Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Understanding the interactions of zinc with metal-sensing transcriptional regulators from Mycobacterial ArsR-family

2017/26/D/ST5/00372

Keywords:

ArsR-family transcriptional regulators SmtB protein peptides coordination chemistry zinc thermodynamics Mycobacterium tuberculosis NMR microbiological studies

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:
  • ST5_24:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sławomir Potocki 

Number of co-investigators in the project: 4

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 908 700 PLN

Project start date (Y-m-d): 2018-04-20

Project end date (Y-m-d): 2023-04-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. zasilacz awaryjny (1 092 PLN)
  2. pH-metr (5 000 PLN)
  3. potencjometr (120 000 PLN)
  4. komputer przenośny (2 szt.) (8 056 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Histidine-Rich C-Terminal Tail of Mycobacterial GroEL1 and Its Copper Complex─The Impact of Point Mutations
    Authors:
    Rola Anna, Palacios Oscar, Capdevila Merce, Valensin Daniela, Gumienna-Kontecka Elżbieta, Potocki Sławomir
    Academic press:
    Inorganic Chemistry (rok: 2023, tom: 62, strony: 6893-6908), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c04486 - link to the publication
  2. Sometimes less is more-the impact of the number of His residues on the stability of Zn(II)–SmtB and BigR4 α-5 domain complexes
    Authors:
    Rola Anna, Wieczorek Robert, Kozłowski Henryk, Krzywoszyńska Karolina, Potocki Sławomir
    Academic press:
    Dalton Transactions (rok: 2021, tom: 50, strony: 12118-12129), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d1dt01690c - link to the publication
  3. Bacterial M10 metallopeptidase as a medicinal target – coordination chemistry of possible metal-based inhibition
    Authors:
    Potok Paulina, Potocki Sławomir
    Academic press:
    Dalton Transactions (rok: 2022, tom: 51, strony: 14882-14893), Wydawca: RCS
    Status:
    Published
    DOI:
    10.1039/d2dt02265f - link to the publication
  4. Pneumococcal HxxHxH triad – Copper(II) interactions – How important is the 'x'?
    Authors:
    Slawomir Potocki, Paula Delgado, Dorota Dudek, Anna Janicka-Kłos, Henryk Kozłowski, Magdalena Rowińska-Żyrek
    Academic press:
    Inorganica Chimica Acta (rok: 2019, tom: 488, strony: 255-259), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ica.2019.01.029 - link to the publication
  5. Zn(II) and Cd(II) Complexes of AMT1/MAC1 Homologous Cys/His-Rich Domains: So Similar yet So Different
    Authors:
    Rola Anna, Potok Paulina, Mos Magdalena, Gumienna-Kontecka Elżbieta, Potocki Sławomir
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 14333-14343), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c02080 - link to the publication
  6. Triplet of cysteines – Coordinational riddle?
    Authors:
    Karolina Krzywoszyńska, Jolanta Swiątek-Kozłowska, Sławomir Potocki, Małgorzata Ostrowska, Henryk Kozłowski
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2020, tom: 204 (110957), strony: 45301), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110957 - link to the publication
  7. Coordination Properties of the Zinc Domains of BigR4 and SmtB Proteins in Nickel Systems─Designation of Key Donors
    Authors:
    Rola Anna, Potok Paulina, Wieczorek Robert, Mos Magdalena, Gumienna-Kontecka Elżbieta, Potocki Sławomir
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 9454-9468), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c00319 - link to the publication

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