Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Identification of the mechanism of antineoplastic activity of metformin, as an experimental approach to improve cancer treatment.

2017/25/B/NZ7/02183

Keywords:

metformin PRODH POX proline AMPK apoptosis autophagy

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Pałka 

Number of co-investigators in the project: 7

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 852 060 PLN

Project start date (Y-m-d): 2018-05-07

Project end date (Y-m-d): 2022-05-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Licencja do programu SnapGene (7 000 PLN)
  2. Zestaw do elektroforezy poziomy (18 000 PLN)
  3. Obiektyw do mikroskopu konfokalnego, powiększenie 100x (20 500 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (11)
  1. Metformin treatment or PRODH/POX-knock out similarly induces apoptosis by reprograming of amino acid metabolism, TCA, urea cycle and pentose phosphate pathway in MCF-7 breast cancer cells
    Authors:
    Huynh Thi Yen Ly, Ościłowska Ilona, Saiz Jorge, Nizioł Magdalena, Baszanowska Weronika, Barbas Coral, Pałka Jerzy.
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 21 pp, Article ID 1888), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11121888 - link to the publication
  2. Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy.
    Authors:
    Pałka Jerzy, Ościłowska Ilona, Szoka Łukasz Marek.
    Academic press:
    Amino Acids (rok: 2021, tom: 53, strony: 1917-1925), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-021-02968-y - link to the publication
  3. Proline‑dependent regulation of collagen metabolism
    Authors:
    Karna E, Szoka L, Huynh TYL, Palka J
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2019, tom: -, strony: 8pp), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03363-3 - link to the publication
  4. Metformin induces PRODH/POX-dependent apoptosis in breast cancer cells.
    Authors:
    Huynh Thi Yen Ly, Ościłowska Ilona, Szoka Łukasz, Piktel Ewelina, Baszanowska Weronika, Bielawska Katarzyna, Bucki Robert, Miltyk Wojciech, Pałka Jerzy.
    Academic press:
    Frontiers in Molecular Biosciences (rok: 2022, tom: 9 (11), strony: Article ID 869413), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fmolb.2022.869413 - link to the publication
  5. Overexpression of Prolidase Induces Autophagic Death in MCF-7 Breast Cancer Cells
    Authors:
    Zaręba Ilona, Huynh Thi Yen Ly, Kazberuk Adam, Teul Joanna, Klupczyńska Agnieszka, Matysiak Jan, Surażyński Arkadiusz, Pałka Jerzy.
    Academic press:
    Cellular Physiology and Biochemistry (rok: 2020, tom: 54, strony: 875-887), Wydawca: Cell Physiol Biochem Press
    Status:
    Published
    DOI:
    10.33594/000000275 - link to the publication
  6. Proline dehydrogenase/proline oxidase (PRODH/POX) is involved in the mechanism of metformin-induced apoptosis in C32 melanoma cell line.
    Authors:
    Ościłowska Ilona, Rółkowski Karol, Baszanowska Weronika, Huynh Thi Yen Ly, Lewoniewska Sylwia, Nizioł Magdalena, Sawicka Magdalena, Bielawska Katarzyna, Szoka Paweł, Miltyk Wojciech, Pałka Jerzy.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, 4, 15 pp, strony: Article ID: 2354), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23042354 - link to the publication
  7. Understanding the role of key amino acids in regulation of proline dehydrogenase/proline oxidase (prodh/pox)-dependent apoptosis/autophagy as an approach to targeted cancer therapy.
    Authors:
    Huynh TYL, Zareba I, Baszanowska W, Lewoniewska S, Palka J
    Academic press:
    Molecular and Cellular Biochemistry (rok: 2020, tom: 466, strony: 10pp), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11010-020-03685-y - link to the publication
  8. Development of an LC-MS targeted metabolomics methodology to study proline metabolism in mammalian cell cultures.
    Authors:
    Klupczyńska Agnieszka, Misiura Magdalena, Miltyk Wojciech, Ościłowska Ilona, Pałka Jerzy, Kokot Zenon, Matysiak Jan.
    Academic press:
    Molecules (rok: 2020, tom: 25, strony: 13 pp, Article ID 4639), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules25204639 - link to the publication
  9. Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells.
    Authors:
    Ościłowska Ilona, Huynh Thi Yen Ly, Baszanowska Weronika, Prokop Izabela, Surażyński Arkadiusz, Galli Mauro, Zabielski Piotr, Pałka Jerzy.
    Academic press:
    Amino Acids (rok: 2021, tom: 53, strony: 1943-1956), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-021-03013-8 - link to the publication
  1. Metformin inhibits collagen biosynthesis facilatating proline availability for PRODH/POX-dependent apoptosis/autophagy in MCF-7 breast cancer cells.
    Authors:
    Baszanowska W, Huynh TYL, ZarebaI, Lewoniewska S, Cywoniuk A, Petelska E, Palka J
    Conference:
    XVIII International Congress of Medical Sciences (rok: 2019, ), Wydawca: ASSOCIATION OF MEDICAL STUDENTS IN BULGARIA-SOFIA
    Data:
    konferencja 2019-05-09-12
    Status:
    Published
  2. Metformina indukuje PRODH/POX-zależną apoptozę/autofagię w komórkach raka piersi MCF-7.
    Authors:
    Baszanowska Weronika, Huynh Thi Yen Ly, Lewoniewska Sylwia, Zaręba Ilona, Pałka Jerzy.
    Conference:
    III Poznańska Konferencja "Współczesna analityka farmaceutyczna i biomedyczna w ochronie zdrowia". Poznań, konferencja on-line, 04-05.06.2020. (rok: 2020, ), Wydawca: Wydawnictwo Naukowe Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
    Data:
    konferencja 04-05.06.2020
    Status:
    Published
  3. Multi-omics approach to understand the role of PRODH/POX in regulation of apoptotic pathway in MCF-7 breast cancer cells.
    Authors:
    Huynh Thi Yen Ly, Ościłowska Ilona, Nizioł Magdalena, Saiz Jorge, Barbas Coral, Baszanowska Weronika, Lewoniewska Sylwia, Pałka Jerzy.
    Conference:
    Next-Generation Protein Analysis and Detection (4th edition) (rok: 2022, ), Wydawca: VIB Headquarters
    Data:
    konferencja 30-31.05.2022
    Status:
    Published
  4. Pharmacologic approach to proline oxidase-mediated apoptosis/autophagy as a novel, experimental anti-cancer strategy.
    Authors:
    Zarba I, Celinska-Janowicz K, Kazberuk A, Surazynski A, Miltyk W, Petelska E, Cywoniuk A, Palka J
    Conference:
    IX Konwersatorium Chemii Medycznej (rok: 2018, ), Wydawca: Polskie Towarzystwo Chemii Medycznej
    Data:
    konferencja 2018-09-13-15
    Status:
    Published
  5. Proline dehydrogenase/ Proline Oxidase knockdown inhibits p53dependent apoptosis in MCF-7 breast cancer cells.
    Authors:
    Huynh Thi Yen Ly, Baszanowska Weronika, Lewoniewska Sylwia, Ościłowska Ilona, Pałka Jerzy.
    Conference:
    EMBO Workshop "Systems approaches in cancer" (rok: 2021, ), Wydawca: EMBO
    Data:
    konferencja 21-26.09.2021
    Status:
    Published
  6. Down-regulation of p53 expression in proline dehydrogenase/proline oxidase (PRODH/POX) - dependent pathways in MCF-7 breast cancer cell.
    Authors:
    Huynh TYL, Baszanowska W, Lewoniewska S, Zareba I, Palka J
    Conference:
    2019 International Conference: Korean Society for Molecular and Cellular Biology (KSMCB) (rok: 2019, ), Wydawca: Korean Society for Molecular and Cellular Biology
    Data:
    konferencja 2019-09-30-10-02
    Status:
    Published
  7. Proline dehydrogenase/proline oxidase (PRODH/POX) influences on AMPK-induced apoptosis/autophagy in breast cancer MCF-7 cells
    Authors:
    Lewoniewska S, Baszanowska W, Huynh TYL, Zareba I, Petelska E, Surazynski A, Palka J
    Conference:
    XVIII International Congress of Medical Sciences (rok: 2019, ), Wydawca: ASSOCIATION OF MEDICAL STUDENTS IN BULGARIA-SOFIA
    Data:
    konferencja 2019-05-09-12
    Status:
    Published
  8. The role of proline dehydrogenase/proline oxidase (PRODH/POX) in metformin-induced apoptosis/autophagy in breast cancer MCF-7 cells.
    Authors:
    Zareba I, Surazynski A, Miltyk W, Palka J
    Conference:
    Polish Scientific Networks, Lodz, 21st-23rd June, 2018. (rok: 2018, ), Wydawca: Polska Akademia Nauk
    Data:
    konferencja 2018-06-21-23
    Status:
    Published
  9. The mechanism for proline dehydrogenase/proline oxidase-dependent regulation of apoptosis/autophagy in MCF-7 breast cancer cells.
    Authors:
    Huynh Thi Yen Ly, Baszanowska Weronika, Lewoniewska Sylwia, Zaręba Ilona, Pałka Jerzy.
    Conference:
    III Poznańska Konferencja "Współczesna analityka farmaceutyczna i biomedyczna w ochronie zdrowia". Poznań, konferencja on-line, 04-05.06.2020. (rok: 2020, ), Wydawca: Wydawnictwo Naukowe Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
    Data:
    konferencja 04-05.06.2020
    Status:
    Published
  10. POX-dependent inhibition of P53 expression in MCF-7 creast cancer cell.
    Authors:
    Huynh TYL, Lewoniewska S, Baszanowska W
    Conference:
    XVIII International Congress of Medical Sciences (rok: 2019, ), Wydawca: ASSOCIATION OF MEDICAL STUDENTS IN BULGARIA-SOFIA
    Data:
    konferencja 2019-05-09-12
    Status:
    Published
  11. Metformin induces PRODH/POX expression by AMPK signalling in MCF-7 cells.
    Authors:
    Zareba I, Celinska-Janowicz K, Surazynski A, Miltyk W, Palka J
    Conference:
    Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry MedChemSicily2018 (rok: 2018, ), Wydawca: European Federation for Medicinal Chemistry (EFMC)
    Data:
    konferencja 2018-07-17-20
    Status:
    Published

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