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Information on the principal investigator and host institution

Information of the project and the call

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Small Changes - Huge Impact: The role of S-palmitoylation and S-nitrosylation interplay in the mice model of depression

2017/26/E/NZ4/00637

Keywords:

synaptic plasticity animal model of depression S-palmitoylation dendritic spines ketamine

Descriptors:

  • NZ4_7:
  • NZ4_10:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Jakub Mateusz Włodarczyk 

Number of co-investigators in the project: 5

Call: SONATA BIS 7 - announced on 2017-06-14

Amount awarded: 2 782 200 PLN

Project start date (Y-m-d): 2018-04-10

Project end date (Y-m-d): 2024-04-09

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  1. 3dSpAn: An interactive software for 3D segmentation and analysis of dendritic spines
    Authors:
    Nirmal Das, Ewa Baczynska, Monika Bijata, Blazej Ruszczycki, Andre Zeug, Dariusz Plewczynski, Punam Kumar Saha, Evgeni Ponimaskin, Jakub Wlodarczyk, Subhadip Basu
    Academic press:
    Neuroinformatics (rok: 2022, tom: 20, strony: 679-698), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s12021-021-09549-0 - link to the publication
  2. DHHC7-mediated palmitoylation of the accessory proteinbarttin critically regulates the functions of ClC-K chloridechannels
    Authors:
    Gorinski N., Wojciechowski D., Guseva D., Galil D.A., Mueller F.A., Wirth A., Thiemann S., Zeug A., Schmidt S., Zareba-Kozioł M., Wlodarczyk J., Skryabin B.V. Glage S., Fischer M., Al-Samir S., Kerkenberg N., Hohoff C., Zhang W., Endeward V., Ponimaskin E.
    Academic press:
    J. Biol Chem (rok: 2020, tom: 295, strony: 5970-5983), Wydawca: The American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.RA119.011049 - link to the publication
  3. Quantification of Dendritic Spines Remodeling under Physiological Stimuli and in Pathological Conditions
    Authors:
    Ewa Bączyńska, Katarzyna Karolina Pels, Subhadip Basu, Jakub Włodarczyk, Błażej Ruszczycki
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4053), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms22084053 - link to the publication
  4. Nowoczesne techniki wykorzystywane do badań eksperymentalnych zaburzonej plastyczności neuronalnej w depresji
    Authors:
    Bączyńska E, Krzystyniak A, Zaręba-Kozioł M, Figiel I, Włodarczyk J, Wójtowicz T
    Academic press:
    Kosmos (rok: 2020, tom: 69, strony: 185-200), Wydawca: Polskie Towarzystwo Przyrodników
    Status:
    Published
    DOI:
    10.36921/kos.2020_2637 - link to the publication
  5. The cell adhesion protein dystroglycan afects the structural remodeling of dendritic spines
    Authors:
    Figiel I., Kaczyńska E., Wojtowicz T., Magnowska M., Buszka A., Bijana M., Włodarczyk J.
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 2506), Wydawca: Naturę
    Status:
    Published
    DOI:
    10.1038/s41598-022-06462-7 - link to the publication
  6. Activation of the 5-HT7 receptor and MMP-9 signaling module in the hippocampal CA1 region is necessary for the development of depressive-like behavior
    Authors:
    Bijata M., Bączyńska E, Müller FE., Bijata K., Masternak J., Krzystyniak A., Szewczyk B., Siwiec M., Antoniuk S., Roszkowska M., Figiel I., Magnowska M., Olszyński KH., Wardak AD., Hogendorf A., Ruszczycki B., Gorinski N., Labus J., Stępień T., Tarka S., Bojarski AJ., Tokarski K., Filipkowski RK., Ponimaskin E., Wlodarczyk J.
    Academic press:
    Cell Reports (rok: 2022, tom: 38, strony: 2211-1247), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.celrep.2022.110532. - link to the publication
  7. RFCM-PALM: In-Silico Prediction of S-Palmitoylation Sites in the Synaptic Proteins for Male/Female Mouse Data
    Authors:
    Soumyendu Sekhar Bandyopadhyay, Anup Kumar Halder, Monika Zaręba-Kozioł, Anna Bartkowiak-Kaczmarek, Aviinandaan Dutta, Piyali Chatterjee, Mita Nasipuri, Tomasz Wójtowicz, Jakub Wlodarczyk, Subhadip Basu
    Academic press:
    International journal of molecular sciences (rok: 2021, tom: 22, strony: 9901), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22189901 - link to the publication
  8. Phosphorylation of PSD-95 at serine 73 in dCA1 is required for extinction of contextual fear
    Authors:
    Ziółkowska M., Borczyk M., Cały A., Tomaszewski KF., Nowacka A., Nalberczak-Skóra M., Śliwińska MA., Łukasiewicz K., Skonieczna E., Wójtowicz T., Wlodarczyk J., Bernaś T., Salamian A., Radwanska K.
    Academic press:
    PLOS Biology (rok: 2023, tom: 21, strony: e3002106), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pbio.3002106 - link to the publication
  9. Combination of dasatinib and quercetin improves cognitive abilities in aged male Wistar rats, alleviates inflammation and changes hippocampal synaptic plasticity and histone H3 methylation profile
    Authors:
    Krzystyniak A., Wesierska M., Petrazzo G., Gadecka A., Dudkowska M., Bielak-Zmijewska A., Kosieniak G., Figiel I., Włodarczyk J., Sikora E
    Academic press:
    Aging (rok: 2022, tom: 14, strony: 572-595), Wydawca: Aging (Albany NY)
    Status:
    Published
    DOI:
    10.18632/aging.203835 - link to the publication
  10. Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin.
    Authors:
    Schill Y., Bijata M., Kopach O., Cherkas V., Abdel-Gali D., Bohm K., Schwab MH., Matsuda M., Compan V., Basu S., Bijata K., Wlodarczyk J., Bard L., Cole N., Dityatev A., Zeug A., Rusakov DA., Ponimaskin E
    Academic press:
    Communications Biology (rok: 2020, tom: 3, strony: 76), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s42003-020-0791-x - link to the publication
  11. A chronic unpredictable stress protocol to model anhedonic and resilient behaviors in C57BL/6J mice
    Authors:
    Bijata M., Baczyńska E., Włodarczyk J.
    Academic press:
    STAR Protocols (rok: 2022, tom: 3, strony: 101659), Wydawca: Cell Press
    Status:
    Published
    DOI:
    10.1016/j.xpro.2022.101659 - link to the publication
  12. Prophylactic Ketamine Treatment Promotes Resilience to Chronic Stress and Accelerates Recovery: Correlation with Changes in Synaptic Plasticity in the CA3 Subregion of the Hippocampus.
    Authors:
    Krzystyniak A., Baczynska E., Magnowska M., Antoniuk S., Roszkowska M., Zareba-Koziol M., Das N., Basu S., Pikula M., Wlodarczyk J.
    Academic press:
    Int. J. Mol. Sci. (rok: 2019, tom: 20, strony: 1726), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms20071726 - link to the publication
  13. S-Palmitoylation of Synaptic Proteins as a Novel Mechanism Underlying Sex-Dependent Differences in Neuronal Plasticity
    Authors:
    Zareba-Koziol M., Bartkowiak-Kaczmarek A., Roszkowska, M. Bijata K., Figiel I, Kumar Halder A., Kamińska P., Müller F. E.,, Basu S., Zhang W., Ponimaskin E., Włodarczyk J.
    Academic press:
    International journal of molecular sciences (rok: 2021, tom: 22, strony: 6253), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22126253 - link to the publication
  14. Attenuated palmitoylation of serotonin receptor 5- HT1A affects receptor function and contributes to depression-like behaviors
    Authors:
    Gorinski N., Bijata M., Prasad S., Wirth A., Galil D.A., Zeug A., Bazovkina D., Kondaurova E., Kulikova E., Ilchibaeva T., Zareba-Koziol M., Papaleo F., Scheggia D., Kochlamazashvili G., Dityatev A., Smyth I., Krzystyniak A., Wlodarczyk J., Richter D.E., Strekalova T., Sigrist S., Bang C., Hobuß L., Fiedler J., Thum T., Naumenko V.S., Pandey G., Ponimaskin E.
    Academic press:
    Nature Communications (rok: 2019, tom: 10, strony: 3924), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-019-11876-5 - link to the publication
  15. PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD
    Authors:
    Nowacka A., Borczyk M, Salamian A, Wójtowicz T, Włodarczyk J, Radwanska K
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 45668), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-58989-2 - link to the publication

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