Projects funded by the NCN
Structural-functional analysis of nucleoprotein complexes of plasmid Rep proteins and ssDNA DUE origin region.
2017/26/D/NZ1/00239
Keywords:
DNA replication initiation DNA replication initiation proteins plasmids
Descriptors:
- NZ1_1: Molecular biology
- NZ1_2: Biochemistry
- NZ1_4: Structural biology
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: SONATA 13 - announced on 2017-06-14
Amount awarded: 833 000 PLN
Project start date (Y-m-d): 2018-04-09
Project end date (Y-m-d): 2022-04-08
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Defining a novel domain which provides an essential contribution to site-specific interaction of Rep protein with DNAAuthors:Wegrzyn Katarzyna; Zabrocka Elzbieta; Bury Katarzyna; Tomiczek Bartlomiej; Wieczor Milosz; Czub Jacek; Uciechowska Urszula; Moreno-Del Alamo Maria; Walkow Urszula; Grochowina Igor; Dutkiewicz Rafal; Bujnicki Janusz M.; Giraldo Rafael; Konieczny IgorAcademic press:Nucleic Acids Research (rok: 2021, tom: 6, strony: 3394–3408), Wydawca: Oxford AcademicStatus:PublishedDOI:10.1093/nar/gkab113 - link to the publication
- Rep protein accommodates together dsDNA and ssDNA which enables a loop-back mechanism to plasmid DNA replication initiation.Authors:Wegrzyn Katarzyna, Oliwa Monika, Nowacka Marzena., Zabrocka Elżbieta, Bury Katarzyna, Purzycki Piotr, Czaplewska Paulina, Pipka Justyna, Giraldo Rafael, Konieczny IgorAcademic press:Nucleic Acids Research (rok: 2023, tom: -, strony: -), Wydawca: Oxford AcademicStatus:PublishedDOI:10.1093/nar/gkad740 - link to the publication
- Toward understanding of the DNA replication initiation in bacteriaAuthors:Wegrzyn Katarzyna, Konieczny IgorAcademic press:Frontiers in Microbiology (rok: 2023, tom: -, strony: -), Wydawca: FrontiersStatus:SubmittedDOI:brak - link to the publication