Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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The role of estrogens in the regulation of PRODH/POX-dependent apoptosis/autophagy in breast cancer cells (MCF-7)

2017/27/N/NZ7/01770

Keywords:

estradiol 2-methoxyestradiol PRODH POX apoptosis authophagy breast cancer

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ilona Ościłowska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 207 900 PLN

Project start date (Y-m-d): 2018-06-27

Project end date (Y-m-d): 2022-06-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (3)
  1. Troglitazone-induced PRODH/POX-dependent apoptosis occurs in the absence of estradiol or ERβ in ER-negative breast cancer cells.
    Authors:
    Lewoniewska Sylwia, Ościłowska Ilona, Huynh Thi Yen Ly, Prokop Izabela, Baszanowska Weronika, Bielawska Katarzyna, Pałka Jerzy.
    Academic press:
    Journal of Clinical Medicine (rok: 2021, tom: 10, strony: 18 pp., Article ID: 4641), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm10204641 - link to the publication
  2. Proline Oxidase silencing inhibits P53-dependent apoptosis in MCF-7 breast cancer cells
    Authors:
    Ilona Oscilowska, Thi YL Huynh, Weronika Baszanowska, Izabela Prokop, Arkadiusz Surazynski, Mauro Galli, Piotr Zabielski, Jerzy Palka
    Academic press:
    Amino Acids (rok: 2021, tom: 53, strony: 1943-1956), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-021-03013-8 - link to the publication
  3. Understanding the role of estrogen receptor status in PRODH/POX-dependent apoptosis/survival in breast cancer cells.
    Authors:
    Lewoniewska Sylwia, Ościłowska Ilona, Forlino Antonella, Pałka Jerzy.
    Academic press:
    Biology (rok: 2021, tom: 10, strony: 15pp, Article ID 1314), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biology10121314 - link to the publication
  1. Estrogeny regulują PRODH/POX-zależną indukcję apoptozy.
    Authors:
    Lewoniewska Sylwia, Prokop Izabela, Huynh Thi Yen Ly, Baszanowska Weronika, Zaręba Ilona.
    Conference:
    III Poznańska Konferencja "Współczesna analityka farmaceutyczna i biomedyczna w ochronie zdrowia". Poznań, konferencja on-line, 04-05.06.2020. (rok: 2020, ), Wydawca: Wydawnictwo Naukowe Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
    Data:
    konferencja 04-05.06.2020
    Status:
    Published
  2. Down-regulation of estrogen receptor function facilitate proline dehydrogenase/proline oxidase-dependent apoptosis in MCF-7 breast cancer cells.
    Authors:
    Zareba I, Baszanowska W, Lewoniewska S, Huynh TYL, Prokop I, Rysiak E, Palka J
    Conference:
    XVIII International Congress of Medical Sciences (rok: 2019, ), Wydawca: ASSOCIATION OF MEDICAL STUDENTS IN BULGARIASOFIA
    Data:
    konferencja 2019-05-09- 12
    Status:
    Published
  3. The effect of estradiol on proline dehydrogenase/proline oxidase-mediated apoptosis in breast cancer MCF-7 cells.
    Authors:
    Zareba I, Prokop I, Baszanowska W, Celinska-Janowicz K, Surazynski A, Miltyk W, Petelska E, Cywoniuk A, Palka J
    Conference:
    IX Konwersatorium Chemii Medycznej (rok: 2018, ), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 2018-09-13- 15
    Status:
    Published