Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Investigation of the effect of thiol group and urea bond on the peptidomimetics' affinity to receptors associated with angiogenesis and enzymatic stability

2017/27/N/NZ7/02473

Keywords:

angiogenesis neuropilin-1 VEGF-A165/NRP-1 complex inhibitors peptidomimetics peptide/urea hybrids

Descriptors:

  • ST5_16:
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_23:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Puszko 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 139 300 PLN

Project start date (Y-m-d): 2018-08-10

Project end date (Y-m-d): 2020-08-09

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Does Cysteine Rule (CysR) complete the CendR principle? Increase in affnity of peptide ligands for NRP-1 through the presence of N-terminal cysteine
    Authors:
    Puszko A. K., Sosnowski P., Raynaud F., Hermine O., Hopfgartner G., Lepelletier Y., Misicka A.
    Academic press:
    Biomolecules (rok: 2020, tom: 10, strony: 448), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom10030448 - link to the publication
  2. Urea moiety as amide bond mimetic in peptide-like inhibitors of VEGF-A165/NRP-1 complex
    Authors:
    Puszko A. K., Sosnowski P., Pułka-Ziach K., Hermine O., Hopfgartner G., Lepelletier Y., Misicka A.
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2019, tom: 29, strony: 2493-2497), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2019.07.016 - link to the publication

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