Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Assesment the role of cannabidiol in the regulation of fatty acid transport proteins (FAT/CD36, FABPpm and FATP1,4,6) expression in cardiac muscle of rats with high fat diet induced insulin resistance.

2017/26/D/NZ3/01119

Keywords:

endocannabinoids cannabidiol obesity insulin resistance fatty acid transporters: FAT/CD36 FABPpm FATP1 4 6 sphingolipids lipids: FFA DAG TAG PL Chol Chol esters mitochondria cardiac muscle

Descriptors:

  • NZ3_2: Cell physiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Harasim-Symbor 

Number of co-investigators in the project: 6

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 771 860 PLN

Project start date (Y-m-d): 2018-04-13

Project end date (Y-m-d): 2021-04-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Aparat do perfuzji serca szczura w systemie Langendorffa wraz z oprogramowaniem ISOHEART i komputerem firmy Hugo Sachs Electronic (186 660 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (1)
  1. Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
    Authors:
    Patrycja Bielawiec, Ewa Harasim-Symbor and Adrian Chabowski
    Academic press:
    Frontiers in Endocrinology (rok: 2020, tom: 11, strony: 11 pp), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fendo.2020.00114 - link to the publication
  2. Cannabidiol - a phytocannabinoid that widely affects sphingolipid metabolism under conditions of brain insulin resistance.
    Authors:
    Charytoniuk Tomasz, Sztolsztener Klaudia, Harasim-Symbor Ewa, Berk Klaudia, Chabowski Adrian, Konstantynowicz-Nowicka Karolina
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2021, tom: 142, strony: 12pp), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.112057 - link to the publication
  3. Chronic Cannabidiol Administration Attenuates Skeletal Muscle De Novo Ceramide Synthesis Pathway and Related Metabolic Effects in a Rat Model of High-Fat Diet-Induced Obesity.
    Authors:
    Bielawiec Patrycja, Harasim-Symbor Ewa, Konstantynowicz-Nowicka Karolina, Sztolsztener Klaudia, Chabowski Adrian.
    Academic press:
    Biomolecules (rok: 2020, tom: 10(9), strony: 1241), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/biom10091241 - link to the publication
  4. Attenuation of Oxidative Stress and Inflammatory Response by Chronic Cannabidiol Administration Is Associated with Improved n-6/n-3 PUFA Ratio in the White and Red Skeletal Muscle in a Rat Model of High-Fat Diet-Induced Obesity
    Authors:
    Patrycja Bielawiec, Ewa Harasim-Symbor, Klaudia Sztolsztene, Karolina Konstantynowicz-Nowicka, Adrian Chabowski.
    Academic press:
    Nutrients (rok: 2021, tom: 13(5), strony: 1603), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/nu13051603 - link to the publication
  5. Cannabidiol downregulates myocardial de novo ceramide synthesis pathway in a rat model of high-fat diet-induced obesity.
    Authors:
    Charytoniuk Tomasz, Sztolsztener Klaudia, Bielawiec Patrycja, Chabowski Adrian, Konstantynowicz-Nowicka Karolina, Harasim-Symbor Ewa
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(4), strony: 17pp), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23042232 - link to the publication
  1. Cannabidiol regulates myocardial lipid metabolism in a rat model of obesity.
    Authors:
    Harasim-Symbor Ewa, Bielawiec Patrycja, Konstantynowicz-Nowicka Karolina
    Conference:
    31th Annual Symposium of the International Cannabinoid Research Society, Jerusalem, Israel (rok: 2021, ), Wydawca: International Cannabinoid Research Society
    Data:
    konferencja June 21-24
    Status:
    Published

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