marszałł
    Conference:
    XIV Ogólnokrajowa Konferencja Naukowa - jesień 2021 (rok: 2021, ), Wydawca: Młodzi Naukowcy
    Data:
    konferencja 44526
    Status:
    Published