Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Bacterial toxin-antitoxin systems as novel target for the development of potential antibiotics

2017/25/N/NZ1/01578

Keywords:

antisense oligonucleotides peptide nucleic acid PNA toxin-antitoxin E.coli

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_9: Biotechnology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Równicki 

Number of co-investigators in the project: 3

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 119 700 PLN

Project start date (Y-m-d): 2018-02-20

Project end date (Y-m-d): 2020-03-19

Project duration:: 25 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Antimicrobial synergy between mRNA targeted peptide nucleic acid and antibiotics in E. coli
    Authors:
    Jaime Ivan Castillo, Marcin Równicki, Monika Wojciechowska, Joanna Trylska
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2018, tom: 28, strony: 3094–3098), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2018.07.037 - link to the publication
  2. Antibacterial peptide nucleic acids - facts and perspectives
    Authors:
    Monika Wojciechowska, Marcin Równicki, Adam Mieczkowski, Joanna Miszkiewicz, Joanna Trylska
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 559), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25030559 - link to the publication
  3. Artificial activation of Escherichia coli mazEF and hipBA toxin–antitoxin systems by antisense peptide nucleic acids as an antibacterial strategy
    Authors:
    Marcin Równicki, Tomasz Pieńko, Jakub Czarnecki, Monika Kolanowska, Dariusz Bartosik, Joanna Trylska
    Academic press:
    Frontiers in Microbiology (rok: 2018, tom: 9, strony: 45303), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2018.02870 - link to the publication

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