Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Characterization of Trypanosoma cruzi PEX5 as a promising target in Chagas disease

2017/26/M/NZ1/00797

Keywords:

Chagas disease Trypanosoma cruzi

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_2: Biochemistry
  • NZ1_10: Microbiology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grzegorz Dubin 

Number of co-investigators in the project: 6

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 478 260 PLN

Project start date (Y-m-d): 2018-04-27

Project end date (Y-m-d): 2022-04-26

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations
    Authors:
    Sonani RR, Blat A, Dubin G
    Academic press:
    International Journal of Biological Macromolecules (rok: 2022, tom: 205, strony: 203-210), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2022.02.008 - link to the publication
  2. Small Molecule Mediated Inhibition of Protein Cargo Recognition by Peroxisomal Transport Receptor PEX5 Is Toxic to Trypanosoma
    Authors:
    Napolitano V, Softley AC, Blat A, Kalel VC, Schorpp K, Siebenmorgen T,Hadian K, Erdmann R, Sattler M, Popowicz GM, Dubin G
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 14705), Wydawca: Nature Research
    Status:
    Published
    DOI:
    10.1038/s41598-022-18841-1 - link to the publication
  3. Water envelope has a critical impact on the design of protein–protein interaction inhibitors
    Authors:
    Ratkova, EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV
    Academic press:
    Chemical Communications (rok: 2020, tom: 56, strony: 4360-4363), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9cc07714f - link to the publication
  4. Structural dynamics of Pex5 peroxisomal cargo receptor in Trypanosoma
    Authors:
    Banasik M, Napolitano V, Abdulkarim K, Plewka J, Blat A, Czaplewski C, Gieldon A, Kozak M, Wladyka B, Popowicz G, Dubin G
    Academic press:
    Journal of Molecular Biology (rok: 2022, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity
    Authors:
    Dawidowski M, Kalel VC, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Maser P, Tetko I, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz GM.
    Academic press:
    Journal of Medicinal Chemistry (rok: 2020, tom: 63, strony: 847-879), Wydawca: American Chemical Society Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.9b01876 - link to the publication
  6. Distinct sequence and structural feature of trypanosoma malate dehydrogenase
    Authors:
    Sonani RR, Kurpiewska K, Lewinski K, Dubin G
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2021, tom: 557, strony: 288-293), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2021.04.033 - link to the publication
  7. Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma
    Authors:
    Napolitano V, Mróz P, Marciniak M, Kalel VC, Softley C, Olmos JDJ, Tippler BG, Schorpp K, Rioton S, Froehlich T, Plattenburg O, Hadian K, Erdmann R, Sattler M, Popowicz GM, Dawidowski M, Dubin G
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2022, tom: 243, strony: 114778), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2022.114778 - link to the publication

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