Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Structure and function of anti-virulent phage origin enzymes active against ESKAPE pathogens

2017/26/M/NZ1/00233

Keywords:

bacteriophages depolymerases proteins structure and function ESKAPE

Descriptors:

  • NZ1_5: Genetic engineering
  • NZ1_4: Structural biology
  • NZ6_5: Virology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Zuzanna Drulis-Kawa 

Number of co-investigators in the project: 6

Call: HARMONIA 9 - announced on 2017-06-14

Amount awarded: 1 474 200 PLN

Project start date (Y-m-d): 2018-04-13

Project end date (Y-m-d): 2023-04-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  1. Engineering the Modular Receptor-Binding Proteins of Klebsiella Phages Switches Their Capsule Serotype Specificity
    Authors:
    Agnieszka Latka, Sebastien Lemire, Dennis Grimon, Dorien Dams, Barbara Maciejewska, Timothy Lu, Zuzanna Drulis-Kawa, Yves Briers
    Academic press:
    mBio (rok: 2021, tom: 12, strony: e00455-21), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/mBio - link to the publication
  2. High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers
    Authors:
    Ouyang R, Costa AR, Cassidy CK, Otwinowska A, Williams VCJ, Latka A, Stansfeld PJ, Drulis-Kawa Z, Briers Y, Pelt DM, Brouns SJJ, Briegel A.
    Academic press:
    Nature Communications (rok: 2022, tom: Nov 24;13(1)., strony: 7241), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41467-022-34972-5 - link to the publication
  3. Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms
    Authors:
    Grazyna Majkowska-Skrobek, Agnieszka Latka, Rita Berisio, Flavia Squeglia, Barbara Maciejewska, Yves Briers, Zuzanna Drulis-Kawa
    Academic press:
    Frontiers in Microbiology (rok: 2018, tom: Volume 9, strony: 2018 Oct 23;9:2517. eCollection 2018.), Wydawca: Frontiers in Microbiology
    Status:
    Published
    DOI:
    10.3389/fmicb.2018.02517 - link to the publication
  4. Modeling the Architecture of Depolymerase-Containing Receptor Binding Proteins in Klebsiella Phages
    Authors:
    Agnieszka Latka, Petr G. Leiman, Zuzanna Drulis-Kawa and Yves Briers
    Academic press:
    Frontiers in Microbiology (rok: 2019, tom: 10, strony: 2649), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2019.02649 - link to the publication
  5. PhREEPred: Phage Resistance Emergence Prediction web to predict bacterial escape from phage cocktail treatment
    Authors:
    Bogna J. Smug, Grazyna Majkowska-Skrobek, Zuzanna Drulis-Kawa
    Academic press:
    Journal of Molecular Biology (rok: 2022, tom: Jul 30;434(14), strony: 167670), Wydawca: Elsevier, Academic Press
    Status:
    Published
    DOI:
    10.1016/j.jmb.2022.167670 - link to the publication
  6. Klebsiella phage KP34gp57 capsular depolymerase structure and function: from a serendipitous finding to the design of active mini-enzymes against K. pneumoniae
    Authors:
    Barbara Maciejewska, Flavia Squeglia, Agnieszka Latka, Mario Privitera, Sebastian Olejniczak, Paulina Switala, Alessia Ruggiero, Daniela Marasco, Eliza Kramarska, Zuzanna Drulis-Kawa, Rita Berisio
    Academic press:
    mBio (rok: 2023, tom: 14, strony: Sep 14;e0132923.), Wydawca: ASM Journals
    Status:
    Published
    DOI:
    10.1128/mbio.01329-23 - link to the publication
  7. Editorial: Bacterial Surface Glycans as the Virulence Agent and the Target for Predators, Therapy, and the Immune System
    Authors:
    Zuzanna Drulis-Kawa
    Academic press:
    Frontiers in Microbiology (rok: 2020, tom: 16, strony: Dec 16;11:624964.), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2020.624964. - link to the publication
  8. Structural and Functional Studies of a Klebsiella Phage Capsule Depolymerase Tailspike: Mechanistic Insights into Capsular Degradation
    Authors:
    Flavia Squeglia, Barbara Maciejewska, Agnieszka Latka, Alessia Ruggiero, Yves Briers, Zuzanna Drulis-Kawa, Rita Berisio
    Academic press:
    Structure (rok: 2020, tom: 28, strony: Jun 2;28(6):613-624.e4.), Wydawca: Cell Press, Elsevier
    Status:
    Published
    DOI:
    10.1016/j.str.2020.04.015 - link to the publication
  9. Targeting biofilms using phages and their enzymes
    Authors:
    Joana Azeredo, Pilar Garcıa, Zuzanna Drulis-Kawa
    Academic press:
    Current Opinion in Biotechnology (rok: 2021, tom: 68, strony: 251–261), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.copbio.2021.02.002 - link to the publication
  10. Isolation and Characterization of the Acadevirus Members BigMira and MidiMira Infecting a Highly Pathogenic Proteus mirabilis Strain
    Authors:
    Jéssica Duarte da Silva, Lene Bens, Adriele J. do Carmo Santos, Rob Lavigne, José Soares, Luís D. R. Melo, Marta Vallino, Roberto Sousa Dias, Zuzanna Drulis-Kawa, Sérgio Oliveira de Paula, Jeroen Wagemans
    Academic press:
    Microorganisms (rok: 2023, tom: 11, strony: 2141), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms11092141 - link to the publication
  11. The Mutation in wbaP cps Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of Klebsiella pneumoniae
    Authors:
    Marta Kaszowska, Grazyna Majkowska-Skrobek, Pawel Markwitz, Cédric Lood, Wojciech Jachymek, Anna Maciejewska, Jolanta Lukasiewicz, Zuzanna Drulis-Kawa
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 11562), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222111562 - link to the publication
  12. Advantages and limitations of microtiter biofilm assays in the model of antibiofilm activity of Klebsiella phage KP34 and its depolymerase
    Authors:
    Agnieszka Latka, Zuzanna Drulis‑Kawa
    Academic press:
    Scientific Reports (rok: 2020, tom: 23, strony: Nov 23;10(1):20338.), Wydawca: Springer-Nature
    Status:
    Published
    DOI:
    10.1038/s41598-020-77198-5 - link to the publication

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