Projects funded by the NCN

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Urolithin A as a metabolite of ellagitannins with potential neuroprotective activity - the research of mechanisms of this action in a model of Parkinson's disease

2017/26/D/NZ7/00748

Keywords:

urolithins mitochondrium oxidative stress autophagy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Kujawska 

Number of co-investigators in the project: 3

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 587 975 PLN

Project start date (Y-m-d): 2018-04-13

Project end date (Y-m-d): 2021-04-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. koncentrator próżniowy.
  2. System do transferu i wizualizacji białek Western-blot (125 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (2)
  1. Pomegranate Juice Ameliorates Dopamine Release and Behavioral Deficits in a Rat Model of Parkinson's Disease
    Authors:
    Kujawska, M.; Jourdes, M.; Witucki, Ł.; Karaźniewicz-Łada, M.; Szulc, M.; Górska, A.; Mikołajczak, P.Ł.; Teissedre, P.-L.; Jodynis-Liebert, J.
    Academic press:
    Brain Sciences (rok: 2021, tom: 11, strony: 1127), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/brainsci11091127 - link to the publication
  2. Potential of the ellagic acid-derived gut microbiota metabolite - Urolithin A in gastrointestinal protection.
    Authors:
    Kujawska M, Jodynis-Liebert J.
    Academic press:
    World J Gastroenterol. (rok: 2020, tom: 26(23), strony: 3170-3181), Wydawca: THE BAISHIDENG PUBLISHING GROUP
    Status:
    Published
    DOI:
    10.3748/wjg.v26.i23.3170 - link to the publication
  3. Neuroprotective Effects of Pomegranate Juice against Parkinson's Disease and Presence of Ellagitannins-Derived Metabolite-Urolithin A-In the Brain.
    Authors:
    Kujawska M, Jourdes M, Kurpik M, Szulc M, Szaefer H, Chmielarz P, Kreiner G, Krajka-Kuźniak V, Mikołajczak PŁ, Teissedre PL, Jodynis-Liebert J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 202), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21010202 - link to the publication
  1. Neuroprotective effect of Urolithin A against rotenone-induced mitochondrial impairment in a rat model Parkinson's disease
    Authors:
    Małgorzata Kujawska, Piotr Chmielarz, Michael Jourdes, Mirosław Andrusiewicz, Grzegorz Kreiner, Pierre-Louis Teissedre and Jadwiga Jodynis-Liebert
    Conference:
    he FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: FENS
    Data:
    konferencja 25-27 Sierpień
    Status:
    Published
  2. Pomegranate juice ameliorates dopamine release and motor and olfactory deficits in the rotenone-induced rat model of Parkinson's disease
    Authors:
    Kujawska, M; Witucki, Ł; Karaźniewicz-Łada, M; Szulc, M; Górska, A; Jodynis- Liebert, J
    Conference:
    The 2nd International Electronic Conference on Brain Sciences. (rok: 2021, ), Wydawca: MDPI
    Data:
    konferencja 15th of July 2021
    Status:
    Accepted for publication

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