Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of the melanin's phototoxicity in cells in vitro and in model systems

2017/27/B/ST5/02631

Keywords:

melanin photoreactivity reactive oxygen species skin phototoxicity solar radiation

Descriptors:

  • ST5_16:
  • ST4_17: Chemical reactions: mechanisms, thermodynamics, kinetics
  • NZ1_3: Biophysics

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Tadeusz Sarna 

Number of co-investigators in the project: 5

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 757 831 PLN

Project start date (Y-m-d): 2018-07-12

Project end date (Y-m-d): 2023-07-11

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stacja robocza z specjalistycznym oprogramowaniem (79 076 PLN)
  2. Moduł skanujący z laserami (498 555 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Fine Particulate Matter-Induced Oxidative Stress Mediated by UVA-Visible Light Leads to Keratinocyte Damage
    Authors:
    Krystian Mokrzyński, Olga Krzysztyńska-Kuleta, Marcin Zawrotniak, Michał Sarna and Tadeusz Sarna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(19), strony: 45311), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221910645 - link to the publication
  2. Photoreactivity and phototoxicity of experimentally photodegraded hair melanosomes from individuals of different skin phototypes
    Authors:
    Krystian Mokrzyński, Michał Sarna, Tadeusz Sarna
    Academic press:
    Journal of Photochemistry and Photobiology B: Biology (rok: 2023, tom: 243, strony: 112704), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotobiol.2023.112704 - link to the publication
  3. Photoreactivity of Hair Melanin from Different Skin Phototypes—Contribution of Melanin Subunits to the Pigments Photoreactive Properties
    Authors:
    Krystian Mokrzyn , Shosuke Ito, Kazumasa Wakamatsu,Theodore G. Camenish,Tadeusz Sarna and Michal Sarna
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(9), strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094465 - link to the publication
  4. Can l-ascorbic acid and trans-resveratrolprotect HaCaT cells from fine particulate matter toxicity?
    Authors:
    Krystian Mokrzyński, Olga Krzysztyńska-Kuleta, Mateusz Wojtala, Dawid Wnuk, Michał Sarna, Tadeusz Sarna
    Academic press:
    Photochemistry and Photobiology (rok: 2023, tom: brak, strony: brak), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/php.13829 - link to the publication
  5. Interaction of melanin with metal ions modulates their cytotoxic potential
    Authors:
    Tadeusz Sarna, Harold M. Swartz, Andrzej Zadlo
    Academic press:
    Applied Magnetic Resonance (rok: 2022, tom: 53, strony: 105-121), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00723-021-01386-3 - link to the publication
  6. Melanoma, Melanin, and Melanogenesis: The Yin and Yang Relationship
    Authors:
    Radomir M Slominski, Tadeusz Sarna, Przemysław M Płonka, Chander Raman, Anna A Brożyna, Andrzej T Slominski
    Academic press:
    Frontiers in Oncology (rok: 2022, tom: 12, strony: 842496), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2022.842496 - link to the publication
  7. The effect of oxidative degradation of Dopa-melanin on its basic physicochemical properties and photoreactivity
    Authors:
    Mokrzyński Krystian, Żądło Andrzej, Szewczyk Grzegorz, Sarna Michał, Camenisch Theodore G., Ito Shosuke, Wakamatsu Kazumasa, Sarna Tadeusz
    Academic press:
    Pigment Cell & Melanoma Research , Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication

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