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Information on the principal investigator and host institution

Information of the project and the call

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Multiscale investigations on polymorphism of the beta2-adrenergic receptor: from molecular-scale processes to heart failure therapy.

2017/25/B/NZ7/02654

Keywords:

GPCR polimorphism heart failure

Descriptors:

  • NZ7_14:
  • NZ2_10:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Anita Płazińska 

Number of co-investigators in the project: 8

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 678 800 PLN

Project start date (Y-m-d): 2018-10-01

Project end date (Y-m-d): 2024-03-31

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  • Book publications / chapters in book publications (2)
  1. Evaluation of β-adrenergic ligands for development of pharmacological heart failure and transparency models in zebrafish
    Authors:
    Monika Maciąg, Artur Wnorowski, Kinga Bednarz, Anita Płazińska
    Academic press:
    Toxicology and Applied Pharmacology (rok: 2022, tom: 434, strony: 45680), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.taap.2021.115812 - link to the publication
  2. Chirality Effects in Biomolecular Systems: Calculation of the Relative Free Energies by Molecular Dynamics Simulations
    Authors:
    Anita Plazinska, Wojciech Plazinski
    Academic press:
    Journal of Chemical Information and Modeling (rok: 2020, tom: 60, strony: 5424-5436), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jcim.0c00605 - link to the publication
  3. The Val34Met, Thr164Ile and Ser220Cys polymorphisms of the β2-adrenergic receptor and their consequences on the receptor conformational features: a molecular dynamics simulation study.
    Authors:
    Aneta Archała, Wojciech Płaziński, Anita Płazińska.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 45680), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23105449 - link to the publication
  4. Structural insights into ligand-receptor interactions involved in biased agonism of G-protein coupled receptors.
    Authors:
    Krzysztof Jóźwiak, Anita Płazińska.
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 851-868), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26040851 - link to the publication
  5. Pharmacological assessment of zebrafish-based cardiotoxicity models.
    Authors:
    Monika Maciąg, Artur Wnorowski, Małgorzata Mierzejewska, Anita Płazińska
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2022, tom: 148, strony: 45667), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2022.112695 - link to the publication
  6. A comprehensive pharmacological analysis of fenoterol and its derivatives to unravel the role of β2-adrenergic receptor in zebrafish
    Authors:
    [AUT. KORESP.] Monika Maciąg, [AUT.] Wojciech Płaziński, Wojciech Pulawski, Michał Koliński, Krzysztof Jóźwiak, [AUT. KORESP.] Anita Płazińska
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2023, tom: 160, strony: 45675), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2023.114355 - link to the publication
  7. Unraveling the structural basis of biased agonism in the β2 - adrenergic receptor through molecular dynamics simulations.
    Authors:
    Wojciech Płaziński, Aneta Archała, Krzysztof Jóźwiak, Anita Płazińska
    Academic press:
    Proteins (rok: 2024, tom: 93, strony: 728-744), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/prot.26766 - link to the publication
  1. Farmakoterapia chorób serca. (Treatment for heart disease.).
    Authors:
    Monika Maciąg, Olga Wronikowska, Łukasz Kurach, Maria Zykubek, Anita Płazińska.
    Book:
    Nauki medyczne i nauki o zdrowiu : Medycyna i farmacja. (rok: 2020, tom: 1, strony: 77-82), Wydawca: Wydawnictwo Młodzi Naukowcy
    Status:
    Published
  2. Wpływ polimorfizmu receptora beta2 adrenergicznego na przebieg i farmakoterapię chorób przewlekłych.
    Authors:
    Aneta Archała, Paweł Kozyra, Anita Płazińska.
    Book:
    Nauki medyczne i nauki o zdrowiu – Część IV (rok: 2020, tom: 4, strony: 45850), Wydawca: Nauka i przemysł - lubelskie spotkania studenckie : praca zbiorowa. Pod red. Doroty Kołodyńskiej, s. 19-21, bibliogr. poz. 23.
    Status:
    Published

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