Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Intracellular cross-talk between ligands and Notch receptors determine signalling response

2017/25/B/NZ4/02364

Keywords:

Notch Dll Jagged cell differentiation signalling cell communication angiogenesis tissue homeostasis

Descriptors:

  • NZ1_9:
  • NZ5_3:
  • NZ4_2:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Adolfo Rivero-Muller 

Number of co-investigators in the project: 3

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 615 280 PLN

Project start date (Y-m-d): 2018-02-09

Project end date (Y-m-d): 2022-12-08

Project duration:: 58 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Optogenetics in cancer drug discovery.
    Authors:
    Kiełbus M, Czapiński J, Odrzywolski A, Stasiak G, Szymańska K, Kałafut J, Kos M, Giannopoulos K, Stepulak A, Rivero-Müller A
    Academic press:
    Expert Opinion on Drug Discovery (rok: 2018, tom: 15, strony: 45671), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17460441.2018.1437138 - link to the publication
  2. Shooting at Moving and Hidden Targets-Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas
    Authors:
    Joanna Kałafut , Arkadiusz Czerwonka , Alinda Anameriç , Alicja Przybyszewska-Podstawka , Julia O Misiorek , Adolfo Rivero-Müller, Matthias Nees
    Academic press:
    Cancers (rok: 2021, tom: 13(24), strony: 6219), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13246219 - link to the publication
  3. Optogenetic control of NOTCH1 signaling
    Authors:
    Kałafut J, Czapiński J, Przybyszewska-Podstawka A, Czerwonka A, Odrzywolski A, Sahlgren C, Rivero-Müller A
    Academic press:
    Cell Communication and Signaling (rok: 2022, tom: 20 (1), strony: 67), Wydawca: BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s12964-022-00885-5 - link to the publication
  4. Additive pharmacological interaction between cisplatin (CDDP) and histone deacetylase inhibitors (HDIs) in MDA-MB-231 triple negative breast cancer (TNBC) cells with altered Notch1 activity - an isobolographic analysis.
    Authors:
    Anna Wawruszak, Jarogniew J. Luszczki, Joanna Kałafut, Karolina Okła, Marta Hałasa, Adolfo Rivero-Müller, Andrzej Stepulak.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(15), strony: 45674), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20153663 - link to the publication
  5. Sensitization of MCF7 Cells with High Notch1 Activity by Cisplatin and Histone Deacetylase Inhibitors Applied Together
    Authors:
    Anna Wawruszak, Jarogniew Luszczki, Marta Halasa, Estera Okon, Sebastian Landor, Cecilia Sahlgren, Adolfo Rivero-muller, Andrzej Stepulak
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22(10), strony: 5184), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22105184 - link to the publication
  6. Shooting at Moving and Hidden Targets-Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas
    Authors:
    Joanna Kałafut , Arkadiusz Czerwonka , Alinda Anameriç , Alicja Przybyszewska-Podstawka , Julia O Misiorek , Adolfo Rivero-Müller, Matthias Nees
    Academic press:
    Cancers (rok: 2021, tom: 13(24), strony: 6219), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13246219 - link to the publication
  7. Optogenetic control of NOTCH1 signaling
    Authors:
    Kałafut J, Czapiński J, Przybyszewska-Podstawka A, Czerwonka A, Odrzywolski A, Sahlgren C, Rivero-Müller A
    Academic press:
    Cell Communication and Signaling (rok: 2022, tom: 20 (1), strony: 67), Wydawca: BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s12964-022-00885-5 - link to the publication
  8. Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis
    Authors:
    Julia O Misiorek , Alicja Przybyszewska-Podstawka , Joanna Kałafut , Beata Paziewska , Katarzyna Rolle , Adolfo Rivero-Müller, Matthias Nees
    Academic press:
    Cells (rok: 2021, tom: 10(1), strony: 94), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10010094 - link to the publication
  9. Context Matters: NOTCH Signatures and Pathway in Cancer Progression and Metastasis
    Authors:
    Julia O Misiorek , Alicja Przybyszewska-Podstawka , Joanna Kałafut , Beata Paziewska , Katarzyna Rolle , Adolfo Rivero-Müller, Matthias Nees
    Academic press:
    Cells (rok: 2021, tom: 10(1), strony: 94), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10010094 - link to the publication

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