Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Influence of hydration water properties on the process of amyloid fibrils formation

2017/26/D/NZ1/00497

Keywords:

Amyloids Hydration Osmolytes FTIR Spectroscopy Circular dichroism Fluorescence spectroscopy Atomic force microscopy Computer simulation

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_3: Biophysics
  • ST4_13: Solid-state chemistry, surface physicochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Bruździak 

Number of co-investigators in the project: 8

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 712 500 PLN

Project start date (Y-m-d): 2018-04-10

Project end date (Y-m-d): 2022-04-09

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Liofilizator laboratoryjny (75 000 PLN)
  2. Stacja robocza PC (2 665 PLN)
  3. Generator suchego azotu do spektrometru FTIR (64 501 PLN)
  4. Stacje robocze PC (2 szt.) (8 000 PLN)
  5. Łaźnia ultradźwiękowa z funkcją odgazowywania z niezbędnymi akcesoriami (6 000 PLN)
  6. Łaźnia wodna z wytrząsaniem (18 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Hydration of Simple Model Peptides in Aqueous Osmolyte Solutions
    Authors:
    A. Panuszko, M. Pieloszczyk, A. Kuffel, K. Jacek, K. A. Biernacki, S. Demkowicz, J. Stangret, P. Bruździak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 9350), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22179350 - link to the publication
  2. Interactions in Ternary Aqueous Solutions of NMA and Osmolytes—PARAFAC Decomposition of FTIR Spectra Series
    Authors:
    E. Kaczkowska, A. Panuszko, P. Bruździak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11684), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111684 - link to the publication
  3. DMSO and TMAO—Differences in Interactions in Aqueous Solutions of the K-Peptide
    Authors:
    J. Godlewska, B. Cieśla, J. Wawer, P. Bruździak
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1872), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031872 - link to the publication
  4. Amides as models to study the hydration of proteins and peptides - spectroscopic and theoretical approach on hydration in various temperatures
    Authors:
    A.Panuszko, M.G.Nowak, P.Bruździak, M.Stasiulewicz, J.Stangret
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 278, strony: 706-715), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2019.01.086 - link to the publication
  5. Mechanism of Osmolyte Stabilization–Destabilization of Proteins: Experimental Evidence
    Authors:
    M. Stasiulewicz, A. Panuszko, P. Bruździak, J. Stangret
    Academic press:
    Journal of Physical Chemistry B (rok: 2022, tom: 126, strony: 2990-2999), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.2c00281 - link to the publication
  6. Influence of Urea and Dimethyl Sulfoxide on K-Peptide Fibrillation
    Authors:
    J. Wawer , J. Karczewski , R. Aranowski, R. Piątek, D. Augustin-Nowacka, P. Bruździak
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 3027), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23063027 - link to the publication
  7. Interactions between hydration spheres of two different solutes in solution: The least squares fitting with constraints as a tool to determine water properties in ternary systems.
    Authors:
    A. Panuszko, J. Stangret, B. Nowosielski, P. Bruździak
    Academic press:
    Journal of Molecular Liquids (rok: 2020, tom: 310, strony: 113181), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2020.113181 - link to the publication
  8. Vapor correction of FTIR spectra – A simple automatic least squares approach
    Authors:
    P. Bruździak
    Academic press:
    Spectrochimica Acta Part A (rok: 2019, tom: 223, strony: 117373), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2019.117373 - link to the publication

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