Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Multi-objective optimization of the genetic code

2017/27/N/NZ2/00403

Keywords:

genetic code evolutionary algorithms

Descriptors:

  • NZ2_7: Bioinformatics
  • NZ2_8: Computational biology
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Małgorzata Wnętrzak 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 88 440 PLN

Project start date (Y-m-d): 2018-08-08

Project end date (Y-m-d): 2020-08-07

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer (8 500 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Optimization of the standard genetic code in terms of two mutation types: Point mutations and frameshifts
    Authors:
    Małgorzata Wnętrzak, Paweł Błażej, Paweł Mackiewicz
    Academic press:
    BioSystems (rok: 2019, tom: 181, strony: 44-50), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biosystems.2019.04.012 - link to the publication
  2. Basic principles of the genetic code extension
    Authors:
    Paweł Błażej, Małgorzata Wnętrzak, Dorota Mackiewicz, Paweł Mackiewicz
    Academic press:
    Royal Society Open Science (rok: 2020, tom: 7, strony: 191384), Wydawca: The Royal Society Publishing
    Status:
    Published
    DOI:
    10.1098/rsos.191384 - link to the publication
  3. Many alternative and theoretical genetic codes are more robust to amino acid replacements than the standard genetic code
    Authors:
    Paweł Błażej, Małgorzata Wnętrzak, Dorota Mackiewicz, Przemysław Gagat, Paweł Mackiewicz
    Academic press:
    Journal of Theoretical Biology (rok: 2019, tom: 464, strony: 21-32), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jtbi.2018.12.030 - link to the publication
  4. The influence of different types of translational inaccuracies on the genetic code structure
    Authors:
    Paweł Błażej, Małgorzata Wnetrzak, Dorota Mackiewicz, Paweł Mackiewicz
    Academic press:
    BMC Bioinformatics (rok: 2019, tom: 20, strony: 114-128), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12859-019-2661-4 - link to the publication
  1. Properties of the Standard Genetic Code and Its Alternatives Measured by Codon Usage from Corresponding Genomes
    Authors:
    Małgorzata Wnętrzak, Paweł Błażej, Paweł Mackiewicz
    Conference:
    13th International Joint Conference on Biomedical Engineering Systems and Technologies (rok: 2020, ), Wydawca: SciTePress
    Data:
    konferencja 24-26.02.2020
    Status:
    Published
  2. The impact of the transversion/transition ratio on the optimal genetic code graph partition
    Authors:
    Daniyah A. Aloqalaa, Dariusz R. Kowalski, Paweł Błażej, Małgorzata Wnętrzak, Dorota Mackiewicz, Paweł Mackiewicz
    Conference:
    12th International Joint Conference on Biomedical Engineering Systems and Technologies (rok: 2019, ), Wydawca: SciTePress
    Data:
    konferencja 22-24.02.2019
    Status:
    Published

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