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Information on the principal investigator and host institution

Information of the project and the call

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Comprehensive research on enzymatic hydrolysis of native and chemically modified 5' RNA structures by Nudix protein family.

2017/27/B/NZ1/01859

Keywords:

RNA metabolism cap structure hydrolases enzyme kinetic

Descriptors:

  • NZ1_1:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Edward Darżynkiewicz 

Number of co-investigators in the project: 8

Call: OPUS 14 - announced on 2017-09-15

Amount awarded: 1 580 600 PLN

Project start date (Y-m-d): 2018-10-08

Project end date (Y-m-d): 2023-10-07

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  1. Mammalian Nudt15 hydrolytic and binding activity on methylated guanosine mononucleotides
    Authors:
    Łukaszewicz M., Ferenc-Mrozek A., Kokosza J., Stefaniuk A., Stępiński J., Bojarska E., Darżynkiewicz E.
    Academic press:
    European Biophysics Journal (rok: 2023, tom: 52, strony: 487-495), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00249-023-01678-5 - link to the publication
  2. N2 modified dinucleotide cap analogs as a potent tool for mRNA engineering
    Authors:
    Grzela R., Piecyk K., Stankiewicz-Drogoń A., Pietrow P., Łukaszewicz M., Kurpiejewski K., Darżynkiewicz E., Jankowska-Anyszka M.
    Academic press:
    RNA (rok: 2023, tom: 29, strony: 200-216), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.079460.122 - link to the publication
  3. Decapping scavenger enzyme activity towards N2-substituted 5' end mRNA cap analogues.
    Authors:
    Pietrow P., Ferenc-mrozek A., Piecyk K., Bojarska E., Darżynkiewicz E., Jankowska-Anyszka M.
    Academic press:
    ACS Omega (rok: 2019, tom: 4, strony: 17576-17580), Wydawca: ACS Publication
    Status:
    Published
    DOI:
    10.1021/acsomega.9b02715 - link to the publication
  4. Contribution of Nudt12 enzyme to differentially methylated dinucleotides of 5'RNA cap structure
    Authors:
    Łukaszewicz M., Ferenc-Mrozek A., Bojarska E., Stelmach J., Stępiński J., Darzynkiewicz E.
    Academic press:
    BBA - General Subjects (rok: 2023, tom: 1867, strony: 130400), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagen.2023.130400 - link to the publication
  5. Effect of the His-Tag location on decapping scavenger enzymes and their hydrolytic activity toward cap analogs
    Authors:
    Ferenc-Mrozek A., Bojarska E., Stępiński J., Darżynkiewicz E., Łukaszewicz M.
    Academic press:
    ACS Omega (rok: 2020, tom: 5, strony: 10759-10766), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.0c00304 - link to the publication
  6. Insight into the Binding and Hydrolytic Preferences of hNudt16 Based on Nucleotide Diphosphate Substrates
    Authors:
    Chrabąszczewska M., Winiewska-Szajewska M., Ostrowska N., Bojarska E., Stępiński J., Mancewicz Ł., Łukaszewicz M., Trylska J., Taube M., Kozak M., Darżynkiewicz E., Grzela R.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45679), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222010929 - link to the publication
  1. Investigation of some kinetic properties of Nudt12 towards dinucleotide substrates
    Authors:
    Łukaszewicz M., Ferenc-Mrozek A., Bojarska E., Stępiński J., Darżynkiewicz E.
    Conference:
    XVIII Congress of the Polish Biophysical Society (PTBF) (rok: 2022, ), Wydawca: Polskie Towarzystwo Biofizyczne
    Data:
    konferencja 6-9 Wrzesień
    Status:
    Published
    DOI:
    link to the publication
  2. N2-modified cap analogs - a very potent tool for mRNA engineering
    Authors:
    Grzela R., Piecyk K., Stankiewicz-Drogoń A., Pietrow P., Łukaszewicz M., Kurpiejewski K., Darżynkiewicz E. Jankowska-Anyszka M.
    Conference:
    XVIII Congress of the Polish Biophysical Society (PTBF) (rok: 2022, ), Wydawca: Polskie Towarzystwo Biofizyczne
    Data:
    konferencja 6-9 Wrzesień
    Status:
    Published
    DOI:
    link to the publication

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