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Information of the project and the call

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Antimicrobial peptide - metal interactions - understanding the correlation between coordination chemistry, structure, thermodynamics and mode of action

2017/26/E/ST5/00364

Keywords:

bioinorganic chemistry antimicrobial peptides thermodynamics coordination modes

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:
  • ST5_24:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Rowińska-Żyrek 

Number of co-investigators in the project: 11

Call: SONATA BIS 7 - announced on 2017-06-14

Amount awarded: 1 857 900 PLN

Project start date (Y-m-d): 2018-11-13

Project end date (Y-m-d): 2024-11-12

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (30)
  • Articles in post-conference publications (1)
  1. Peptidomimetics – An infinite reservoir of metal binding motifs in metabolically stable and biologically active molecules
    Authors:
    Wątły Joanna, Miller Adriana, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2021, tom: 217, strony: 111386), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2021.111386 - link to the publication
  2. Thermodynamic surprises of Cu(II)-amylin analogue complexes in membrane mimicking solutions
    Authors:
    Dzień Emilia, Dudek Dorota, Witkowska Danuta, Rowińska-Żyrek Magdalena
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 425/1-425/9), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-021-04197-5 - link to the publication
  3. Zn(II)-alloferon complexes - similar sequence, different coordination modes, no antibacterial activity
    Authors:
    Dudek Dorota, Miller Adriana, Draghi Sara, Valensin Daniela, Mikołajczyk Aleksandra, Matera-Witkiewicz Agnieszka, Witkowska Danuta, Stokowa-Sołtys Kamila, Rowińska-Żyrek Magdalena
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2020, tom: 213, strony: 111275/1-111275/9), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2020.111275 - link to the publication
  4. Copper(II)-binding induces a unique polyproline type II helical structure within the ion-binding segment in the intrinsically disordered F-domain of ecdysteroid receptor from Aedes aegypti
    Authors:
    Rowińska-Żyrek Magdalena, Więch Anna, Wątły Joanna, Wieczorek Robert, Witkowska Danuta, Ożyhar Andrzej, Orłowski Marek
    Academic press:
    Inorganic Chemistry (rok: 2019, tom: 58, strony: 11782-11792), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b01826 - link to the publication
  5. Metal complexes of two specific regions of ZnuA, a periplasmic zinc(II) transporter from Escherichia coli
    Authors:
    Hecel Aleksandra, Kola Arian, Valensin Daniela, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry (rok: 2020, tom: 59, strony: 1947-1958), Wydawca: ASC
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b03298 - link to the publication
  6. Uncapping the N-terminus of a ubiquitous His-tag peptide enhances its Cu2+ binding affinity
    Authors:
    Wątły Joanna, Hecel Aleksandra, Wieczorek Robert, Świątek-Kozłowska Jolanta, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2019, tom: 48, strony: 13567-13579), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c9dt01635j - link to the publication
  7. Zn(II) binding to pramlintide results in a structural kink, fibril formation and antifungal activity
    Authors:
    Dudek Dorota, Dzień Emilia, Wątły Joanna, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Hajda Agata, Olesiak-Bańska Joanna, Rowińska-Żyrek Magdalena
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 20543/1-20543/8), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-24968-y - link to the publication
  8. Aspergillus fumigatus ZrfC Zn(II) transporter scavengers zincophore-bound Zn(II)
    Authors:
    Garstka Kinga, Potoczniak Gabriela, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2024, tom: 53, strony: 2848-2858), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d3dt04083f - link to the publication
  9. Copper(II) and amylin analogues: a complicated relationship
    Authors:
    Alghrably Mawadda, Dudek Dorota, Emwas Abdul-Hamid, Jaremko Łukasz, Jaremko Mariusz, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry (rok: 2020, tom: 59, strony: 2527-2535), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b03498 - link to the publication
  10. Copper(II)-induced restructuring of ZnuD, a Zinc(II) transporter from Neisseria meningitidis.
    Authors:
    Hecel Aleksandra, Rowińska-Żyrek Magdalena, Kozłowski Henryk
    Academic press:
    Inorganic Chemistry (rok: 2019, tom: 58, strony: 5932-5942), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.9b00265 - link to the publication
  11. Pneumococcal HxxHxH triad - Copper(II) interactions - How important is the 'x'?
    Authors:
    Potocki Sławomir, Delgado Paula, Dudek Dorota, Janicka-Kłos Anna, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganica Chimica Acta (rok: 2019, tom: 488, strony: 255-259), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2019.01.029 - link to the publication
  12. Zinc(II)—the overlooked éminence grise of chloroquine's fight against COVID-19?
    Authors:
    Hecel Aleksandra, Ostrowska Małgorzata, Stokowa-Sołtys Kamila, Wątły Joanna, Dudek Dorota, Miller Adriana, Potocki Sławomir, Matera-Witkiewicz Agnieszka, Domínguez-Martín Alicia, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Pharmaceuticals (rok: 2020, tom: 13, strony: 228/1-228/29), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ph13090228 - link to the publication
  13. Zn-enhanced Asp-rich antimicrobial peptides: N-terminal coordination by Zn(II) and Cu(II), which distinguishes Cu(II) binding to different peptides
    Authors:
    Miller Adriana, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Wątły Joanna, Wilcox Dean, Witkowska Danuta, Rowińska-Żyrek Magdalena
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 6971/1-6971/20), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22136971 - link to the publication
  14. Bioinorganic chemistry of calcitermin – the picklock of its antimicrobial activity
    Authors:
    Bellotti Denise, Toniolo Mattia, Dudek Dorota, Mikołajczyk Aleksandra, Guerrini Remo, Matera-Witkiewicz Agnieszka, Remelli Maurizio, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2019, tom: 48, strony: 13740-13752), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/c9dt02869b - link to the publication
  15. Bioinorganic chemistry of shepherin II complexes helps to fight Candida albicans?
    Authors:
    Szarszoń Klaudia, Mikołajczyk Aleksandra, Grelich-Mucha Manuela, Wieczorek Robert, Matera-Witkiewicz Agnieszka, Olesiak-Bańska Joanna, Rowińska-Żyrek Magdalena, Wątły Joanna
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2024, tom: 253, strony: 112476/1-112476/10), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2023.112476 - link to the publication
  16. Chemical butterfly effect" explaining the coordination chemistry and antimicrobial properties of clavanin complexes
    Authors:
    Miller Adriana, Matera-Witkiewicz Agnieszka, Mikołajczyk Aleksandra, Wieczorek Robert, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry (rok: 2021, tom: 60, strony: 12730-12734), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.1c02101 - link to the publication
  17. How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores
    Authors:
    Bellotti Denise, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Current Medicinal Chemistry (rok: 2021, tom: 28, strony: 7312-7338), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1389200222666210514012945 - link to the publication
  18. Metal coordination to solute binding proteins – exciting chemistry with potential biological meaning
    Authors:
    Garstka Kinga, Bellotti Denise, Wątły Joanna, Kozłowski Henryk, Remelli Maurizio, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2023, tom: 52, strony: 16140-16150), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/D3DT02417B - link to the publication
  19. Novel insights into the metal binding ability of ZinT periplasmic protein from Escherichia coli and Salmonella enterica
    Authors:
    Bellotti Denise, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Dalton Transactions (rok: 2020, tom: 49, strony: 9393-9403), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d0dt01626h - link to the publication
  20. Semenogelins Armed in Zn(II) and Cu(II): May Bioinorganic Chemistry Help Nature to Cope with Enterococcus faecalis?
    Authors:
    Dudek Dorota, Miller Adriana, Hecel Aleksandra, Kola Arian, Valensin Daniela, Mikołajczyk Aleksandra, Barceló-Oliver Miquel, Matera-Witkiewicz Agnieszka, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry, (rok: 2023, tom: 62, strony: 14103-14115), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.3c02390 - link to the publication
  21. Specific Zn(II)-binding site in the C-terminus of Aspf2, a zincophore from Aspergillus fumigatus
    Authors:
    Garstka Kinga, Hecel Aleksandra, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Metallomics (rok: 2022, tom: 14, strony: mfac042), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/mtomcs/mfac042 - link to the publication
  22. The N-terminal domain of Helicobacter pylori's Hpn protein: The role of multiple histidine residues
    Authors:
    Bellotti Denise, Sinigaglia Angelica, Guerrini Remo, Marzola Erika, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2020, tom: 214, strony: 111304/1-111304/12), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2020.111304 - link to the publication
  23. Thermodynamic and spectroscopic study of Cu(II) and Zn(II) complexes with the (148–156) peptide fragment of C4YJH2, a putative metal transporter of Candida albicans
    Authors:
    Bellotti Denise, Tocchio Cinzia, Guerrini Remo, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Metallomics (rok: 2019, tom: 11, strony: 1988-1998), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/C9MT00251K - link to the publication
  24. Biophysical approaches for the study of metal-protein interactions
    Authors:
    Witkowska Danuta, Rowińska-Żyrek Magdalena
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2019, tom: 199, strony: 110783/1-110783/10), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.110783 - link to the publication
  25. CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
    Authors:
    Garstka Kinga, Dzyhovskyi Valentyn, Wątły Joanna, Stokowa-Sołtys Kamila, Świątek-Kozłowska Jolanta, Kozłowski Henryk, Barceló-Oliver Miquel, Bellotti Denise, Rowińska-Żyrek Magdalena
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 3985/1-3985/14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28103985 - link to the publication
  26. Metal specificity of the Ni(II) and Zn(II) binding sites of the N-terminal and G-domain of E. coli HypB
    Authors:
    Hecel Aleksandra, Kola Arian, Valensin Daniela, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Dalton Transactions (rok: 2021, tom: 50, strony: 12635-12647), Wydawca: RSC
    Status:
    Published
    DOI:
    10.1039/d1dt02126e - link to the publication
  27. Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides
    Authors:
    Wątły Joanna, Hecel Aleksandra, Wieczorek Robert, Rowińska-Żyrek Magdalena, Kozłowski Henryk
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, strony: 14247-14251), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c02584 - link to the publication
  28. Zn(II) Induces Fibril Formation and Antifungal Activity in Shepherin I, An Antimicrobial Peptide from Capsella bursa-pastoris
    Authors:
    Wątły Joanna, Szarszoń Klaudia, Mikołajczyk Aleksandra, Grelich-Mucha Manuela, Matera-Witkiewicz Agnieszka, Olesiak-Bańska Joanna, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry (rok: 2023, tom: 62, strony: 19786-19794), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.3c03409 - link to the publication
  29. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter of Candida albicans
    Authors:
    Bellotti Denise, Miller Adriana, Rowińska-Żyrek Magdalena, Remelli Maurizio
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 121/1-121/16), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12010121 - link to the publication
  30. –HH and –HAAAH motifs act as fishing nets for biologically relevant metal ions in metallopeptides
    Authors:
    Hecel Aleksandra, Garstka Kinga, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2024, tom: 252, strony: 112456/1-112456/14), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2023.112456 - link to the publication
  1. Antimicrobial Peptide – Metal Interactions – Relationship between Coordination Chemistry, Structure, Thermodynamics and Mode of Action
    Authors:
    Magdalena Rowińska-Żyrek, Dorota Dudek, Denise Belotti, Adriana Miller, Aleksandra Mikołajczyk, Agnieszka Matera-Witkiewicz
    Conference:
    19th International Conference on Biological Inorganic Chemistry (rok: 2019, ), Wydawca: organizatorzy: Eva Freisinger, Roland Sigel, Wydział Chemii Uniwersytetu w Zurychu
    Data:
    konferencja 11-16.08.2019
    Status:
    Published

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