Intracellular cross-talk between ligands and Notch receptors determine signalling response
2017/25/B/NZ4/02364
Keywords
Descriptors
- NZ1_9: Biotechnologia
- NZ5_3: Patogeneza chorób człowieka
- NZ4_2: Fizjologia
Panel
NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution
Uniwersytet Medyczny w Lublinie, Wydział Lekarski
Voivodeship: lubelskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 3
Call
OPUS 13 – announced on 2017-03-15
- Amount awarded
- 1 615 280 PLN
- Project start date
- 2018-02-09
- Project end date
- 2022-12-08
- Project duration
- 58 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (6)
-
Additive pharmacological interaction between cisplatin (CDDP) and histone deacetylase inhibitors (HDIs) in MDA-MB-231 triple negative breast cancer (TNBC) cells with altered Notch1 activity - an isobolographic analysis.
- Authors:
- Anna Wawruszak, Jarogniew J. Luszczki, Joanna Kałafut, Karolina Okła, Marta Hałasa, Adolfo Rivero-Müller, Andrzej Stepulak.
- Academic press:
- International Journal of Molecular Sciences (year: 2019, volume: 20(15), pages: 46039), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms20153663 – link to the publication
-
Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis
- Authors:
- Julia O Misiorek , Alicja Przybyszewska-Podstawka , Joanna Kałafut , Beata Paziewska , Katarzyna Rolle , Adolfo Rivero-Müller, Matthias Nees
- Academic press:
- Cells (year: 2021, volume: 10(1), pages: 94), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells10010094 – link to the publication
-
Shooting at Moving and Hidden Targets-Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas
- Authors:
- Joanna Kałafut , Arkadiusz Czerwonka , Alinda Anameriç , Alicja Przybyszewska-Podstawka , Julia O Misiorek , Adolfo Rivero-Müller, Matthias Nees
- Academic press:
- Cancers (year: 2021, volume: 13(24), pages: 6219), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cancers13246219 – link to the publication
-
Optogenetic control of NOTCH1 signaling
- Authors:
- Kałafut J, Czapiński J, Przybyszewska-Podstawka A, Czerwonka A, Odrzywolski A, Sahlgren C, Rivero-Müller A
- Academic press:
- Cell Communication and Signaling (year: 2022, volume: 20 (1), pages: 67), Publisher: BioMed Central Ltd
- Status:
- Published
- DOI:
- 10.1186/s12964-022-00885-5 – link to the publication
-
Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together
- Authors:
- Anna Wawruszak, Jarogniew Luszczki, Marta Halasa, Estera Okon, Sebastian Landor, Cecilia Sahlgren, Adolfo Rivero-muller, Andrzej Stepulak
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22(10), pages: 5184), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22105184 – link to the publication
-
Optogenetics in cancer drug discovery.
- Authors:
- Kiełbus M, Czapiński J, Odrzywolski A, Stasiak G, Szymańska K, Kałafut J, Kos M, Giannopoulos K, Stepulak A, Rivero-Müller A
- Academic press:
- Expert Opinion on Drug Discovery (year: 2018, volume: 15, pages: 46036), Publisher: Taylor & Francis
- Status:
- Published
- DOI:
- 10.1080/17460441.2018.1437138 – link to the publication