Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Exosome biosensors - new tools in cancer screening, diagnostics and development of targeted drug delivery system

2017/25/B/ST4/01362

Keywords:

exosomes electrochemical biosensors nanogravimetric biosensors drugs antibodies Raman spectroscopy microfluidic system

Descriptors:

  • ST4_11: Coordination and supramolecular chemistry
  • ST4_6: Instrumental methods in chemistry
  • ST4_9: Biological chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Stobiecka 

Number of co-investigators in the project: 4

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 138 480 PLN

Project start date (Y-m-d): 2018-02-21

Project end date (Y-m-d): 2021-08-20

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Ultrawirówka z przyspieszeniem 200 000 x g do izolacji egzosomów z rotorem (215 000 PLN)
  2. stanowisko do Ramana (100 000 PLN)
  3. stanowisko do mikroprzepływów (wytworzone przez zespół) (36 000 PLN)
  4. komputer z dodatkowym oprogramowaniem EndNote (3 200 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Gated Resonance Energy Transfer (gRET) Controlled by Programmed Death Protein Ligand 1
    Authors:
    H. Grel, K. Ratajczak, S. Jakiela* and M. Stobiecka*
    Academic press:
    Nanomaterials (rok: 2020, tom: 10(8), strony: 1592), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano10081592 - link to the publication
  2. Monitoring of dynamic ATP level changes by oligomycin-modulated ATP synthase inhibition in SW480 cancer cells using fluorescent On-Off" switching DNA aptamer
    Authors:
    K. Ratajczak, A. Lukasiak, H. Grel, B. Dworakowska, S. Jakiela*, M. Stobiecka*
    Academic press:
    Anaalytical andl Bioanayticall Chemistry (rok: 2019, tom: 411, strony: 6899–6911), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00216-019-02061-0 - link to the publication
  3. New ISE-Based Apparatus for Na+, K+, Cl-, pH and Transepithelial Potential Difference Real-Time Simultaneous Measurements of Ion Transport across Epithelial Cells Monolayer-Advantages and Pitfalls
    Authors:
    M. Zajac, A. Lewenstam, M. Stobiecka, K. Dołowy
    Academic press:
    Sensors (rok: 2019, tom: 19, strony: 1881), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/s19081881 - link to the publication
  4. High-performance modified cellulose paper-based biosensors for medical diagnostics and early cancer screening: A concise review.
    Authors:
    K. Ratajczak, M. Stobiecka*
    Academic press:
    Carbohydrate Polymers (rok: 2020, tom: 229, strony: 115463), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.carbpol.2019.115463 - link to the publication
  5. Hairpin–Hairpin Molecular Beacon Interactions for Detection of Survivin mRNA in Malignant SW480 Cells
    Authors:
    K. Ratajczak, B.E. Krazinski, A.E. Kowalczyk, B. Dworakowska, S.r Jakiela*, and M. Stobiecka*
    Academic press:
    ACS Appl. Mater. Interfaces (rok: 2018, tom: 10, strony: 17028−17039), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsami.8b02342 - link to the publication
  6. Optical Biosensing System for the Detection of Survivin mRNA in Colorectal Cancer Cells Using a Graphene Oxide Carrier-Bound Oligonucleotide Molecular Beacon
    Authors:
    K. Ratajczak, B.E. Krazinski, A.E. Kowalczyk, B. Dworakowska , S. Jakiela* and M. Stobiecka*
    Academic press:
    Nanomaterials (rok: 2018, tom: 8, strony: 510; 1-12), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/nano8070510 - link to the publication
  7. Toward early cancer detection: Focus on biosensing systems and biosensors for an anti-apoptotic protein survivin and survivin mRNA
    Authors:
    M. Stobiecka*, K. Ratajczak, S. Jakiela*
    Academic press:
    Biosensors and Bioelectronics (rok: 2019, tom: 137, strony: 58-71), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bios.2019.04.060 - link to the publication
  8. Progress in anticancer drug development and targeted delivery for immune response modulation via PD-1/PD-L1 checkpoint control
    Authors:
    K. Ratajczak, H. Grel, S. Jakiela* and M. Stobiecka*
    Academic press:
    International Journal of Molecular Sciences , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication

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