Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic strategy of depression.

2017/26/M/NZ7/01048

Keywords:

peptide formyl receptor 2 (ALX/FPR2) new ureidopropanamide agonist ALX/FPR2 resolution of inflammation depression

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_12: Prevention of human diseases
  • NZ3_6: Cell neurobiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Basta-Kaim 

Number of co-investigators in the project: 6

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 238 986 PLN

Project start date (Y-m-d): 2018-05-24

Project end date (Y-m-d): 2023-05-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (13)
  1. The Contribution of Formyl Peptide Receptor Dysfunction to the Course of Neuroinflammation: A Potential Role in the Brain Pathology.
    Authors:
    Trojan E., Bryniarska N., Leśkiewicz M., Regulska M., Chamera K., Szuster-Głuszczak M., Leopoldo M., Lancivita E., Basta-Kaim A.
    Academic press:
    Current Neuropharmacology (rok: 2020, tom: 18, strony: 229-249), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X17666191019170244 - link to the publication
  2. The Emerging Role of the Double-Edged Impact of Arachidonic Acid- Derived Eicosanoids in the Neuroinflammatory Background of Depression.
    Authors:
    Regulska M., Szuster-Głuszczak M., Trojan E., Leśkiewicz M., Basta-Kaim A.
    Academic press:
    Current Neuropharmacology (rok: 2021, tom: 19, strony: 278-293), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X18666200807144530 - link to the publication
  3. The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures.
    Authors:
    Trojan E., Tylek K., Leśkiewicz M., Lasoń W, Brandenburg L.O., Leopoldo M., Lacivita E., Basta-Kaim A.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 1524), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10061524 - link to the publication
  4. Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Francavilla F., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    ACS Chemical Neuroscience (rok: 2023, tom: 14, strony: 3869-3882), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acschemneuro.3c00525 - link to the publication
  5. The Formyl Peptide Receptor 2 as a Target for Promotion of Resolution of Inflammation
    Authors:
    Trojan E., Leśkiewicz M., Lacivita E., LeopoldoM., Basta-Kaim A.
    Academic press:
    Current Neuropharmacology (rok: 2022, tom: Sep. 13, strony: 45297), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X20666220913155248 - link to the publication
  6. The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1-42)-Induced Neuroinflammation in Mouse Models of Alzheimer's Disease
    Authors:
    Trojan E., Tylek K., Schroder N., Kahl I., Brandenburg LO., Mastromarino M., Leopoldo M., Basta-Kaim A., Lacivita E.
    Academic press:
    Molecular neurobiology (rok: 2021, tom: 8, strony: 6203-6221), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-021-02543-2 - link to the publication
  7. Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study 4 of Organotypic Hippocampal Cultures
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Ghafir El Idrissi I., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 45316), Wydawca: MDPI
    Status:
    Accepted for publication
    DOI:
    10.3390/xxxxx - link to the publication
  8. The Potential Role of Dysfunctions in Neuron-Microglia Communication in the Pathogenesis of Brain Disorders
    Authors:
    Katarzyna Chamera, Ewa Trojan, Magdalena Szuster-Głuszczak, Agnieszka Basta-Kaim
    Academic press:
    Current Neuropharmacology (rok: 2020, tom: 18, strony: 408-430), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1570159X17666191113101629 - link to the publication
  9. Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders
    Authors:
    Mastromarino M., Favia M., Schepetkin I.A., Kirpotina L.N., Trojan E., Niso M., Carrieri A., Leśkiewicz M., Regulska M., Darida M., Rossignolo F., Fontana S., Quinn M.T., Basta-Kaim A., Leopoldo M., Lacivita E.
    Academic press:
    Journal of Medicinal Chemistry (rok: 2022, tom: 65, strony: 5004-5028), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.1c02203 - link to the publication
  10. Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology.
    Authors:
    Tylek K., Trojan E., Regulska M., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    Pharmacological Reports (rok: 2021, tom: 73, strony: 1004-1019), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00271-x - link to the publication
  11. Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways.
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Regulska M., Bryniarska N., Curzytek K., Lacivita E., Leopoldo M., Basta-Kaim A.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 2373), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10092373 - link to the publication
  1. Development of new drug-like FPR2 agonist with anti-inflammatory properties: study in the in vitro model of neuroinflammation
    Authors:
    Kinga Tylek, Monika Leśkiewicz, Ewa Trojan, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
    Conference:
    NEURONUS 2020 IBRO NEUROSCIENCE FORUM (rok: 2020, ), Wydawca: Uniwersytet Jagielloński
    Data:
    konferencja 8.12-11.12.2020
    Status:
    Published
  2. Ocena wpływu syntetycznego liganda dla receptora formylowego 2 (FPR2) na poziom dehydrogenazy mleczanowej w hodowlach pierwotnych mikrogleju
    Authors:
    Chamera K., Leśkiewicz M., Regulska M., Lacivita E, Leopoldo M, Basta-Kaim A.
    Conference:
    XIII Interdyscyplinarna Konferencja Naukowa "Interdyscyplinarność kluczem do rozwoju" (rok: 2021, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 25-28.03.2021
    Status:
    Published
  3. Pro-resolving FPR2 agonists regulate necrotic and apoptotic cell death in the lipopolysaccharide stimulated primary microglia cultures: link to neuroprotection
    Authors:
    Trojan E., Tylek K., Leśkiewicz M., Regulska M., Korzeniak B., Lacivita E, Leopoldo M, Basta-Kaim A.
    Conference:
    4th Central European Biomedical Congress (CEBC) (rok: 2021, ), Wydawca: Instytut Farmakologii im. Jerzego Maja PAN i Uniwersytet Jagielloński
    Data:
    konferencja 7-9.06.2021
    Status:
    Published
  4. The neuroprotective effect of lipoxin A4 on the LPS-induced cell death in microglia cells.
    Authors:
    Leśkiewicz M., Regulska M., Trojan E., Lacivita E., Leopoldo M., Basta-Kaim A.
    Conference:
    20th International Congress of the Polish Pharmacological Society, 5-7 June 2019, Lublin (rok: 2019, ), Wydawca: Polskie Towarzystwo Farmakologiczne
    Data:
    konferencja 2019-06-05-07
    Status:
    Published
  5. Formyl peptide receptor 2 (FPR2) on microglia cells as a new target for therapeutic approach to neuroinflammation-based brain disorders
    Authors:
    Tylek K., Leśkiewicz M., Trojan E., Lacivita E., Leopoldo M., Basta-Kaim A.
    Conference:
    International Forum on Neuroscience and Brain Disorders (rok: 2023, ), Wydawca: NEUROFORUM2023
    Data:
    konferencja 13-15.04.2023
    Status:
    Accepted for publication
  6. Prenatal stress sensitizes microglia cells to lipopolysaccharide-induced inflammatory response: link to the impact of the FPR2 activation
    Authors:
    Kamińska K, Regulska M, Leśkiewicz M, Trojan E, Tylek K, Curzytek K, Lacivita E, Leopoldo M, Basta-Kaim A
    Conference:
    NEURONUS 2022, 12th Neuronus Neuroscience Forum (rok: 2022, ), Wydawca: Nencki Institute of Experimental Biology
    Data:
    konferencja 15-17.10.2022
    Status:
    Published
  7. Protective and pro-resolving impact of the formyl peptide receptor 2 treatment in the lipopolysaccharide-exposed primary microglia cells.
    Authors:
    Tylek K., Trojan E., Leśkiewicz M., Regulska M., Lacivita E., Leopoldo M., Basta-Kaim A.
    Conference:
    FENS Regional Meeting 2021 (rok: 2021, ), Wydawca: Polish Neuroscience Society
    Data:
    konferencja 2021-08-25-27
    Status:
    Published
  8. The protective properties of new agonists of FPR2 on the evoked by bacterial endotoxin changes in microglia cells.
    Authors:
    Basta-Kaim A., Leśkiewicz M., Regulska M., Trojan E., Lacivita E., Leopoldo M.
    Conference:
    The 19th WPA World Congress of Psychiatry, 21-24 August 2019 - Lisbon, Portugal (rok: 2019, ), Wydawca: The Congress Scientific Committee
    Data:
    konferencja 2019-08-21-24
    Status:
    Published
  9. Wyciszanie procesów zapalnych z wykorzystaniem agonistów receptorów formylowych ALX/FPR2 jako nowa strategia terapeutyczna chorób ośrodkowego układu nerwowego
    Authors:
    Ewa Trojan, Kinga Tylek, Monika Leśkiewicz, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
    Conference:
    II Ogólnopolska Konferencja Naukowa "Nauki przyrodnicze na rzecz człowieka i środowiska" (rok: 2020, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 27.10.2020
    Status:
    Published
  10. Emerging role of a new ureidopropanamide formyl peptide receptor 2 agonist in the modulation of pro- and anti-inflammatory cytokine signaling pathways in organotypic hippocampal cultures stimulated by lipopolysaccharide.
    Authors:
    Tylek K., Trojan E., Lacivita E., Leopoldo M., Leśkiewicz M., Basta-Kaim A.
    Conference:
    International Forum on Neuroscience and Brain Disorders (rok: 2023, ), Wydawca: NEUROFORUM2023
    Data:
    konferencja 13-15.04.2023
    Status:
    Accepted for publication
  11. The impact of novel synthetic FPR2 ligands on the prenatal stress-induced activity of primary microglial cells
    Authors:
    Leśkiewicz M, Regulska M, Trojan E, Tylek K, Curzytek K, Korzeniak B, Kaim K, Lacivita E, Leopoldo M, Basta-Kaim A
    Conference:
    35th ECNP Congress (rok: 2022, ), Wydawca: ECNP
    Data:
    konferencja 15-18.10.2022
    Status:
    Published
  12. The role of agonists of formyl peptide 2 receptor in LPS-induced production of nitric oxide in organotypic cultures.
    Authors:
    Regulska M., Leśkiewicz M., Trojan E., Leopoldo M., Basta-Kaim A.
    Conference:
    20th International Congress of the Polish Pharmacological Society, 5-7 June 2019, Lublin (rok: 2019, ), Wydawca: Polskie Towarzystwo Farmakologiczne
    Data:
    konferencja 2019-06-05-07
    Status:
    Published
  13. Rola agonisty receptora formylowego 2 w modulacji efektów przeciwzapalnych w hodowlach organotypowych hipokampa indukowanych lipopolisacharydem
    Authors:
    Kinga Tylek, Monika Leśkiewicz, Ewa Trojan, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
    Conference:
    II Ogólnopolska Konferencja Naukowa "Nauki przyrodnicze na rzecz człowieka i środowiska" (rok: 2020, ), Wydawca: Fundacja na rzecz promocji nauki i rozwoju TYGIEL
    Data:
    konferencja 27.20.2020
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy