Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mathematical modeling of chromatographic process dynamics for proteins with unstable structure

2017/27/B/ST8/00385

Keywords:

chromatography proteins monoclonal antibodies mathematical modeling

Descriptors:

  • ST8_1: Chemical engineering, technical chemistry, environmental engineering, sanitary engineering, engineering of chemical processes
  • ST8_3: Computational engineering, computer-aided modelling, design and manufacturing

Panel:

ST8 - Production and processes engineering: modelling, product design, process design and control, construction methods and engineering, power units and systems

Host institution :

Politechnika Rzeszowska im. Ignacego Łukasiewicza, Wydział Chemiczny

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dorota Antos 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 975 140 PLN

Project start date (Y-m-d): 2018-07-17

Project end date (Y-m-d): 2021-07-16

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Chromatograf cieczowy HPLC (270 000 PLN)
  2. Urządzenie do zatężania roztworu na zimno (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (4)
  1. A high-throughput method for fast detecting unfolding of monoclonal antibodies on cation exchange resins
    Authors:
    Artur Stańczak, Krystian Baran, Dorota Antos
    Academic press:
    Journal of Chromatography A (rok: 2020, tom: 1634, strony: 461688), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2020.461688 - link to the publication
  2. Dissociation events during processing of monoclonal antibodies on strong cation exchange resins
    Authors:
    Izabela Poplewska, Patrycja Zimoch, Dorota Antos
    Academic press:
    Journal of Chromatography A (rok: 2022, tom: 1670, strony: 462969), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2022.462969 - link to the publication
  3. Effects of negative and positive cooperative adsorption of proteins on hydrophobic interaction chromatography media
    Authors:
    Muca R., Kołodziej M., Piątkowski W., Carta G., Antos D.
    Academic press:
    Journal of Chromatography A (rok: 2020, tom: 1625, strony: 461309), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2020.461309 - link to the publication
  4. A case study of the mechanism of unfolding and aggregation of a monoclonal antibody in ion exchange chromatography
    Authors:
    Poplewska I., Piątkowski W., Antos D.
    Academic press:
    Journal of Chromatography A (rok: 2021, tom: 1636, strony: 461687), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chroma.2020.461687 - link to the publication
  1. BADANIA DYNAMIKI PROCESU CHROMATOGRAFII BIAŁEK O NIESTABILNEJ STRUKTURZE
    Authors:
    Krystian Baran, Artur Stańczak, Dorota Antos
    Conference:
    Konferencja: "Analiza zagadnienia, analiza wyników - wystąpienie młodego naukowca" (rok: 2019, ), Wydawca: Organizator Konferencji
    Data:
    konferencja 21.05.2019
    Status:
    Published
  2. P-T-247 "Methods for Detecting Unfolding of Monpclonal Antibodies on Cation Exchange Resins"
    Authors:
    Artur Stańczak, Krystian Baran,Bartłomiej Filip, Dorota Antos
    Conference:
    32 Internatioal Syphosium on Preparative and Process Chromatography PREP2019 (rok: 2019, ), Wydawca: Organizing Comitee
    Data:
    konferencja 07-10.07.2019
    Status:
    Published
  3. L-308 "Quantification of Unfolding and Aggregation of Monoclonal Antibodies on Cation Exchange Resins"
    Authors:
    Artur Stańczak, Krystian Baran, Izabela Poplewska, Dorota Antos
    Conference:
    32 Internatioal Syphosium on Preparative and Process Chromatography PREP2019 (rok: 2019, ), Wydawca: Organizing Comitee
    Data:
    konferencja 07-10.07.2019
    Status:
    Published
  4. P4-26 "Adsorption behavior of unstabile proteins in hydrophobic interaction chromatography"
    Authors:
    Muca R., Piątkowski W., Antos D.
    Conference:
    23 Polish Conference on Chemical and Process Engineering (rok: 2019, ), Wydawca: PAN – Committee of Chemical & Process Engineering & Warsaw University of Technology, Poland
    Data:
    konferencja Jachranka, 2-5.06.2019
    Status:
    Published

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