Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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In quest for the mechanism of transport of vitamin B12-peptide nucleic acid conjugates to E. coli cells

2017/27/N/NZ1/00986

Keywords:

vitamin B12 peptide nucleic acids ABC transporter molecular dynamics BtuF BtuCD E. coli mutants

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_9: Biotechnology
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Pieńko 

Number of co-investigators in the project: 3

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 201 598 PLN

Project start date (Y-m-d): 2018-08-10

Project end date (Y-m-d): 2022-08-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. stacja robocza do obliczeń równoległych (30 000 PLN)
  2. monitor do stacji roboczej.

Information in the final report

  • Publication in academic press/journals (3)
  1. Vitamin B12-peptide nucleic acids use the BtuB receptor to pass through the Escherichia coli outer membrane
    Authors:
    Tomasz Pieńko, Jakub Czarnecki, Marcin Równicki, Monika Wojciechowska, Aleksandra J. Wierzba, Dorota Gryko, Dariusz Bartosik, Joanna Trylska
    Academic press:
    Biophysical Journal (rok: 2021, tom: 120(4), strony: 725-737), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.bpj.2021.01.004 - link to the publication
  2. Computational Methods Used to Explore Transport Events in Biological Systems
    Authors:
    Tomasz Pieńko, Joanna Trylska
    Academic press:
    J. Chem. Inf. Model. (rok: 2019, tom: 59(5), strony: 1772-1781), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jcim.8b00974 - link to the publication
  3. Extracellular loops of BtuB facilitate transport of vitamin B12 through the outer membrane of E. coli
    Authors:
    Tomasz Pieńko, Joanna Trylska
    Academic press:
    PLOS Computational Biology (rok: 2020, tom: 16(7), strony: e1008024), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pcbi.1008024 - link to the publication

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