Understanding the interactions of zinc with metal-sensing transcriptional regulators from Mycobacterial ArsR-family

2017/26/D/ST5/00372

Keywords

Descriptors

  • ST5_14: Chemia koordynacyjna
  • ST5_16: Chemia biologiczna
  • ST5_24: Chemia nieorganiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Wrocławski, Wydział Chemii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Sławomir Potocki

Number of co-investigators in the project: 4

Call

SONATA 13 – announced on 2017-06-14

Amount awarded
908 700 PLN
Project start date
2018-04-20
Project end date
2023-04-19
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer przenośny (2 pcs). Cost: 8 056 PLN
  2. pH-metr. Cost: 5 000 PLN
  3. potencjometr. Cost: 120 000 PLN
  4. zasilacz awaryjny. Cost: 1 092 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Zn(II) and Cd(II) Complexes of AMT1/MAC1 Homologous Cys/His-Rich Domains: So Similar yet So Different

    Authors:
    Rola Anna, Potok Paulina, Mos Magdalena, Gumienna-Kontecka Elżbieta, Potocki Sławomir
    Academic press:
    Inorganic Chemistry (year: 2022, volume: 61, pages: 14333-14343), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c02080 – link to the publication
  2. Bacterial M10 metallopeptidase as a medicinal target – coordination chemistry of possible metal-based inhibition

    Authors:
    Potok Paulina, Potocki Sławomir
    Academic press:
    Dalton Transactions (year: 2022, volume: 51, pages: 14882-14893), Publisher: RCS
    Status:
    Published
    DOI:
    10.1039/d2dt02265f – link to the publication
  3. Coordination Properties of the Zinc Domains of BigR4 and SmtB Proteins in Nickel Systems─Designation of Key Donors

    Authors:
    Rola Anna, Potok Paulina, Wieczorek Robert, Mos Magdalena, Gumienna-Kontecka Elżbieta, Potocki Sławomir
    Academic press:
    Inorganic Chemistry (year: 2022, volume: 61, pages: 9454-9468), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c00319 – link to the publication
  4. Sometimes less is more-the impact of the number of His residues on the stability of Zn(II)–SmtB and BigR4 α-5 domain complexes

    Authors:
    Rola Anna, Wieczorek Robert, Kozłowski Henryk, Krzywoszyńska Karolina, Potocki Sławomir
    Academic press:
    Dalton Transactions (year: 2021, volume: 50, pages: 12118-12129), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1dt01690c – link to the publication
  5. Pneumococcal HxxHxH triad – Copper(II) interactions – How important is the 'x'?

    Authors:
    Slawomir Potocki, Paula Delgado, Dorota Dudek, Anna Janicka-Kłos, Henryk Kozłowski, Magdalena Rowińska-Żyrek
    Academic press:
    Inorganica Chimica Acta (year: 2019, volume: 488, pages: 255-259), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ica.2019.01.029 – link to the publication
  6. Histidine-Rich C-Terminal Tail of Mycobacterial GroEL1 and Its Copper Complex─The Impact of Point Mutations

    Authors:
    Rola Anna, Palacios Oscar, Capdevila Merce, Valensin Daniela, Gumienna-Kontecka Elżbieta, Potocki Sławomir
    Academic press:
    Inorganic Chemistry (year: 2023, volume: 62, pages: 6893-6908), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c04486 – link to the publication
  7. Triplet of cysteines – Coordinational riddle?

    Authors:
    Karolina Krzywoszyńska, Jolanta Swiątek-Kozłowska, Sławomir Potocki, Małgorzata Ostrowska, Henryk Kozłowski
    Academic press:
    Journal of Inorganic Biochemistry (year: 2020, volume: 204 (110957), pages: 46032), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110957 – link to the publication

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Graphic design and implementation: Jakub Piotrowski