Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Tetrapertite inhibitory synapse - the role of extracellular matrix, adhesion proteins and astrocytes in the plasticity of GABAergic synapses

2017/26/D/NZ4/00450

Keywords:

inhibitory synapse GABA extracellular matrix astrocyte synaptic plasticity learning

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology
  • NZ3_6: Cell neurobiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Grzegorz Wiera 

Number of co-investigators in the project: 5

Call: SONATA 13 - announced on 2017-06-14

Amount awarded: 1 163 400 PLN

Project start date (Y-m-d): 2018-04-09

Project end date (Y-m-d): 2023-01-08

Project duration:: 57 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. komputer z dwoma monitorami (5 000 PLN)
  2. system do uwalniania neuroprzekażnika za pomocą lasera UV (240 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (5)
  1. Extracellular Metalloproteinases in the Plasticity of Excitatory and Inhibitory Synapses
    Authors:
    Grzegorz Wiera, Jerzy Mozrzymas
    Academic press:
    Cells (rok: 2021, tom: 10(8), strony: 2055), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10082055. - link to the publication
  2. Long-term plasticity of inhibitory synapses in the hippocampus and spatial learning depends on matrix metalloproteinase 3
    Authors:
    Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdąk, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W Mozrzymas
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2021, tom: 78(5), strony: 2279-2298), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-020-03640-6 - link to the publication
  3. Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity
    Authors:
    Grzegorz Wiera, Patrycja Brzdąk, Anna Maria Lech, Katarzyna Lebida, Jadwiga Jabłońska, Przemysław Gmerek and Jerzy W. Mozrzymas
    Academic press:
    Journal of Neuroscience (rok: 2022, tom: 42 (30), strony: 5830-5842), Wydawca: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.1458-21.2022 - link to the publication
  4. Matrix metalloproteinase-3 in brain physiology and neurodegeneration.
    Authors:
    Lech A, Wiera G, Mozrzymas JW
    Academic press:
    Advances in Clinical and Experimental Medicine (rok: 2019, tom: 28(12), strony: 1717-1722), Wydawca: Wroclaw Medical University
    Status:
    Published
    DOI:
    10.17219/acem/110319 - link to the publication
  1. Matrix metalloproteinase 3 critically affects postsynaptic long-term potentiation at GABAergic synapses in the mouse hippocampal CA1 region
    Authors:
    Brzdak P. , Lebida K. , Mozrzymas J.W.
    Conference:
    14th congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 2019-08-28-30
    Status:
    Published
  2. Neuroligin-2 regulates long-term GABAergic plasticity
    Authors:
    Lech A, Wiera G, Mozrzymas JW
    Conference:
    FENS Regional Meeting (rok: 2021, ), Wydawca: FENS
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  3. GABAergic hippocampal plasticity critically depends on matrix metalloproteinase 3
    Authors:
    Mozrzymas J.W. ,Brzdak P. ,Lebida K. ,Lech A. ,Wiera G.
    Conference:
    14th congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 2019-08-28-30
    Status:
    Published
  4. Activation of integrin β3 mediates the induction of long-term depression at inhibitory synapses between parvalbumin interneurons and pyramidal cells in hippocampus.
    Authors:
    Wiera G, Jabłońska J, Lech A, Gmerek P, Mozrzymas JW
    Conference:
    FENS Regional Meeting (rok: 2021, ), Wydawca: FENS
    Data:
    konferencja 25-27.08.2021
    Status:
    Published
  5. GABAergic plasticity in hippocampus depends on the activity of matrix metalloprotease‑3
    Authors:
    Lech A. , Buszka A. , Mozrzymas J.W. , Wiera G.
    Conference:
    14th congress of the Polish Neuroscience Society (rok: 2019, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 2019-08-28-30
    Status:
    Published

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