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Tetrapertite inhibitory synapse - the role of extracellular matrix, adhesion proteins and astrocytes in the plasticity of GABAergic synapses

2017/26/D/NZ4/00450

Keywords

Descriptors

  • NZ4_7: Neurofizjologia
  • NZ4_9: Neurobiologia systemowa
  • NZ3_6: Neurobiologia komórkowa

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Grzegorz Tadeusz Wiera

Number of co-investigators in the project: 5

Call

SONATA 13 – announced on 2017-06-14

Amount awarded
1 163 400 PLN
Project start date
2018-04-09
Project end date
2023-01-08
Project duration
57 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer z dwoma monitorami. Cost: 5 000 PLN
  2. system do uwalniania neuroprzekażnika za pomocą lasera UV. Cost: 240 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses

    Authors:
    Grzegorz Wiera, Jerzy Mozrzymas
    Academic press:
    Cells (year: 2021, volume: 10(8), pages: 2055), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10082055. – link to the publication

  2. Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity

    Authors:
    Grzegorz Wiera, Patrycja Brzdąk, Anna Maria Lech, Katarzyna Lebida, Jadwiga Jabłońska, Przemysław Gmerek and Jerzy W. Mozrzymas
    Academic press:
    Journal of Neuroscience (year: 2022, volume: 42 (30), pages: 5830-5842), Publisher: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.1458-21.2022 – link to the publication

  3. Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3

    Authors:
    Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdąk, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W Mozrzymas
    Academic press:
    Cellular and Molecular Life Sciences (year: 2021, volume: 78(5), pages: 2279-2298), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-020-03640-6 – link to the publication

  4. Matrix metalloproteinase-3 in brain physiology and neurodegeneration.

    Authors:
    Lech A, Wiera G, Mozrzymas JW
    Academic press:
    Advances in Clinical and Experimental Medicine (year: 2019, volume: 28(12), pages: 1717-1722), Publisher: Wroclaw Medical University
    Status:
    Published
    DOI:
    10.17219/acem/110319 – link to the publication

Articles in post-conference publications (5)

  1. GABAergic hippocampal plasticity critically depends on matrix metalloproteinase 3

    Authors:
    Mozrzymas J.W. ,Brzdak P. ,Lebida K. ,Lech A. ,Wiera G.
    Conference:
    14th congress of the Polish Neuroscience Society (year: 2019, pages: Suppl.1 str. 33-34), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 2019-08-28-30
    Status:
    Published

  2. GABAergic plasticity in hippocampus depends on the activity of matrix metalloprotease‑3

    Authors:
    Lech A. , Buszka A. , Mozrzymas J.W. , Wiera G.
    Conference:
    14th congress of the Polish Neuroscience Society (year: 2019, pages: Suppl.1 p LXVII str. 68-69), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 2019-08-28-30
    Status:
    Published

  3. Matrix metalloproteinase 3 critically affects postsynaptic long-term potentiation at GABAergic synapses in the mouse hippocampal CA1 region

    Authors:
    Brzdak P. , Lebida K. , Mozrzymas J.W.
    Conference:
    14th congress of the Polish Neuroscience Society (year: 2019, pages: Suppl.1 p LXIII str. 63), Publisher: Acta Neurobiologiae Experimentalis
    Date:
    conference 2019-08-28-30
    Status:
    Published

  4. Activation of integrin β3 mediates the induction of long-term depression at inhibitory synapses between parvalbumin interneurons and pyramidal cells in hippocampus.

    Authors:
    Wiera G, Jabłońska J, Lech A, Gmerek P, Mozrzymas JW
    Conference:
    FENS Regional Meeting (year: 2021, pages: 302), Publisher: FENS
    Date:
    conference 25-27.08.2021
    Status:
    Published

  5. Neuroligin-2 regulates long-term GABAergic plasticity

    Authors:
    Lech A, Wiera G, Mozrzymas JW
    Conference:
    FENS Regional Meeting (year: 2021, pages: 193-194), Publisher: FENS
    Date:
    conference 25-27.08.2021
    Status:
    Published

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