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Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic strategy of depression.

2017/26/M/NZ7/01048

Keywords:

peptide formyl receptor 2 (ALX/FPR2) new ureidopropanamide agonist ALX/FPR2 resolution of inflammation depression

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • NZ3_6: Cell neurobiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Basta-Kaim 

Number of co-investigators in the project: 6

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 238 986 PLN

Project start date (Y-m-d): 2018-05-24

Project end date (Y-m-d): 2023-05-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (13)
  1. Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology.
    Authors:
    Tylek K., Trojan E., Regulska M., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 73, strony: 1004-1019), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00271-x - link to the publication
  2. The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology.
    Authors:
    Trojan E., Bryniarska N., Leśkiewicz M., Regulska M., Chamera K., Szuster-Głuszczak M., Leopoldo M., Lancivita E., Basta-Kaim A.
    Academic press:
    Current Neuropharmacology (rok: 2020, tom: 18, strony: 229-249), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X17666191019170244 - link to the publication
  3. The Potential Role of Dysfunctions in Neuron-Microglia Communication in the Pathogenesis of Brain Disorders
    Authors:
    Katarzyna Chamera, Ewa Trojan, Magdalena Szuster-Głuszczak, Agnieszka Basta-Kaim
    Academic press:
    Current Neuropharmacology (rok: 2020, tom: 18, strony: 408-430), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X17666191113101629 - link to the publication
  4. Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways.
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Regulska M., Bryniarska N., Curzytek K., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 2373), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092373 - link to the publication
  5. Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Francavilla F., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    ACS Chemical Neuroscience (rok: 2023, tom: 14, strony: 3869-3882), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acschemneuro.3c00525 - link to the publication
  6. The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression.
    Authors:
    Regulska M., Szuster-Głuszczak M., Trojan E., Leśkiewicz M., Basta-Kaim A.
    Academic press:
    Current Neuropharmacology (rok: 2021, tom: 19, strony: 278-293), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X18666200807144530 - link to the publication
  7. The Formyl Peptide Receptor 2 as a Target for Promotion of Resolution of Inflammation
    Authors:
    Trojan E., Leśkiewicz M., Lacivita E., LeopoldoM., Basta-Kaim A.
    Academic press:
    Current Neuropharmacology (rok: 2022, tom: Sep. 13, strony: 45297), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X20666220913155248 - link to the publication
  8. The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1-42)-Induced Neuroinflammation in Mouse Models of Alzheimer's Disease
    Authors:
    Trojan E., Tylek K., Schroder N., Kahl I., Brandenburg LO., Mastromarino M., Leopoldo M., Basta-Kaim A., Lacivita E.
    Academic press:
    Molecular neurobiology (rok: 2021, tom: 8, strony: 6203-6221), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-021-02543-2 - link to the publication
  9. Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study 4 of Organotypic Hippocampal Cultures
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Ghafir El Idrissi I., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 45316), Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    10.3390/xxxxx - link to the publication
  10. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders
    Authors:
    Mastromarino M., Favia M., Schepetkin I.A., Kirpotina L.N., Trojan E., Niso M., Carrieri A., Leśkiewicz M., Regulska M., Darida M., Rossignolo F., Fontana S., Quinn M.T., Basta-Kaim A., Leopoldo M., Lacivita E.
    Academic press:
    Journal of Medicinal Chemistry (rok: 2022, tom: 65, strony: 5004-5028), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c02203 - link to the publication
  11. The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures.
    Authors:
    Trojan E., Tylek K., Leśkiewicz M., Lasoń W, Brandenburg L.O., Leopoldo M., Lacivita E., Basta-Kaim A.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1524), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061524 - link to the publication
  1. Development of new drug-like FPR2 agonist with anti-inflammatory properties: study in the in vitro model of neuroinflammation
    Authors:
    Kinga Tylek, Monika Leśkiewicz, Ewa Trojan, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
    Conference:
    NEURONUS 2020 IBRO NEUROSCIENCE FORUM (rok: 2020, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 8.12-11.12.2020
    Status:
    Published
  2. Ocena wpływu syntetycznego liganda dla receptora formylowego 2 (FPR2) na poziom dehydrogenazy mleczanowej w hodowlach pierwotnych mikrogleju
    Authors:
    Chamera K., Leśkiewicz M., Regulska M., Lacivita E, Leopoldo M, Basta-Kaim A.
    Conference:
    XIII Interdyscyplinarna Konferencja Naukowa "Interdyscyplinarność kluczem do rozwoju" (rok: 2021, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 25-28.03.2021
    Status:
    Published
  3. The role of agonists of formyl peptide 2 receptor in LPS-induced production of nitric oxide in organotypic cultures.
    Authors:
    Regulska M., Leśkiewicz M., Trojan E., Leopoldo M., Basta-Kaim A.
    Conference:
    20th International Congress of the Polish Pharmacological Society, 5-7 June 2019, Lublin (rok: 2019, ), Wydawca: Polskie Towarzystwo Farmakologiczne
    Data:
    konferencja 2019-06-05-07
    Status:
    Published
  4. Wyciszanie procesów zapalnych z wykorzystaniem agonistów receptorów formylowych ALX/FPR2 jako nowa strategia terapeutyczna chorób ośrodkowego układu nerwowego
    Authors:
    Ewa Trojan, Kinga Tylek, Monika Leśkiewicz, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
    Conference:
    II Ogólnopolska Konferencja Naukowa "Nauki przyrodnicze na rzecz człowieka i środowiska" (rok: 2020, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 27.10.2020
    Status:
    Published
  5. Emerging role of a new ureidopropanamide formyl peptide receptor 2 agonist in the modulation of pro- and anti-inflammatory cytokine signaling pathways in organotypic hippocampal cultures stimulated by lipopolysaccharide.
    Authors:
    Tylek K., Trojan E., Lacivita E., Leopoldo M., Leśkiewicz M., Basta-Kaim A.
    Conference:
    International Forum on Neuroscience and Brain Disorders (rok: 2023, ), Wydawca: NEUROFORUM2023
    Data:
    konferencja 13-15.04.2023
    Status:
    Accepted for publication
  6. Pro-resolving FPR2 agonists regulate necrotic and apoptotic cell death in the lipopolysaccharide stimulated primary microglia cultures: link to neuroprotection
    Authors:
    Trojan E., Tylek K., Leśkiewicz M., Regulska M., Korzeniak B., Lacivita E, Leopoldo M, Basta-Kaim A.
    Conference:
    4th Central European Biomedical Congress (CEBC) (rok: 2021, ), Wydawca: Instytut Farmakologii im. Jerzego Maja PAN i Uniwersytet Jagielloński
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  7. Rola agonisty receptora formylowego 2 w modulacji efektów przeciwzapalnych w hodowlach organotypowych hipokampa indukowanych lipopolisacharydem
    Authors:
    Kinga Tylek, Monika Leśkiewicz, Ewa Trojan, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
    Conference:
    II Ogólnopolska Konferencja Naukowa "Nauki przyrodnicze na rzecz człowieka i środowiska" (rok: 2020, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 27.20.2020
    Status:
    Published
  8. Protective and pro-resolving impact of the formyl peptide receptor 2 treatment in the lipopolysaccharide-exposed primary microglia cells.
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Regulska M., Lacivita E., Leopoldo M., Basta-Kaim A.
    Conference:
    FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: Polish Neuroscience Society
    Data:
    konferencja 2021-08-25-27
    Status:
    Published
  9. The protective properties of new agonists of FPR2 on the evoked by bacterial endotoxin changes in microglia cells.
    Authors:
    Basta-Kaim A., Leśkiewicz M., Regulska M., Trojan E., Lacivita E., Leopoldo M.
    Conference:
    The 19th WPA World Congress of Psychiatry, 21-24 August 2019 - Lisbon, Portugal (rok: 2019, ), Wydawca: The Congress Scientific Committee
    Data:
    konferencja 2019-08-21-24
    Status:
    Published
  10. Formyl peptide receptor 2 (FPR2) on microglia cells as a new target for therapeutic approach to neuroinflammation-based brain disorders
    Authors:
    Tylek K., Leśkiewicz M., Trojan E., Lacivita E., Leopoldo M., Basta-Kaim A.
    Conference:
    International Forum on Neuroscience and Brain Disorders (rok: 2023, ), Wydawca: NEUROFORUM2023
    Data:
    konferencja 13-15.04.2023
    Status:
    Accepted for publication
  11. Prenatal stress sensitizes microglia cells to lipopolysaccharide-induced inflammatory response: link to the impact of the FPR2 activation
    Authors:
    Kamińska K, Regulska M, Leśkiewicz M, Trojan E, Tylek K, Curzytek K, Lacivita E, Leopoldo M, Basta-Kaim A
    Conference:
    NEURONUS 2022, 12th Neuronus Neuroscience Forum (rok: 2022, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 15-17.10.2022
    Status:
    Published
  12. The impact of novel synthetic FPR2 ligands on the prenatal stress-induced activity of primary microglial cells
    Authors:
    Leśkiewicz M, Regulska M, Trojan E, Tylek K, Curzytek K, Korzeniak B, Kaim K, Lacivita E, Leopoldo M, Basta-Kaim A
    Conference:
    35th ECNP Congress (rok: 2022, ), Wydawca: ECNP
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
  13. The neuroprotective effect of lipoxin A4 on the LPS-induced cell death in microglia cells.
    Authors:
    Leśkiewicz M., Regulska M., Trojan E., Lacivita E., Leopoldo M., Basta-Kaim A.
    Conference:
    20th International Congress of the Polish Pharmacological Society, 5-7 June 2019, Lublin (rok: 2019, ), Wydawca: Polskie Towarzystwo Farmakologiczne
    Data:
    konferencja 2019-06-05-07
    Status:
    Published

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