Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Peritoneal dialysis biocompatibility - peritoneal mesothelium - arterial endothelium

2017/27/B/NZ4/01675

Keywords:

peritoneal dialysis - biocompatibility-peritoneal mesothelium - arterial endothelium - glutathione - sulodexide

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Bręborowicz 

Number of co-investigators in the project: 3

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 658 800 PLN

Project start date (Y-m-d): 2018-06-29

Project end date (Y-m-d): 2022-06-28

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Automatyczny licznik komórek (12 000 PLN)
  2. Wyposażenie inkubatora do hodowli komórek (komora do hipoksji, czujnik przepływu).
  3. Spektrofotometryczny czytnik do płytek (44 000 PLN)
  4. Inkubator CO2 do hodowli komórkowej (47 000 PLN)
  5. Zbiornik do przechowywania prób CryoMaster.

Information in the final report

  • Publication in academic press/journals (5)
  1. L-2-Oxothiazolidine-4-Carboxylic Acid slow down dialysate-induced senescence in human peritoneal mesothelial cells
    Authors:
    P.Sosinska-Zawierucha, B. Mackowiak, B. Begier-Krasinska, K. Hoppe, A.Breborowicz
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 69, strony: 943-950), Wydawca: Uniwersytet Jagiellonski Kraków
    Status:
    Published
    DOI:
    10.26402/jpp.2018.6.08 - link to the publication
  2. Secretory activity of the coronary artery endothelial cells in conditions of the peritoneal dialysis
    Authors:
    Misian Monika, Baum Ewa, Bręborowicz Andrzej
    Academic press:
    Renal Failure (rok: 2022, tom: 44, strony: 54-61), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/0886022X.2021.2023024 - link to the publication
  3. Uremic serum induces prothrombic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells
    Authors:
    Sosinska-Zawierucha P, Bręborowicz A
    Academic press:
    Renal Failure (rok: 2021, tom: 43, strony: 401-405), Wydawca: Taylor @ Francis
    Status:
    Published
    DOI:
    10.1080/0886022X,2021.1890617 - link to the publication
  4. N-Acetylcysteine and Sulodexide reduce the prothrombotic effect of uremic serum on the venous endothelial cells
    Authors:
    P.Sosinska-Zawierucha, B.Mackowiak, A. Bręborowicz
    Academic press:
    Kidney & Blood Pressure Research (rok: 2019, tom: 44, strony: 277-285), Wydawca: S.Karger AG Basel
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Sulodexide modulates the dialysate effect on the peritoneal mesothelium
    Authors:
    M.Misian, E,Baum, A. Bręborowicz
    Academic press:
    Journal of Physiology & Pharmacology (rok: 2019, tom: 70, strony: wersja online bez nadanych stron), Wydawca: Uniwersytet Jagielloński Kraków
    Status:
    Published
    DOI:
    10.26402/jpp.2019.6.15 - link to the publication

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